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Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver

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Department of Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, Brazil
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Department of Cell Biology, Biological Sciences Institute, Campus Universitário Darcy Ribeiro, Universidade de Brasília, 70.910-900 Brasília, DF, Brazil
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Author to whom correspondence should be addressed.
Nutrients 2016, 8(2), 38; https://doi.org/10.3390/nu8020038
Received: 25 November 2015 / Revised: 26 November 2015 / Accepted: 14 December 2015 / Published: 17 February 2016
This study investigated the effect of tucum-do-cerrado consumption in the oxidative status of iron-supplemented rats. Four groups of rats were treated: Control (AIN-93G), Tuc (AIN-93G added of tucum-do-cerrado), Fe (AIN-93G iron-enriched), or TucFe (AIN-93G with tucum-do-cerrado and iron-enriched) diet, for 30 days. Iron-enriched diet increased serum, liver, spleen, and intestine iron levels; transferrin saturation; liver lipid oxidation; mRNA levels of hepatic Hamp and Bmp6, and Nrf2 in the intestine. Tucum-do-cerrado consumption reduced spleen lipid and protein oxidation; mRNA levels of hepatic Hamp and Ftl, and increased serum antioxidant capacity and hepatic mRNA levels of Bmp6, Hmox1, Nqo1, and Nrf2. TucFe diet consumption abrogated the liver Hamp iron-induced up-regulation, prevented intestinal iron accumulation; hepatic lipid peroxidation; splenic protein damage, and the increase of catalase, glutathione reductase, and glutathione peroxidase activity in some tissues. These results suggest that tucum-do-cerrado protects tissues against oxidative damage, by reducing iron availability in liver and consequently inhibiting liver Hamp expression. View Full-Text
Keywords: oxidative stress; tucum-do-cerrado (Bactris setosa Mart.); Hamp; Nfr2 oxidative stress; tucum-do-cerrado (Bactris setosa Mart.); Hamp; Nfr2
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Fustinoni-Reis, A.M.; Arruda, S.F.; Dourado, L.P.S.; Da Cunha, M.S.B.; Siqueira, E.M.A. Tucum-Do-Cerrado (Bactris setosa Mart.) Consumption Modulates Iron Homeostasis and Prevents Iron-Induced Oxidative Stress in the Rat Liver. Nutrients 2016, 8, 38.

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