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Open AccessArticle

Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa

1
Department of Experimental Medicine, Section of Medical Physiopathology, Food Science and Endocrinology, “Sapienza” University of Rome, Rome, Italy
2
Department of Molecular Medicine, “Sapienza” University of Rome, 00161 Rome, Italy
3
Department of Epidemiology, Lazio Regional Health Service, 00147 Rome, Italy
4
Internal Medicine, Santo Spirito in Sassia Hospital, 00193 Rome, Italy
5
Department of Mental Health, UOSD eating behavior disorders, Padiglione I, Comprensorio S. Maria della Pietà, 00135 Rome, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3506; https://doi.org/10.3390/nu12113506
Received: 16 October 2020 / Revised: 9 November 2020 / Accepted: 11 November 2020 / Published: 14 November 2020
(This article belongs to the Special Issue Dietary Influence on Adipose Tissue Metabolism and Blood Lipid Levels)
Sirtuin 1 (SIRT1) is a sensor of cell energy availability, and with leptin and adiponectin, it regulates metabolic homeostasis. Widely studied in tissues, SIRT1 is under evaluation as a plasmatic marker. We aimed at assessing whether circulating SIRT1 behaves consistently with leptin and adiponectin in conditions of deficiency, excess or normal fat content. Eighty subjects were evaluated: 27 with anorexia nervosa (AN), 26 normal-weight and 27 with obesity. Bloodstream SIRT1, leptin and adiponectin (ELISA), total and trunk fat mass (FM) %, abdominal visceral adipose tissue, liver steatosis and epicardial fat thickness (EFT) were assessed. For each fat store, the coefficient of determination (R2) was used to evaluate the prediction capability of SIRT1, leptin and adiponectin. Plasma SIRT1 and adiponectin coherently decreased with the increase of FM, while the opposite occurred with leptin. Mean levels of each analyte were different between groups (p < 0.005). A significant association between plasma variables and FM depots was observed. SIRT1 showed a good predictive strength for FM, particularly in the obesity group, where the best R2 was recorded for EFT (R2 = 0.7). Blood SIRT1, adiponectin and leptin behave coherently with FM and there is synchrony between them. The association of SIRT1 with FM is substantially superimposable to that of adiponectin and leptin. Given its homeostatic roles, SIRT1 may deserve to be considered as a plasma clinical/biochemical parameter of adiposity and metabolic health. View Full-Text
Keywords: adipose tissue; sirtuins; plasma SIRT1; adiponectin; leptin; anorexia nervosa; obesity adipose tissue; sirtuins; plasma SIRT1; adiponectin; leptin; anorexia nervosa; obesity
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MDPI and ACS Style

Mariani, S.; Di Giorgio, M.R.; Rossi, E.; Tozzi, R.; Contini, S.; Bauleo, L.; Cipriani, F.; Toscano, R.; Basciani, S.; Barbaro, G.; Watanabe, M.; Valenti, A.; Cotugno, A.; Ancona, C.; Lubrano, C.; Gnessi, L. Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa. Nutrients 2020, 12, 3506. https://doi.org/10.3390/nu12113506

AMA Style

Mariani S, Di Giorgio MR, Rossi E, Tozzi R, Contini S, Bauleo L, Cipriani F, Toscano R, Basciani S, Barbaro G, Watanabe M, Valenti A, Cotugno A, Ancona C, Lubrano C, Gnessi L. Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa. Nutrients. 2020; 12(11):3506. https://doi.org/10.3390/nu12113506

Chicago/Turabian Style

Mariani, Stefania; Di Giorgio, Maria R.; Rossi, Erica; Tozzi, Rossella; Contini, Savina; Bauleo, Lisa; Cipriani, Fiammetta; Toscano, Raffaella; Basciani, Sabrina; Barbaro, Giuseppe; Watanabe, Mikiko; Valenti, Agostino; Cotugno, Armando; Ancona, Carla; Lubrano, Carla; Gnessi, Lucio. 2020. "Blood SIRT1 Shows a Coherent Association with Leptin and Adiponectin in Relation to the Degree and Distribution of Adiposity: A Study in Obesity, Normal Weight and Anorexia Nervosa" Nutrients 12, no. 11: 3506. https://doi.org/10.3390/nu12113506

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