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Toxins, Volume 14, Issue 11

November 2022 - 91 articles

Cover Story: Approximately 80% of individuals who suffer spinal cord injury (SCI) will develop hypertrophic and neurogenic bladders resulting in complications including urinary incontinence, urinary tract infection and renal failure. In this study, the authors examined the effect of early bladder chemodenervation with botulinum toxin A on bladder histopathology and collagen deposition. They found that the bladders of SCI rats injected with botulinum toxin A had a significant reduction in detrusor hypertrophy and less fibrous collagen deposition compared to bladders from SCI animals injected with saline. These findings suggest that acute detrusor chemodenervation using botulinum toxin A after SCI can preserve bladder tissue integrity by reducing the development of detrusor fibrosis and hypertrophy associated with SCI. View this paper
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Articles (91)

  • Article
  • Open Access
14 Citations
2,649 Views
17 Pages

14 November 2022

This study aims to examine the impact of zearalenone (ZEA) on glucose nutrient absorption and the role of the Kelch-like erythroid cell-derived protein with CNC homology-associated protein 1 (Keap1)–nuclear factor erythroid 2-related factor 2 (Nrf2)...

  • Communication
  • Open Access
1 Citations
3,906 Views
7 Pages

IncobotulinumtoxinA Injection for Treating Children with Idiopathic Toe Walking: A Retrospective Efficacy and Safety Study

  • Mirko Filippetti,
  • Alessandro Picelli,
  • Rita Di Censo,
  • Sabrina Vantin,
  • Pietro Nicola Randazzo,
  • Giorgio Sandrini,
  • Cristina Tassorelli,
  • Roberto De Icco,
  • Nicola Smania and
  • Stefano Tamburin

13 November 2022

There is no gold-standard treatment for idiopathic toe walking (ITW). Some previous evidence suggested that botulinum neurotoxin-A injection might improve ITW. This is a single-center retrospective study on children with ITW treated with incobotulinu...

  • Article
  • Open Access
15 Citations
3,983 Views
11 Pages

Occurrence and Determination of Alternaria Mycotoxins Alternariol, Alternariol Monomethyl Ether, and Tentoxin in Wheat Grains by QuEChERS Method

  • Nikola Puvača,
  • Giuseppina Avantaggiato,
  • Jordan Merkuri,
  • Gorica Vuković,
  • Vojislava Bursić and
  • Magdalena Cara

12 November 2022

The Alternaria mycotoxins such as alternariol (AOH), alternariol monomethyl ether (AME), and tentoxin (TEN) are mycotoxins, which can contaminate cereal-based raw materials. Today, wheat is one of the most important crops in temperate zones, and it i...

  • Article
  • Open Access
4 Citations
6,024 Views
14 Pages

11 November 2022

Prevailing drug resistance in malaria imposes the major roadblock for the existing interventions necessitating the timely need to search for alternative therapies. Ants in Solenopsis spp, termed ’Fire ants’, are well known for their aggre...

  • Article
  • Open Access
8 Citations
2,471 Views
18 Pages

11 November 2022

This study was undertaken to analyze whether prolonged exposure to low-dose zearalenone (ZEN) mycotoxicosis affects the concentrations of ZEN, α-zearalenol (α-ZEL), and β-zearalenol (β-ZEL) in selected reproductive system tissue...

  • Article
  • Open Access
13 Citations
3,094 Views
13 Pages

11 November 2022

Aspergillus flavus and the produced aflatoxins cause great hazards to food security and human health across all countries. The control of A. flavus and aflatoxins in grains during storage is of great significance to humans. In the current study, bact...

  • Article
  • Open Access
5 Citations
2,875 Views
20 Pages

In Silico Study of the Mechanisms Underlying the Action of the Snake Natriuretic-Like Peptide Lebetin 2 during Cardiac Ischemia

  • Hinda Allaoui,
  • Nedra Rached,
  • Naziha Marrakchi,
  • Ameur Cherif,
  • Amor Mosbah and
  • Erij Messadi

11 November 2022

Lebetin 2 (L2), a natriuretic-like peptide (NP), exerts potent cardioprotection in myocardial infarction (MI), with stronger effects than B-type natriuretic peptide (BNP). To determine the molecular mechanisms underlying its cardioprotection effect,...

  • Article
  • Open Access
10 Citations
3,342 Views
16 Pages

Modelling the Spatial and Temporal Dynamics of Paralytic Shellfish Toxins (PST) at Different Scales: Implications for Research and Management

  • Patricio A. Díaz,
  • Carlos Molinet,
  • Miriam Seguel,
  • Edwin J. Niklitschek,
  • Manuel Díaz,
  • Gonzalo Álvarez,
  • Iván Pérez-Santos,
  • Daniel Varela,
  • Leonardo Guzmán and
  • Camilo Rodríguez-Villegas
  • + 1 author

11 November 2022

Harmful algal blooms, in particular recurrent blooms of the dinoflagellate Alexandrium catenella, associated with paralytic shellfish poisoning (PSP), frequently limit commercial shellfish harvests, resulting in serious socio-economic consequences. A...

  • Article
  • Open Access
5 Citations
3,188 Views
13 Pages

Target Mechanisms of the Cyanotoxin Cylindrospermopsin in Immortalized Human Airway Epithelial Cells

  • Sabine Ziesemer,
  • Susann Meyer,
  • Julia Edelmann,
  • Janita Vennmann,
  • Celine Gudra,
  • Denise Arndt,
  • Marcus Effenberg,
  • Olla Hayas,
  • Aref Hayas and
  • Johanna Sophia Thomassen
  • + 3 authors

11 November 2022

Cylindrospermopsin (CYN) is a cyanobacterial toxin that occurs in aquatic environments worldwide. It is known for its delayed effects in animals and humans such as inhibition of protein synthesis or genotoxicity. The molecular targets and the cell ph...

  • Review
  • Open Access
56 Citations
9,872 Views
21 Pages

Varespladib in the Treatment of Snakebite Envenoming: Development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes

  • Matthew R. Lewin,
  • Rebecca W. Carter,
  • Isabel A. Matteo,
  • Stephen P. Samuel,
  • Sunita Rao,
  • Bryan G. Fry and
  • Philip E. Bickler

11 November 2022

The availability of effective, reliably accessible, and affordable treatments for snakebite envenoming is a critical and long unmet medical need. Recently, small, synthetic toxin-specific inhibitors with oral bioavailability used in conjunction with...

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Toxins - ISSN 2072-6651