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Neurology International, Volume 15, Issue 2

June 2023 - 15 articles

Cover Story: The cognitive deficits of long-COVID include the dysfunction of the dorsolateral prefrontal cortex (dlPFC), which is especially vulnerable to inflammation. dlPFC neurotransmission requires NMDA and nicotinic α7 receptors, which are both blocked by kynurenic acid during inflammation. dlPFC neurons also express high levels of cAMP-calcium signaling during inflammation, opening K⁺ channels to reduce neuronal firing. These detrimental actions are lessened by agents that inhibit kynurenic acid production, e.g., N-acety-cysteine (NAC), and regulate cAMP-calcium-K⁺ channel signaling, e.g., the α2-adrenoceptor agonist, guanfacine. Guanfacine is also anti-inflammatory, deactivating glia, and NAC protects mitochondria from oxidative stress. Open label data suggest these agents can ameliorate the cognitive deficits of long-COVID, indicating a path forward for this debilitating disorder. View this paper

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Review

48 Citations

5,309 Views

14 Pages

Macrophages in Recurrent Glioblastoma as a Prognostic Factor in the Synergistic System of the Tumor Microenvironment

Nicola Montemurro,
Bhavya Pahwa,
Anish Tayal,
Anushruti Shukla,
Manuel De Jesus Encarnacion,
Issael Ramirez,
Renat Nurmukhametov,
Vishal Chavda and
Antonella De Carlo

Neurol. Int.2023, 15(2), 595-608;https://doi.org/10.3390/neurolint15020037

23 April 2023

Glioblastoma (GBM) is a common and highly malignant primary tumor of the central nervous system in adults. Ever more recent papers are focusing on understanding the role of the tumor microenvironment (TME) in affecting tumorigenesis and the subsequen...

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Article

3 Citations

3,868 Views

15 Pages

Sensory Motor Function Disturbances in Mice Prenatally Exposed to Low Dose of Ethanol: A Neurobehavioral Study in Postnatal and Adult Stages

Kamal Smimih,
Bilal El-Mansoury,
Fatima Ez-Zahraa Saad,
Manal Khanouchi,
Souad El Amine,
Abdelmohcine Aimrane,
Nadia Zouhairi,
Abdessalam Ferssiwi,
Abdelali Bitar and
Mohamed Merzouki
+ 1 author

Neurol. Int.2023, 15(2), 580-594;https://doi.org/10.3390/neurolint15020036

19 April 2023

Prenatal alcohol exposure (PAE) refers to fetal exposure to alcohol during pregnancy through placental barrier transfer from maternal blood. The postnatal outcomes of PAE differ among exposed individuals and range from overt (serious) alcohol-related...

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Case Report

12 Citations

9,058 Views

11 Pages

Post-Polio Syndrome Revisited

Michael Punsoni,
Nelli S. Lakis,
Michelle Mellion and
Suzanne M. de la Monte

Neurol. Int.2023, 15(2), 569-579;https://doi.org/10.3390/neurolint15020035

13 April 2023

Post-polio syndrome (PPS) is characterized by recrudescence or worsening of motor neuron disease symptoms decades after recovery from acute paralytic poliovirus infection, i.e., poliomyelitis. PPS afflicts between 25% and 40% of poliomyelitis survivo...

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Article

3 Citations

2,358 Views

9 Pages

The Discrepancy and Agreement between Patient-Reported Percentage Pain Reduction and Calculated Percentage Pain Reduction in Chronic Pain Patients

Adam B. Fink,
Charmaine Ong,
Moez K. Sumar,
Neil C. Patel and
Nebojsa Nick Knezevic

Neurol. Int.2023, 15(2), 560-568;https://doi.org/10.3390/neurolint15020034

4 April 2023

Two derivatives of the numeric rating scale (NRS) and visual analog scale (VAS), namely patient-reported percentage pain reduction (PRPPR) and calculated percentage pain reduction (CPPR), are commonly used when evaluating pain reduction. A small numb...

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Article

6 Citations

3,531 Views

11 Pages

Rapid Effects of BCI-Based Attention Training on Functional Brain Connectivity in Poststroke Patients: A Pilot Resting-State fMRI Study

Larisa Mayorova,
Anastasia Kushnir,
Viktoria Sorokina,
Pranil Pradhan,
Margarita Radutnaya,
Vasiliy Zhdanov,
Marina Petrova and
Andrey Grechko

Neurol. Int.2023, 15(2), 549-559;https://doi.org/10.3390/neurolint15020033

27 March 2023

The prevalence of stroke-induced cognitive impairment is high. Effective approaches to the treatment of these cognitive impairments after stroke remain a serious and perhaps underestimated challenge. A BCI-based task-focused training that results in...

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