Table of Contents
Cancers, Volume 12, Issue 5 (May 2020) – 290 articles
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Cover Story (view full-size image) RNA editing is a post-transcriptional modification of RNA that leads to specific [...] Read more. RNA editing is a post-transcriptional modification of RNA that leads to specific adenosine-to-inosine (a guanosine analog) or cytosine-to-uracil changes. Adenosine-to-inosine editing is mediated by ADARs (adenosine deaminases that act on RNA), and cytosine-to-uracil editing is catalyzed by apolipoprotein B mRNA editing, catalytic polypeptide-like (APOBEC) enzymes. In this study, we investigated RNA editing using next-generation miRNA sequencing data from chronic lymphocytic leukemia samples and found leukemia-specific editing of some miRNAs. Many of these editing events affect the seeding regions of the respective miRNA, which changes the specificity for particular mRNA targets. Hence, our study shows that in addition to deregulated miRNA expression, aberrant miRNA editing should also be considered in the pathogenesis of cancer. View this paper.