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A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

1
Faculty of Medicine, University of Ostrava, 703 00 Ostrava, Czech Republic
2
Faculty of Science, University of Ostrava, 701 03 Ostrava, Czech Republic
3
Department of Haematooncology, University Hospital Ostrava, 708 52 Ostrava, Czech Republic
*
Author to whom correspondence should be addressed.
Cancers 2020, 12(5), 1333; https://doi.org/10.3390/cancers12051333
Received: 14 April 2020 / Revised: 17 May 2020 / Accepted: 20 May 2020 / Published: 23 May 2020
(This article belongs to the Special Issue Hematologic Malignancy)
Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source. View Full-Text
Keywords: cell-based therapy; blood cancer; CAR-T cells; NK cells; dendritic cells; platelets; macrophages; iPSC; stem cells cell-based therapy; blood cancer; CAR-T cells; NK cells; dendritic cells; platelets; macrophages; iPSC; stem cells
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Motais, B.; Charvátová, S.; Hrdinka, M.; Šimíček, M.; Jelínek, T.; Ševčíková, T.; Kořístek, Z.; Hájek, R.; Bagó, J.R. A Bird’s-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers. Cancers 2020, 12, 1333.

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