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Thalassemia Reports, Volume 15, Issue 4

2025 December - 3 articles

Cover Story: The present study evaluated temporal changes in quality of life (QoL) and psychological burden among thalassemia patients in 2025, compared with 2018. Two cross-sectional samples of patients (n=236) were recruited during 2025 (n₁=117) and 2018 (n₂=119) at the Thalassemia Units on Crete/Greece. The EQ-5D-3L Quality of Life Scale, the EQ VAS Index, and the Hospital Anxiety and Depression Scale (HADS) were used through multiple logistic regression analysis to assess relative parameters. Health status and QoL remained consistent from 2018 to 2025, while depression levels increased. Anxiety significantly exceeded depression, and better QoL was associated with improved health status and reduced anxiety and depression. View this paper

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Articles (3)

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Article

1,533 Views

18 Pages

Epidemiological and Clinical Profile of Hemoglobinopathies and Thalassemia in Duhok, Kurdistan Region of Iraq: A Retrospective Study

Burhan Abdullah Zaman,
Zuhair Rushdi Mustafa,
Delshad Abdulah Mohamed,
Hasan Abdullah Aswad and
Deldar Morad Abdulah

Thalass. Rep.2025, 15(4), 12;https://doi.org/10.3390/thalassrep15040012

28 November 2025

Background/Objectives: Thalassemia is among the most common hereditary disorders globally, characterized by impaired hemoglobin synthesis and ineffective erythropoiesis. This study analyzed data on hemoglobinopathies, with a particular focus on thala...

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Article

698 Views

13 Pages

Temporal Changes in Quality of Life and Psychological Burden of Patients with Thalassemia: A Comparative Data Analysis from 2018 to 2025

Nikos Rikos,
Marilena Tzagkaraki,
Antigoni Linardaki,
Maria Moloudaki and
Manolis Linardakis

Thalass. Rep.2025, 15(4), 11;https://doi.org/10.3390/thalassrep15040011

6 November 2025

Background/Objectives: Thalassemia significantly affects the mental well-being and lifestyle of patients and their families. This study evaluated the temporal changes in quality of life (QoL) and psychological burden among thalassemia patients in 202...

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Review

1,109 Views

16 Pages

The Interplay Between β-Thalassemia and the Human Virome: Immune Dysregulation, Viral Reactivation, and Clinical Implications

Didar Hossain and
Mohammad Jakir Hosen

Thalass. Rep.2025, 15(4), 10;https://doi.org/10.3390/thalassrep15040010

3 October 2025

β-thalassemia is a chronic genetic blood disorder characterized by defective β-globin synthesis, requiring frequent transfusions and resulting in iron overload, immune dysfunction, and increased susceptibility to infections. In these immuno...

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Thalass. Rep. - ISSN 2039-4365

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