Advanced Fabrication Techniques of Microengineered Physiological Systems
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George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
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Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
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Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
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Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA 30332, USA
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Author to whom correspondence should be addressed.
Micromachines 2020, 11(8), 730; https://doi.org/10.3390/mi11080730
Received: 26 June 2020
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Revised: 21 July 2020
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Accepted: 24 July 2020
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Published: 28 July 2020
(This article belongs to the Special Issue Microengineered Physiological Systems for Disease Modeling and Drug Testing)
The field of organs-on-chips (OOCs) has experienced tremendous growth over the last decade. However, the current main limiting factor for further growth lies in the fabrication techniques utilized to reproducibly create multiscale and multifunctional devices. Conventional methods of photolithography and etching remain less useful to complex geometric conditions with high precision needed to manufacture the devices, while laser-induced methods have become an alternative for higher precision engineering yet remain costly. Meanwhile, soft lithography has become the foundation upon which OOCs are fabricated and newer methods including 3D printing and injection molding show great promise to innovate the way OOCs are fabricated. This review is focused on the advantages and disadvantages associated with the commonly used fabrication techniques applied to these microengineered physiological systems (MPS) and the obstacles that remain in the way of further innovation in the field.
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Keywords:
organs-on-chips (OOCs); microengineered physiological system (MPS); body-on-chips (BOCs); fabrication; microfluidic
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MDPI and ACS Style
Puryear III, J.R.; Yoon, J.-K.; Kim, Y. Advanced Fabrication Techniques of Microengineered Physiological Systems. Micromachines 2020, 11, 730. https://doi.org/10.3390/mi11080730
AMA Style
Puryear III JR, Yoon J-K, Kim Y. Advanced Fabrication Techniques of Microengineered Physiological Systems. Micromachines. 2020; 11(8):730. https://doi.org/10.3390/mi11080730
Chicago/Turabian StylePuryear III, Joseph R., Jeong-Kee Yoon, and YongTae Kim. 2020. "Advanced Fabrication Techniques of Microengineered Physiological Systems" Micromachines 11, no. 8: 730. https://doi.org/10.3390/mi11080730
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