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Micromachines 2018, 9(4), 182; https://doi.org/10.3390/mi9040182

Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications

Institute of Biomedical & Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
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Received: 23 January 2018 / Revised: 3 April 2018 / Accepted: 5 April 2018 / Published: 13 April 2018
(This article belongs to the Special Issue Locomotion at Small Scales: From Biology to Artificial Systems)
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Abstract

In contrast to traditional drug administration, targeted drug delivery can prolong, localize, target and have a protected drug interaction with the diseased tissue. Drug delivery carriers, such as polymeric micelles, liposomes, dendrimers, nanotubes, and so on, are hard to scale-up, costly, and have short shelf life. Here we show the novel fabrication and characterization of photopatternable magnetic hollow microrobots that can potentially be utilized in microfluidics and drug delivery applications. These magnetic hollowbots can be fabricated using standard ultraviolet (UV) lithography with low cost and easily accessible equipment, which results in them being easy to scale up, and inexpensive to fabricate. Contact-free actuation of freestanding magnetic hollowbots were demonstrated by using an applied 900 G external magnetic field to achieve the movement control in an aqueous environment. According to the movement clip, the average speed of the magnetic hollowbots was estimated to be 1.9 mm/s. View Full-Text
Keywords: microfabrication; photopatternable; magnetic composite; hollowbots; drug delivery microfabrication; photopatternable; magnetic composite; hollowbots; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Li, H.; Chen, J.; Zhang, J.; Zhang, J.; Zhao, G.; Wang, L. Photopatternable Magnetic Hollowbots by Nd-Fe-B Nanocomposite for Potential Targeted Drug Delivery Applications. Micromachines 2018, 9, 182.

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