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Hematology Reports, Volume 17, Issue 2

April 2025 - 12 articles

Cover Story: Leukemia is a heterogeneous group of hematologic malignancies characterized by distinct genetic and molecular abnormalities. Advancements in genomic technologies have significantly transformed the diagnosis, prognosis, and treatment strategies for leukemia. Among these, next-generation sequencing (NGS) has emerged as a powerful tool, enabling high-resolution genomic profiling that surpasses the conventional diagnostic approaches. This review highlights the impact of NGS on leukemia research and clinical applications, discussing its advantages over the traditional diagnostic techniques, key sequencing approaches, and emerging challenges. As precision oncology continues to evolve, NGS is expected to play an increasingly central role in the diagnosis and management of leukemia, driving innovations in personalized medicine and therapeutic interventions. View this paper
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Articles (12)

  • Case Report
  • Open Access
1,114 Views
6 Pages

Background: This case report investigates the effects of sotorasib treatment in a patient with acquired von Willebrand syndrome (AVWS) associated with monoclonal gammopathy of undetermined significance (MGUS), who subsequently developed non-small-cel...

  • Case Report
  • Open Access
1,255 Views
8 Pages

Background: Gamma-glutamylcysteine synthetase catalyzes the first and rate-limiting step in the synthesis of glutathione. Gamma-glutamylcysteine synthetase deficiency is a very rare condition that has so far been detected so far in nine patients from...

  • Article
  • Open Access
1,494 Views
8 Pages

Blood Coagulation Favors Anti-Inflammatory Immune Responses in Whole Blood

  • Victor I. Seledtsov,
  • Anatoly A. Pyshenko,
  • Tatyana Ya. Lyubavskaya,
  • Irina A. Seledtsova and
  • Alexei A. von Delwig

Background: We studied the effects of human blood coagulation on antioxidant activity and the cellular secretion of immunoregulatory molecules in vitro. Methods: Reactive oxygen species (ROS) activity and cytokine content were determined in plasma an...

  • Review
  • Open Access
7 Citations
4,619 Views
47 Pages

Genetic Profiling of Acute and Chronic Leukemia via Next-Generation Sequencing: Current Insights and Future Perspectives

  • Laras Pratiwi,
  • Fawzia Hanum Mashudi,
  • Mukti Citra Ningtyas,
  • Henry Sutanto and
  • Pradana Zaky Romadhon

Leukemia is a heterogeneous group of hematologic malignancies characterized by distinct genetic and molecular abnormalities. Advancements in genomic technologies have significantly transformed the diagnosis, prognosis, and treatment strategies for le...

  • Article
  • Open Access
757 Views
13 Pages

Primary Palatine Tonsil Non-Hodgkin Lymphoma in Western Romania: A Comparison of Lower-Stage and Advanced-Stage Disease

  • Raluca Morar,
  • Norberth-Istvan Varga,
  • Delia Ioana Horhat,
  • Ion Cristian Mot,
  • Nicolae Constantin Balica,
  • Alina-Andree Tischer,
  • Monica Susan,
  • Razvan Susan,
  • Diana Luisa Lighezan and
  • Rodica Anamaria Negrean

Background: Limited data exist on primary palatine tonsil Non-Hodgkin lymphoma (NHL) from regions with constrained healthcare access. This study investigated this malignancy in Western and South-Western Romania, comparing lower-stage (Ann-Arbor I-III...

  • Article
  • Open Access
1,096 Views
10 Pages

Treatment of Non-Hodgkin Lymphoma Involving Head and Neck Sites with a 1.5 T MR-Linac: Preliminary Results from a Prospective Observational Study

  • Andrea Emanuele Guerini,
  • Stefania Nici,
  • Stefano Riga,
  • Ludovica Pegurri,
  • Paolo Borghetti,
  • Eneida Mataj,
  • Jacopo Balduzzi,
  • Mirsada Katica,
  • Gianluca Cossali and
  • Giorgio Facheris
  • + 5 authors

Purpose: Lymphomas are generally radiosensitive; therefore, disease volume tends to shrink during radiotherapy courses. As MRI-linac provides excellent soft tissue definition and allows daily re-contouring of gross tumor volume and clinical target vo...

  • Communication
  • Open Access
4 Citations
1,536 Views
8 Pages

Avascular Necrosis of the Femoral Head in Patients with Antiphospholipid Syndrome: A Case Series

  • Paschalis Evangelidis,
  • Eleni Gavriilaki,
  • Nikolaos Kotsiou,
  • Zacharo Ntova,
  • Panagiotis Kalmoukos,
  • Theodosia Papadopoulou,
  • Sofia Chissan and
  • Sofia Vakalopoulou

Background/Objectives: Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombosis or obstetric complications and the laboratory detection of antiphospholipid antibodies. Although vascular thrombosis is the main manif...

  • Case Report
  • Open Access
848 Views
7 Pages

Background: Thymoma-associated pure white cell aplasia (PWCA), characterized by agranulocytosis with absent myeloid precursors in the bone marrow in the setting of preserved erythropoiesis and megakaryopoiesis, is exceedingly rare, with only a few ca...

  • Case Report
  • Open Access
998 Views
9 Pages

Aplastic anemia occurs with an incidence of 2–5: 1 million people worldwide. However, the frequency of newly diagnosed cases of bone marrow aplasia is greater, and some of these patients present to emergency departments initially. Description o...

  • Case Report
  • Open Access
1,468 Views
7 Pages

Introduction: Heparin-induced thrombocytopenia (HIT) is an autoimmune life-threatening prothrombotic syndrome associated with low platelet count after heparin exposure. Spontaneous heparin-induced thrombocytopenia (S-HIT) is an even less frequent var...

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Hematol. Rep. - ISSN 2038-8330Creative Common CC BY license