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The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update

Department of Pediatrics, Marche Polytechnic University, 60121 Ancona, Italy
Department of Medicine, Columbia University Medical Center, New York, NY 10027, USA
Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Charité, Campus Benjamin Franklin, 12203 Berlin, Germany
Department of Gastroenterology and Liver Diseases, CHU, 38043 Grenoble, France
Celiac Center Amsterdam, Department of Gastroenterology, VU University Medical Center, 1117 Amsterdam, The Netherlands
Department of Internal Medicine, “Giovanni Paolo II” Hospital, Sciacca (AG) and University of Palermo, 92019 Sciacca, Italy
Paediatric Gastroenterology Unit, Sant Joan de Reus University Hospital. IISPV, 43003 Tarragona, Spain
Department of Internal and Experimental Medicine Magrassi-Lanzara, University of Campania Luigi Vanvitelli, 80131 Naples, Italy
Medical Clinic 1, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany
Central Laboratory of Advanced Diagnosis and Biomedical Research (CLADIBIOR), University of Palermo, 90133 Palermo, Italy
Center for the Prevention and Diagnosis of Celiac Disease, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
Center for Celiac Research and Treatment, Massachusetts General Hospital, Boston, MA 02114, USA
Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK
Academic Unit of Gastroenterology, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield S10 2TN, UK
Gastroenterology Unit, Milton Keynes University Hospital, Milton Keynes MK6 5LD, UK
German Research Centre for Food Chemistry, Leibniz Institute, Lise-Meitner-Straße 34, D-85354 Freising, Germany
Institute of Translational Immunology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany
Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy
Author to whom correspondence should be addressed.
Nutrients 2017, 9(11), 1268;
Received: 12 October 2017 / Revised: 14 November 2017 / Accepted: 17 November 2017 / Published: 21 November 2017
PDF [2337 KB, uploaded 24 November 2017]


Gluten-related disorders have recently been reclassified with an emerging scientific literature supporting the concept of non-celiac gluten sensitivity (NCGS). New research has specifically addressed prevalence, immune mechanisms, the recognition of non-immunoglobulin E (non-IgE) wheat allergy and overlap of NCGS with irritable bowel syndrome (IBS)-type symptoms. This review article will provide clinicians with an update that directly impacts on the management of a subgroup of their IBS patients whose symptoms are triggered by wheat ingestion. View Full-Text
Keywords: gluten sensitivity; celiac disease; wheat allergy; gluten-related disorders; gluten-free diet; amylase-trypsin inhibitors (ATIs) gluten sensitivity; celiac disease; wheat allergy; gluten-related disorders; gluten-free diet; amylase-trypsin inhibitors (ATIs)

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Catassi, C.; Alaedini, A.; Bojarski, C.; Bonaz, B.; Bouma, G.; Carroccio, A.; Castillejo, G.; De Magistris, L.; Dieterich, W.; Di Liberto, D.; Elli, L.; Fasano, A.; Hadjivassiliou, M.; Kurien, M.; Lionetti, E.; Mulder, C.J.; Rostami, K.; Sapone, A.; Scherf, K.; Schuppan, D.; Trott, N.; Volta, U.; Zevallos, V.; Zopf, Y.; Sanders, D.S. The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update. Nutrients 2017, 9, 1268.

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