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Micromachines, Volume 9, Issue 4

2018 April - 58 articles

Cover Story: Thermotaxis and chemotaxis are defined as the tendency of cells and microorganisms under thermal and chemical gradients to migrate toward favorable physical situations and avoid damage and death. Advances in microfluidics have enhanced the precision of controlling and capturing microscale samples, and bridged the gap between in-vitro and in-situ assays, specifically in taxis experiments. Thermo- and chemotaxis inspired the design and development of novel microfluidic systems and devices based on thermocapillary and chemocapillary flow control. View this paper
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Articles (58)

  • Perspective
  • Open Access
22 Citations
9,673 Views
19 Pages

20 April 2018

Microfluidic devices are used in a myriad of biomedical applications such as cancer screening, drug testing, and point-of-care diagnostics. Three-dimensional (3D) printing offers a low-cost, rapid prototyping, efficient fabrication method, as compare...

  • Article
  • Open Access
11 Citations
5,838 Views
13 Pages

20 April 2018

A localized maskless modification method of polyurethane (PU) films through an atmospheric pressure He/O2 plasma microjet (APPμJ) was proposed. The APPμJ system combines an atmospheric pressure plasma jet (APPJ) with a microfabricated silicon m...

  • Article
  • Open Access
44 Citations
5,937 Views
15 Pages

Electrostatically Driven In-Plane Silicon Micropump for Modular Configuration

  • Sebastian Uhlig,
  • Matthieu Gaudet,
  • Sergiu Langa,
  • Klaus Schimmanz,
  • Holger Conrad,
  • Bert Kaiser and
  • Harald Schenk

18 April 2018

In this paper, an in-plane reciprocating displacement micropump for liquids and gases which is actuated by a new class of electrostatic bending actuators is reported. The so-called “Nano Electrostatic Drive” is capable of deflecting beyon...

  • Article
  • Open Access
14 Citations
13,049 Views
12 Pages

18 April 2018

Scientific communities are drawn to the open source model as an increasingly utilitarian method to produce and share work. Initially used as a means to develop freely-available software, open source projects have been applied to hardware including sc...

  • Article
  • Open Access
13 Citations
4,540 Views
11 Pages

18 April 2018

Minimized motors can harvest different types of energy and transfer them into kinetic power to carry out complex operations, such as targeted drug delivery, health care, sensing and so on. In recent years, the liquid metal motor is emerging as a very...

  • Article
  • Open Access
1 Citations
5,381 Views
10 Pages

Parametric Excitation of Optomechanical Resonators by Periodical Modulation

  • Jianguo Huang,
  • Muhammad Faeyz Karim,
  • Jiuhui Wu,
  • Tianning Chen and
  • Aiqun Liu

18 April 2018

Optical excitation of mechanical resonators has long been a research interest, since it has great applications in the physical and engineering field. Previous optomechanical methods rely on the wavelength-dependent, optical anti-damping effects, with...

  • Article
  • Open Access
12 Citations
7,160 Views
15 Pages

18 April 2018

Microfluidic quartz crystal microbalances (QCM) can be used as powerful biosensors that not only allow quantifying a target analyte, but also provide kinetic information about the surface processes of binding and release. Nevertheless, their practica...

  • Article
  • Open Access
27 Citations
6,144 Views
18 Pages

17 April 2018

Symmetry enables excellent motion performance of compliant mechanisms, such as minimized parasitic motion, reduced cross-axis coupling, mitigated buckling, and decreased thermal sensitivity. However, most existing symmetric compliant mechanisms are h...

  • Article
  • Open Access
14 Citations
6,877 Views
12 Pages

A Horizontal Magnetic Tweezers and Its Use for Studying Single DNA Molecules

  • Roberto Fabian,
  • Christopher Tyson,
  • Pamela L. Tuma,
  • Ian Pegg and
  • Abhijit Sarkar

17 April 2018

We report the development of a magnetic tweezers that can be used to micromanipulate single DNA molecules by applying picoNewton (pN)-scale forces in the horizontal plane. The resulting force–extension data from our experiments show high-resolu...

  • Article
  • Open Access
7 Citations
6,951 Views
13 Pages

Progress on the Use of Commercial Digital Optical Disc Units for Low-Power Laser Micromachining in Biomedical Applications

  • Aarón Cruz-Ramírez,
  • Raúl Sánchez-Olvera,
  • Diego Zamarrón-Hernández,
  • Mathieu Hautefeuille,
  • Lucia Cabriales,
  • Edgar Jiménez-Díaz,
  • Beatriz Díaz-Bello,
  • Jehú López-Aparicio,
  • Daniel Pérez-Calixto and
  • Genaro Vázquez-Victorio
  • + 1 author

16 April 2018

The development of organ-on-chip and biological scaffolds is currently requiring simpler methods for microstructure biocompatible materials in three dimensions, to fabricate structural and functional elements in biomaterials, or modify the physicoche...

  • Review
  • Open Access
48 Citations
7,412 Views
22 Pages

15 April 2018

Due to their high isolation, low insertion loss, high linearity, and low power consumption, microelectromechanical systems (MEMS) switches have drawn much attention from researchers in recent years. In this paper, we introduce the research status of...

  • Feature Paper
  • Article
  • Open Access
12 Citations
7,155 Views
11 Pages

15 April 2018

The application of subwavelength, textured structures to glass surfaces has been shown to reduce reflectivity and also results in self-cleaning due to super-hydrophobicity. However, current methods of producing such textures are typically either expe...

  • Review
  • Open Access
19 Citations
8,710 Views
19 Pages

14 April 2018

Droplet optofluidics technology aims at manipulating the tiny volume of fluids confined in micro-droplets with light, while exploiting their interaction to create “digital” micro-systems with highly significant scientific and technological interests....

  • Article
  • Open Access
10 Citations
5,322 Views
17 Pages

14 April 2018

A novel topology optimization approach is proposed in this paper for the design of three rotational degree-of-freedom (DOF) spatially compliant mechanisms, combining the Jacobian isomorphic mapping matrix with the solid isotropic material with penali...

  • Article
  • Open Access
4 Citations
4,493 Views
9 Pages

Quantitative Evaluation of Dielectric Breakdown of Silicon Micro- and Nanofluidic Devices for Electrophoretic Transport of a Single DNA Molecule

  • Mamiko Sano,
  • Noritada Kaji,
  • Qiong Wu,
  • Toyohiro Naito,
  • Takao Yasui,
  • Masateru Taniguchi,
  • Tomoji Kawai and
  • Yoshinobu Baba

13 April 2018

In the present study, we quantitatively evaluated dielectric breakdown in silicon-based micro- and nanofluidic devices under practical electrophoretic conditions by changing the thickness of the insulating layer. At higher buffer concentration, a sil...

  • Article
  • Open Access
7 Citations
5,862 Views
13 Pages

Bonding-Based Wafer-Level Vacuum Packaging Using Atomic Hydrogen Pre-Treated Cu Bonding Frames

  • Koki Tanaka,
  • Hideki Hirano,
  • Masafumi Kumano,
  • Joerg Froemel and
  • Shuji Tanaka

13 April 2018

A novel surface activation technology for Cu-Cu bonding-based wafer-level vacuum packaging using hot-wire-generated atomic hydrogen treatment was developed. Vacuum sealing temperature at 300 °C was achieved by atomic hydrogen pre-treatment for Cu...

  • Communication
  • Open Access
4 Citations
4,592 Views
9 Pages

13 April 2018

In contrast to traditional drug administration, targeted drug delivery can prolong, localize, target and have a protected drug interaction with the diseased tissue. Drug delivery carriers, such as polymeric micelles, liposomes, dendrimers, nanotubes,...

  • Feature Paper
  • Article
  • Open Access
5 Citations
4,190 Views
13 Pages

12 April 2018

This research proposes a mass sensor based on mechanical resonance that is free from power supply lines (line-free) and incorporates both microfluidic mechanisms and label-free techniques to improve its sensitivity and reusability. The microfluidic l...

  • Article
  • Open Access
13 Citations
4,751 Views
11 Pages

12 April 2018

An acceleration sensor based on piezoelectric thin films is proposed in this paper, which comprises the elastic element of a silicon cantilever beam and a piezoelectric structure with Li-doped ZnO piezoelectric thin films. The Li-doped ZnO piezoelect...

  • Feature Paper
  • Article
  • Open Access
10 Citations
5,449 Views
24 Pages

On Developing Field-Effect-Tunable Nanofluidic Ion Diodes with Bipolar, Induced-Charge Electrokinetics

  • Ye Tao,
  • Weiyu Liu,
  • Yukun Ren,
  • Yansu Hu,
  • Guang Li,
  • Guoyun Ma and
  • Qisheng Wu

12 April 2018

We introduce herein the induced-charge electrokinetic phenomenon to nanometer fluidic systems; the design of the nanofluidic ion diode for field-effect ionic current control of the nanometer dimension is developed by enhancing internal ion concentrat...

  • Article
  • Open Access
3 Citations
7,138 Views
13 Pages

11 April 2018

Thermocompression bonding for wafer-level hermetic packaging was demonstrated at the lowest temperature of 370 to 390 °C ever reported using Al films with thin Sn capping or insertions as bonding layer. For shrinking the chip size of MEMS (micro elec...

  • Article
  • Open Access
23 Citations
7,754 Views
19 Pages

Microfabricated Vapor Cells with Reflective Sidewalls for Chip Scale Atomic Sensors

  • Runqi Han,
  • Zheng You,
  • Fan Zhang,
  • Hongbo Xue and
  • Yong Ruan

11 April 2018

We investigate the architecture of microfabricated vapor cells with reflective sidewalls for applications in chip scale atomic sensors. The optical configuration in operation is suitable for both one-beam and two-beam (pump & probe) schemes. In t...

  • Article
  • Open Access
3 Citations
4,151 Views
19 Pages

11 April 2018

Micro-electromechanical system (MEMS) suspended inductors have excellent radio-frequency (RF) performance, but poor mechanical properties. To improve their reliability, auxiliary pillars have been used. However, few studies have been carried out on t...

  • Article
  • Open Access
48 Citations
10,624 Views
12 Pages

9 April 2018

The fabrication and testing of spiral microchannels with a trapezoidal cross section for the passive separation of microparticles is reported in this article. In contrast to previously reported fabrication methods, the fabrication of trapezoidal spir...

  • Article
  • Open Access
15 Citations
10,075 Views
9 Pages

9 April 2018

A millimeter-wave substrate integrated waveguide (SIW) has been demonstrated using micromachined tungsten-coated through glass silicon via (TGSV) structures. Two-step deep reactive ion etching (DRIE) of silicon vias and selective tungsten coating ont...

  • Article
  • Open Access
10 Citations
4,324 Views
13 Pages

9 April 2018

Microelectromechanical systems (MEMS) resonators require fast, accurate, and cost-effective testing for mass production. Among the different test methods, frequency domain analysis is one of the easiest and fastest. This paper presents the measuremen...

  • Feature Paper
  • Article
  • Open Access
29 Citations
9,360 Views
14 Pages

Stretchable Tattoo-Like Heater with On-Site Temperature Feedback Control

  • Andrew Stier,
  • Eshan Halekote,
  • Andrew Mark,
  • Shutao Qiao,
  • Shixuan Yang,
  • Kenneth Diller and
  • Nanshu Lu

8 April 2018

Wearable tissue heaters can play many important roles in the medical field. They may be used for heat therapy, perioperative warming and controlled transdermal drug delivery, among other applications. State-of-the-art heaters are too bulky, rigid, or...

  • Feature Paper
  • Article
  • Open Access
12 Citations
5,580 Views
9 Pages

Effect of Substrate Support on Dynamic Graphene/Metal Electrical Contacts

  • Jihyung Lee,
  • Xiaoli Hu,
  • Andrey A. Voevodin,
  • Ashlie Martini and
  • Diana Berman

7 April 2018

Recent advances in graphene and other two-dimensional (2D) material synthesis and characterization have led to their use in emerging technologies, including flexible electronics. However, a major challenge is electrical contact stability, especially...

  • Article
  • Open Access
4 Citations
5,073 Views
21 Pages

5 April 2018

We report a new analytical model of the MEMS-based thermal property sensor for samples which are difficult to handle and susceptible to damage by thermal stimulus, such as living cells. Many sensor designs had been reported for thermal property measu...

  • Correction
  • Open Access
2,997 Views
1 Page

2 April 2018

The authors would like to make the following changes to the published paper [1]: Equation (5) should be written as follows:[...]

  • Review
  • Open Access
5 Citations
5,376 Views
20 Pages

2 April 2018

Light manipulation has always been the fundamental subject in the field of optics since centuries ago. Traditional optical devices are usually designed using glasses and other materials, such as semiconductors and metals. Optofluidics is the combinat...

  • Article
  • Open Access
20 Citations
9,863 Views
14 Pages

PDMS-PDMS Micro Channels Filled with Phase-Change Material for Chip Cooling

  • Zong Liu,
  • Siyin Qin,
  • Xingwei Chen,
  • Dazhu Chen and
  • Fei Wang

2 April 2018

This paper reports on a chip cooling solution using polydimethylsiloxane (PDMS) based microfluidic devices filled with n-Octadecane. A thick SU-8 layer of 150 µm is used as the master mold for patterning PDMS fabrication. With the SU-8 mold, patterns...

  • Article
  • Open Access
6 Citations
4,770 Views
12 Pages

2 April 2018

The focus of this study is on the manufacturing of micro air bearings (MABs) using silica film assisted processing. Structure of the three-layer micro air bearing is described in detail and the salient process flow of etching and bonding is illustrat...

  • Article
  • Open Access
7 Citations
4,950 Views
8 Pages

2 April 2018

The ion depletion zone of ion concentration polarization has a strong potential to act as an immaterial barrier, separating delicate submicron substances, including biomolecules, without causing physical damage. However, the detailed mechanisms of th...

  • Article
  • Open Access
19 Citations
13,080 Views
10 Pages

SF6 Optimized O2 Plasma Etching of Parylene C

  • Lingqian Zhang,
  • Yaoping Liu,
  • Zhihong Li and
  • Wei Wang

2 April 2018

Parylene C is a widely used polymer material in microfabrication because of its excellent properties such as chemical inertness, biocompatibility and flexibility. It has been commonly adopted as a structural material for a variety of microfluidics an...

  • Article
  • Open Access
10 Citations
5,630 Views
13 Pages

A Microfluidic Chip with Double-Slit Arrays for Enhanced Capture of Single Cells

  • Jingyi Xu,
  • Shulei Chen,
  • Dongyang Wang,
  • Yue Jiang,
  • Ming Hao,
  • Guangyu Du,
  • Dechun Ba,
  • Qiao Lin,
  • Qi Mei and
  • Kun Liu
  • + 2 authors

1 April 2018

The application of microfluidic technology to manipulate cells or biological particles is becoming one of the rapidly growing areas, and various microarray trapping devices have recently been designed for high throughput single-cell analysis and mani...

  • Review
  • Open Access
21 Citations
7,675 Views
14 Pages

1 April 2018

Water quality-related incidents are attracting attention globally as they cause serious diseases and even threaten human lives. The current detection and monitoring methods are inadequate because of their long operation time, high cost, and complex p...

  • Review
  • Open Access
34 Citations
5,477 Views
7 Pages

Optofluid-Based Reflective Displays

  • Mingliang Jin,
  • Shitao Shen,
  • Zichuan Yi,
  • Guofu Zhou and
  • Lingling Shui

1 April 2018

Displays can present information like text, images, or videos in a different color (visible light) by activating the materials in pixels. In a display device, pixels are typically of micrometer size and filled with displaying materials that are align...

  • Review
  • Open Access
57 Citations
9,340 Views
16 Pages

Passive Mixing inside Microdroplets

  • Chengmin Chen,
  • Yingjie Zhao,
  • Jianmei Wang,
  • Pingan Zhu,
  • Ye Tian,
  • Min Xu,
  • Liqiu Wang and
  • Xiaowen Huang

1 April 2018

Droplet-based micromixers are essential units in many microfluidic devices for widespread applications, such as diagnostics and synthesis. The mixers can be either passive or active. When compared to active methods, the passive mixer is widely used b...

  • Article
  • Open Access
7 Citations
4,178 Views
11 Pages

Electric Power Self-Supply Module for WSN Sensor Node Based on MEMS Vibration Energy Harvester

  • Wenyang Zhang,
  • Ying Dong,
  • Yushan Tan,
  • Min Zhang,
  • Xiang Qian and
  • Xiaohao Wang

1 April 2018

This paper proposes an electric power self-supply module for the wireless sensor network (WSN) sensor node. The module includes an electromagnetic vibration energy harvester based on micro-electro-mechanical system (MEMS) technology and a processing...

  • Feature Paper
  • Article
  • Open Access
7 Citations
7,535 Views
12 Pages

An FEP Microfluidic Reactor for Photochemical Reactions

  • Tomasz Szymborski,
  • Paweł Jankowski,
  • Dominika Ogończyk and
  • Piotr Garstecki

30 March 2018

Organic syntheses based on photochemical reactions play an important role in the medical, pharmaceutical, and polymeric chemistry. For years, photochemistry was performed using high-pressure mercury lamps and immersion-wells. However, due to excellen...

  • Article
  • Open Access
9 Citations
5,020 Views
11 Pages

29 March 2018

Wideband and low-loss microwave power measurements are becoming increasingly important for microwave communication and radar systems. To achieve such a power measurement, this paper presents the design and measurement of wideband DC-25 GHz and low-lo...

  • Article
  • Open Access
28 Citations
5,506 Views
11 Pages

Electroosmotic Flow of Viscoelastic Fluid in a Nanoslit

  • Lanju Mei,
  • Hongna Zhang,
  • Hongxia Meng and
  • Shizhi Qian

29 March 2018

The electroosmotic flow (EOF) of viscoelastic fluid in a long nanoslit is numerically studied to investigate the rheological property effect of Linear Phan-Thien-Tanner (LPTT) fluid on the fully developed EOF. The non-linear Poisson-Nernst-Planck equ...

  • Article
  • Open Access
21 Citations
5,541 Views
14 Pages

Capillary Rise of Nanostructured Microwicks

  • Chang-Ho Choi,
  • Shankar Krishnan,
  • Ward TeGrotenhuis and
  • Chih-Hung Chang

28 March 2018

Capillarity refers to the driving force to propel liquid through small gaps in the absence of external forces, and hence enhanced capillary force has been pursued for various applications. In this study, flower like ZnO nanostructures are successfull...

  • Article
  • Open Access
38 Citations
6,985 Views
11 Pages

Paper-Based Sensor Chip for Heavy Metal Ion Detection by SWSV

  • Xiaoqing Wang,
  • Jizhou Sun,
  • Jianhua Tong,
  • Xin Guan,
  • Chao Bian and
  • Shanhong Xia

27 March 2018

Heavy metal ion pollution problems have had a terrible influence on human health and the environment. Therefore, the monitoring of heavy metal ions is of great practical significance. In this paper, an electrochemical three-electrode system was fabri...

  • Review
  • Open Access
85 Citations
11,523 Views
18 Pages

Deformation of Red Blood Cells, Air Bubbles, and Droplets in Microfluidic Devices: Flow Visualizations and Measurements

  • David Bento,
  • Raquel O. Rodrigues,
  • Vera Faustino,
  • Diana Pinho,
  • Carla S. Fernandes,
  • Ana I. Pereira,
  • Valdemar Garcia,
  • João M. Miranda and
  • Rui Lima

27 March 2018

Techniques, such as micropipette aspiration and optical tweezers, are widely used to measure cell mechanical properties, but are generally labor-intensive and time-consuming, typically involving a difficult process of manipulation. In the past two de...

  • Article
  • Open Access
6 Citations
5,723 Views
12 Pages

A Control and Detecting System of Micro-Near-Infrared Spectrometer Based on a MOEMS Scanning Grating Mirror

  • Haitao Liu,
  • Zhiyu Wen,
  • Dongling Li,
  • Jian Huang,
  • Ying Zhou and
  • Pengfei Guo

27 March 2018

Based on the scanning grating mirror we developed, this paper presents a method of the precise control of a scanning grating mirror and of high-speed spectrum data detection. In addition, the system circuit of the scanning grating mirror control and...

  • Review
  • Open Access
22 Citations
10,721 Views
28 Pages

26 March 2018

Taxis has been reported in many cells and microorganisms, due to their tendency to migrate toward favorable physical situations and avoid damage and death. Thermotaxis and chemotaxis are two of the major types of taxis that naturally occur on a daily...

  • Article
  • Open Access
17 Citations
6,388 Views
13 Pages

25 March 2018

RSA 905, a rapidly solidified aluminum alloy, has been widely utilized in optical, automotive, and aerospace industries owing to its superior mechanical properties such as hardness and strength compared to conventional aluminum alloys. However, the s...

  • Article
  • Open Access
11 Citations
4,877 Views
10 Pages

25 March 2018

A diamond-like carbon (DLC) film, coated on an SKD11 (alloy tool steel) substrate, was shaped by plasma oxidation to form an assembly of DLC macro-pillars and to be used as a DLC-punch array that is micro-embossed into aluminum sheets. First, the SKD...

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Micromachines - ISSN 2072-666X