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Thalassemia Reports, Volume 15, Issue 3

2025 September - 3 articles

Cover Story: Anaemia and iron overload remain health concerns in the management of β-thalassemia, as uncontrolled transfusion and chelation introduce further complications. In this study, we report the therapeutic benefits of curcumin, also known as turmeric, in β-thalassemia. Although curcumin showed no effect on haemoglobin and red blood cells, it demonstrated potential clinical effects on serum ferritin, non-transferrin-bound iron, serum iron, reactive oxygen species, and malondialdehyde levels. The findings underscore the significance of curcumin in mitigating iron overload and oxidative stress in β-thalassemia. View this paper

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Articles (3)

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Article

1,258 Views

10 Pages

Comparing Spectrophotometric Hemoglobin Concentrations with Conventional Laboratory Cell Analyzers in Transfusion-Dependent Beta-Thalassemia Patients

Khaled Yassen,
Nawal Omar,
Abdulaziz Bushehab,
Renad AlSubaie,
Lina AlMudayris,
Sara A. Albunyan,
Shaima AlAkroush,
Sherif Saleh,
Dur I. Shahwar and
Ossama Zakaria

Thalass. Rep.2025, 15(3), 9;https://doi.org/10.3390/thalassrep15030009

10 September 2025

Background/Objectives: Thalassemias, a hereditary condition commonly linked to chronic anemia, require regular blood transfusions and repeated blood draws for assessments of hemoglobin (Hb) content, which can be uncomfortable. A promising substitute...

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Article

1,052 Views

8 Pages

The Distribution of HLA Alleles in Patients with Beta Thalassemia

Yasin Yilmaz,
Zeynep Karakas,
Ayse Erol Bozkurt,
Demet Kivanc,
Mediha Suleymanoglu,
Hayriye Senturk Ciftci,
Cigdem Kekik Cinar and
Fatma Savran Oguz

Thalass. Rep.2025, 15(3), 8;https://doi.org/10.3390/thalassrep15030008

27 August 2025

Background: It has been shown that human leucocyte antigen (HLA) alleles are related to certain diseases. Some alleles were associated with alloimmunization in individuals with thalassemia. In this study, we studied the distribution of HLA alleles am...

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Systematic Review

2 Citations

5,797 Views

21 Pages

Curcumin Therapy Reduces Iron Overload and Oxidative Stress in Beta-Thalassemia: Findings from a Meta-Analytic Study

Kabelo Mokgalaboni,
Wendy N. Phoswa,
Perpetua Modjadji and
Sogolo L. Lebelo

Thalass. Rep.2025, 15(3), 7;https://doi.org/10.3390/thalassrep15030007

2 July 2025

The risk of anemia and iron overload is a global concern in beta (β)-thalassemia. The β-thalassemia primary treatment includes blood transfusion and iron chelation therapy; however, both are associated with risks such as anemia, iron deplet...

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Thalass. Rep. - ISSN 2039-4365

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