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Nutrients 2016, 8(5), 310;

The Possible Role of Flavonoids in the Prevention of Diabetic Complications

Experimental Models in Clinical Pathology, INRCA-IRCCS National Institute, Ancona I-60127, Italy
Scientific Direction, INRCA-IRCCS National Institute, Ancona I-60127, Italy
Department of Cardiovascular and Metabolic Diseases, IRCCS Multimedica, Sesto San Giovanni I-20099, Italy
Insititut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), C/Rosselló, 149-153, 08036 Barcelona, Spain
Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona 08036, Spain
Author to whom correspondence should be addressed.
Received: 15 March 2016 / Revised: 11 May 2016 / Accepted: 16 May 2016 / Published: 20 May 2016
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Type 2 diabetes mellitus is a disease that affects many metabolic pathways. It is associated with insulin resistance, impaired insulin signaling, β-cell dysfunction, abnormal glucose levels, altered lipid metabolism, sub-clinical inflammation and increased oxidative stress. These and other unknown mechanisms lead to micro- and macro-complications, such as neuropathy, retinopathy, nephropathy and cardiovascular disease. Based on several in vitro animal models and some human studies, flavonoids appear to play a role in many of the metabolic processes involved in type 2 diabetes mellitus. In this review, we seek to highlight the most recent papers focusing on the relationship between flavonoids and main diabetic complications. View Full-Text
Keywords: type 2 diabetes mellitus; diabetic complications; flavonoids type 2 diabetes mellitus; diabetic complications; flavonoids

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Testa, R.; Bonfigli, A.R.; Genovese, S.; De Nigris, V.; Ceriello, A. The Possible Role of Flavonoids in the Prevention of Diabetic Complications. Nutrients 2016, 8, 310.

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