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Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study

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Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario de Málaga—Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain
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Departmento de Medicina y Dermatología, Universidad de Málaga, 29071 Málaga, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitari de Bellvitge, 08907 L’Hospitalet de Llobregat (Barcelona), Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario de Guadalajara, 19002 Guadalajara, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain
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Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain
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Sección de Endocrinología y Nutrición, Hospital Universitario de Fuenlabrada, 28942 Madrid, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario de Badajoz, 06080 Badajoz, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario Príncipe de Asturias, 28805 Madrid, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario Lozano Blesa, 50009 Zaragoza, Spain
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Servicio de Endocrinología y Nutrición, Hospital General La Mancha Centro, 13600 Alcázar de San Juan, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario Gregorio Marañón, 28007 Madrid, Spain
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Unidad de Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain
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Servicio de Endocrinología y Nutrición, Hospital Clínico San Carlos, 28040 Madrid, Spain
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Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario de Valladolid, 47005 Valladolid, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario Son Llatzer, 07198 Illes Balears, Spain
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Servicio de Endocrinología y Nutrición, Complejo Hospitalario de Jaén, 23007 Jaén, Spain
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Servicio de Endocrinología y Nutrición, Complejo Hospitalario Universitario de Ferrol, 15045 A Coruña, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario Severo Ochoa, 28914 Leganés (Madrid), Spain
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Servicio de Endocrinología y Nutrición, Complejo Asistencial Universitario de León, 24071 León, Spain
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Unidad de Nutrición – Sección de Endocrinología, Hospital General Universitario de Alicante, 03010 Alicante, Spain
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Servicio de Endocrinología y Nutrición, Hospital Universitario Reina Sofía, 14004 Córdoba, Spain
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Servicio de Endocrinología y Nutrición, Complejo Hospitalario de Navarra, 31008 Navarra, Spain
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Servicio de Endocrinología y Nutrición, Hospital de Mérida, 06800 Badajoz, Spain
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Servicio de Endocrinología y Nutrición, Hospital de Sant Joan Despí Moisès Broggi, 08970 Barcelona, Spain
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CIBERDEM (CB07/08/0019), Instituto de Salud Carlos III, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(6), 1566; https://doi.org/10.3390/nu12061566
Received: 9 May 2020 / Revised: 20 May 2020 / Accepted: 25 May 2020 / Published: 27 May 2020
(This article belongs to the Section Clinical Nutrition)
There are no studies that have specifically assessed the role of intravenous lipid emulsions (ILE) enriched with fish oil in people with diabetes receiving total parenteral nutrition (TPN). The objective of this study was to assess the metabolic control (glycemic and lipid) and in-hospital complications that occurred in non-critically ill inpatients with TPN and type 2 diabetes with regard to the use of fish oil emulsions compared with other ILEs. We performed a post-hoc analysis of the Insulin in Parenteral Nutrition (INSUPAR) trial that included patients who started with TPN for any cause and that would predictably continue with TPN for at least five days. The study included 161 patients who started with TPN for any cause. There were 80 patients (49.7%) on fish oil enriched ILEs and 81 patients (50.3%) on other ILEs. We found significant decreases in triglyceride levels in the fish oil group compared to the other patients. We did not find any differences in glucose metabolic control: mean capillary glucose, glycemic variability, and insulin dose, except in the number of mild hypoglycemic events that was significantly higher in the fish oil group. We did not observe any differences in other metabolic, liver or infectious complications, in-hospital length of stay or mortality. View Full-Text
Keywords: parenteral nutrition; type 2 diabetes mellitus; polyunsaturated fatty acids; omega 3; hospital parenteral nutrition; type 2 diabetes mellitus; polyunsaturated fatty acids; omega 3; hospital
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Figure 1

MDPI and ACS Style

Abuín-Fernández, J.; Tapia-Guerrero, M.J.; López-Urdiales, R.; Herranz-Antolín, S.; García-Almeida, J.M.; García-Malpartida, K.; Ferrer-Gómez, M.; Cancer-Minchot, E.; Luengo-Pérez, L.M.; Álvarez-Hernández, J.; Aragón Valera, C.; Ocón-Bretón, J.; García-Manzanares, Á.; Bretón-Lesmes, I.; Serrano-Aguayo, P.; Pérez-Ferre, N.; López-Gómez, J.J.; Olivares-Alcolea, J.; Arraiza-Irigoyen, C.; Tejera-Pérez, C.; Martínez-González, J.D.; Urioste-Fondo, A.; Abad-González, Á.L.; Molina-Puerta, M.J.; Zugasti-Murillo, A.; Parra-Barona, J.; López-Cobo, I.; Olveira, G. Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study. Nutrients 2020, 12, 1566. https://doi.org/10.3390/nu12061566

AMA Style

Abuín-Fernández J, Tapia-Guerrero MJ, López-Urdiales R, Herranz-Antolín S, García-Almeida JM, García-Malpartida K, Ferrer-Gómez M, Cancer-Minchot E, Luengo-Pérez LM, Álvarez-Hernández J, Aragón Valera C, Ocón-Bretón J, García-Manzanares Á, Bretón-Lesmes I, Serrano-Aguayo P, Pérez-Ferre N, López-Gómez JJ, Olivares-Alcolea J, Arraiza-Irigoyen C, Tejera-Pérez C, Martínez-González JD, Urioste-Fondo A, Abad-González ÁL, Molina-Puerta MJ, Zugasti-Murillo A, Parra-Barona J, López-Cobo I, Olveira G. Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study. Nutrients. 2020; 12(6):1566. https://doi.org/10.3390/nu12061566

Chicago/Turabian Style

Abuín-Fernández, Jose; Tapia-Guerrero, María J.; López-Urdiales, Rafael; Herranz-Antolín, Sandra; García-Almeida, Jose M.; García-Malpartida, Katherine; Ferrer-Gómez, Mercedes; Cancer-Minchot, Emilia; Luengo-Pérez, Luis M.; Álvarez-Hernández, Julia; Aragón Valera, Carmen; Ocón-Bretón, Julia; García-Manzanares, Álvaro; Bretón-Lesmes, Irene; Serrano-Aguayo, Pilar; Pérez-Ferre, Natalia; López-Gómez, Juan J.; Olivares-Alcolea, Josefina; Arraiza-Irigoyen, Carmen; Tejera-Pérez, Cristina; Martínez-González, Jorge D.; Urioste-Fondo, Ana; Abad-González, Ángel L.; Molina-Puerta, María J.; Zugasti-Murillo, Ana; Parra-Barona, Juan; López-Cobo, Irela; Olveira, Gabriel. 2020. "Fish Oil Enriched Intravenous Lipid Emulsions Reduce Triglyceride Levels in Non-Critically Ill Patients with TPN and Type 2 Diabetes. A Post-Hoc Analysis of the INSUPAR Study" Nutrients 12, no. 6: 1566. https://doi.org/10.3390/nu12061566

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