Next Article in Journal
Clinical Assessment of Altered Eating Behaviors in People with Obesity Using the EBA-O Questionnaire
Next Article in Special Issue
Auricularia heimuer Ameliorates Oxidative Stress and Inflammation to Inhibit Atherosclerosis Development in ApoE−/− Mice
Previous Article in Journal
Nutrients and Natural Substances for Hypoglycemic Effects and Management in Diabetic Retinopathy
Previous Article in Special Issue
Tremella fuciformis Berk Alleviated Atherosclerosis Symptoms via Nuclear Factor-Kappa B-Mediated Inflammatory Response in ApoE−/− Mice
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 17
Issue 7
10.3390/nu17071208
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Beneficial Effects of Enoki Mushroom Extract on Male Menopausal Symptoms in Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Study

by
Shizuo Yamada
1,*,
Michiyo Shirai
1,
Koji Nagashima
2,
Jun Mochizuki
2,
Ken Ono
3 and
Shinji Kageyama
4
1
Center for Pharma-Food Research, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
2
TechnoSuruga Laboratory Co., Ltd., Shizuoka 424-0065, Japan
3
Izu Health & Medical Center, Shizuoka 410-0638, Japan
4
Kageyama Urology Clinic, Shizuoka 420-0838, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2025, 17(7), 1208; https://doi.org/10.3390/nu17071208
Submission received: 24 February 2025 / Revised: 24 March 2025 / Accepted: 25 March 2025 / Published: 30 March 2025
(This article belongs to the Special Issue Functional Evaluation of Edible Mushrooms and Their Active Materials)
Browse Figure
Review Reports Versions Notes

Abstract

With the increase in average life expectancy, age-related male menopause has become a cause of decreased quality of life in men. The present study investigated the efficacy and safety of powdered enoki mushroom extract containing adenosine (test food) for menopausal symptoms in middle-aged and elderly men based on an evaluation of Heinemann’s Aging Males’ Symptoms (AMS) scores. The test food and placebo were administered to healthy men with AMS scores of 27–49 for 12 weeks. AMS score (primary endpoint) and testosterone level (secondary endpoint) were evaluated before and 12 weeks after the intake of the test food and placebo. The intake of the test food for 12 weeks significantly improved the sexual subscale of the AMS. In the cumulative χ2 test, the number of subjects showing high improvement was significantly higher in the test food group than in the placebo food group. In a stratified analysis of subjects divided into two groups based on a change in total testosterone levels of <0.5 ng/mL and ≥0.5 ng/mL after the intake of the test food, the number of subjects with increased total testosterone levels of ≥0.5 ng/mL was significantly higher in the test food group than in the placebo group. These results suggest the beneficial effects of enoki mushroom extract on symptoms of male menopause.
Keywords: enoki mushroom; menopause; AMS; testosterone enoki mushroom; menopause; AMS; testosterone

Share and Cite

MDPI and ACS Style

Yamada, S.; Shirai, M.; Nagashima, K.; Mochizuki, J.; Ono, K.; Kageyama, S. Beneficial Effects of Enoki Mushroom Extract on Male Menopausal Symptoms in Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients 2025, 17, 1208. https://doi.org/10.3390/nu17071208

AMA Style

Yamada S, Shirai M, Nagashima K, Mochizuki J, Ono K, Kageyama S. Beneficial Effects of Enoki Mushroom Extract on Male Menopausal Symptoms in Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2025; 17(7):1208. https://doi.org/10.3390/nu17071208

Chicago/Turabian Style

Yamada, Shizuo, Michiyo Shirai, Koji Nagashima, Jun Mochizuki, Ken Ono, and Shinji Kageyama. 2025. "Beneficial Effects of Enoki Mushroom Extract on Male Menopausal Symptoms in Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Study" Nutrients 17, no. 7: 1208. https://doi.org/10.3390/nu17071208

APA Style

Yamada, S., Shirai, M., Nagashima, K., Mochizuki, J., Ono, K., & Kageyama, S. (2025). Beneficial Effects of Enoki Mushroom Extract on Male Menopausal Symptoms in Japanese Subjects: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients, 17(7), 1208. https://doi.org/10.3390/nu17071208

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop