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Thalassemia Reports, Volume 14, Issue 1

March 2024 - 3 articles

Cover Story: In patients with sickle cell disease (SCD), transfusions pose risks like delayed hemolytic transfusion reaction (DHTR) and hyperhemolytic syndrome (HHS). We present the case of a 61-year-old Nigerian male patient with SCD, developing hyperhemolytic syndrome (HHS) post-orthopedic surgery due to alloimmunization from blood transfusions. Surgery induced massive hemorrhage, requiring RBC transfusions. Postoperatively, he developed HHS with jaundice, hemoglobinuria, and fever. Despite additional transfusions, his condition worsened, leading to hematological consultation on postoperative day +9. Laboratory findings showed positive DAT and multiple alloantibodies. The diagnosis of HHS was established, and treatment involved high-dose methylprednisolone, intravenous immunoglobulin (IVIG), and erythropoietin. View this paper

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Articles (3)

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Case Report

1 Citations

4,593 Views

8 Pages

A Case Report of Hyperhemolytic Syndrome in Sickle Cell Disease, with a Special Focus on Avoiding the Use of Transfusions

Omar Obajed Al-Ali,
György Pfliegler,
Ferenc Magyari,
Fanni Borics,
László Imre Pinczés,
Árpád Illés and
Boglárka Brúgós

Thalass. Rep.2024, 14(1), 18-25;https://doi.org/10.3390/thalassrep14010003

4 March 2024

In patients with sickle cell disease (SCD), transfusions pose risks like delayed hemolytic transfusion reaction (DHTR) and hyperhemolytic syndrome (HHS). We present the case of a 61-year-old Nigerian male patient with SCD, developing hyperhemolytic s...

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Article

3,485 Views

8 Pages

Causes of Hospitalizations in Pediatric Patients with Thalassemia under the National Health Coverage Scheme in Thailand

Pimlak Charoenkwan,
Patcharee Komvilaisak,
Kaewjai Thepsuthummarat,
Panya Seksarn and
Kitti Torcharus

Thalass. Rep.2024, 14(1), 10-17;https://doi.org/10.3390/thalassrep14010002

1 March 2024

Thalassemia is a hereditary hemolytic anemia that is prevalent in Southeast Asia. The primary treatment for severe thalassemia involves red cell transfusion, iron chelation, and the treatment of long-term complications, leading to frequent hospital v...

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Review

5 Citations

7,202 Views

9 Pages

Challenges of Iron Chelation in Thalassemic Children

Alkistis Adramerina and
Marina Economou

Thalass. Rep.2024, 14(1), 1-9;https://doi.org/10.3390/thalassrep14010001

1 February 2024

Thalassemia treatment still relies on supportive care, mainly including blood transfusion and iron chelation therapy. Iron chelation is considered the main factor responsible for the marked improvement in survival rates of thalassemic patients. Hemos...

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Thalass. Rep. - ISSN 2039-4365

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