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Microbiology Research
Volume 17
Issue 2
10.3390/microbiolres17020038
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Article

Identification and Characterization of Two Antibacterial Compounds Extracted from Thuja arborvitae

by
Tory M. Johnson
1,
Quanbo Xiong
2 and
Zhengxin Wang
1,*
1
Center for Cancer Research and Therapeutic Development, Department of Biological Sciences, Clark Atlanta University, 223 James P. Brawley Drive, S.W., Atlanta, GA 30314, USA
2
Corteva Agriscience, 9330 Zionsville Road, Indianapolis, IN 46268, USA
*
Author to whom correspondence should be addressed.
Microbiol. Res. 2026, 17(2), 38; https://doi.org/10.3390/microbiolres17020038
Submission received: 10 December 2025 / Revised: 27 January 2026 / Accepted: 6 February 2026 / Published: 10 February 2026
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Abstract

Thuja arborvitae are widely grown in North America and East Asia for their ornamental value, and their leaf oil extracts have been used to treat bacterial infections. This study aimed to identify antibacterial compounds from Thuja leaves. The methanol extract of Thuja leaves exhibited strong antibacterial activity against Gram-positive (Staphylococcus aureus and Streptococcus mutans) and Gram-negative (Acinetobacter baumannii, Pseudomonas aeruginosa) bacteria. The major compounds in the active fractions were isolated and identified as apigenin-7-di-p-coumarylglucoside and eicosapentaenoic acid. The identified compounds showed potent antibacterial activity against the four tested microorganisms with IC50 values of 10 to 50 µg/mL. More importantly, these compounds showed potent inhibitory activity (IC50: 10 μg/mL) against the multidrug-resistant bacterial strain Acinetobacter baumannii. Two antibacterial compounds are now being reported for the first time in Thuja arborvitae, and they may have potential for the treatment of bacterial infections.
Keywords: apigenin-7-di-p-coumarylglucoside; eicosapentaenoic acid; Thuja arborvitae; antibiotics apigenin-7-di-p-coumarylglucoside; eicosapentaenoic acid; Thuja arborvitae; antibiotics

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MDPI and ACS Style

Johnson, T.M.; Xiong, Q.; Wang, Z. Identification and Characterization of Two Antibacterial Compounds Extracted from Thuja arborvitae. Microbiol. Res. 2026, 17, 38. https://doi.org/10.3390/microbiolres17020038

AMA Style

Johnson TM, Xiong Q, Wang Z. Identification and Characterization of Two Antibacterial Compounds Extracted from Thuja arborvitae. Microbiology Research. 2026; 17(2):38. https://doi.org/10.3390/microbiolres17020038

Chicago/Turabian Style

Johnson, Tory M., Quanbo Xiong, and Zhengxin Wang. 2026. "Identification and Characterization of Two Antibacterial Compounds Extracted from Thuja arborvitae" Microbiology Research 17, no. 2: 38. https://doi.org/10.3390/microbiolres17020038

APA Style

Johnson, T. M., Xiong, Q., & Wang, Z. (2026). Identification and Characterization of Two Antibacterial Compounds Extracted from Thuja arborvitae. Microbiology Research, 17(2), 38. https://doi.org/10.3390/microbiolres17020038

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