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Hematology Reports
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  • Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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14 June 2017

Acute Myeloid Leukemia with RAM Immunophenotype: A Pediatric Case with Unusual Morphologic Features

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1
Department of Pathology and Laboratory Medicine, Nationwide Children’s Hospital, 700 Children's Drive, Columbus, OH 43205, USA
2
Division of Hematology/Oncology and Bone Marrow Transplant, Nationwide Children’s Hospital, 700 Children's Drive, Columbus, OH 43205, USA
3
Hematologics, Inc., Seattle, WA 98121, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep.2017, 9(2), 7057;https://doi.org/10.4081/hr.2017.7057
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Abstract

The RAM immunophenotype has been recently described as a subtype of acute myelogenous leukemia (AML) that is characterized clinically by extremely poor prognosis. We present a case of AML with RAM immunophenotype in a 5-year-old patient that resulted in poor outcome despite early hematopoietic cell transplant. We describe the unusual morphologic features that, along with the distinct immunophenotype, may provide initial diagnostic clues and further justify the classification of this AML variant as a rather distinct subtype.

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