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Neurology International, Volume 15, Issue 1

March 2023 - 32 articles

Cover Story: The rab2b gene is associated with autism spectrum disorder (ASD), although it remains unclear how it can cause ASD at the molecular and cellular levels. The important question of how cellular phenotypes of ASD can be recovered remains to be clarified. Here, this paper not only shows that Rab2b knockdown inhibits neuronal cell morphological differentiation, but also that its knockdown inhibits oligodendroglial cell morphological differentiation. Furthermore, hesperetin, a citrus flavonoid, recovers defective differentiation of neuronal and oligodendroglial cell differentiation. The underlying molecular mechanism involves the activation of classical mitogen-activated protein kinse (MAPK). Hesperetin may be considered as a chemical candidate for recovering ASD-associated neuronal and oligodendroglial cell morphogenesis. View this paper
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Articles (32)

  • Article
  • Open Access
3 Citations
3,003 Views
15 Pages

20 March 2023

In this study, we examined visual processing within primary visual areas (V1) in normal and visually impaired individuals who exhibit significant visual symptomology due to sports-related mild traumatic brain injury (mTBI). Five spatial frequency sti...

  • Review
  • Open Access
31 Citations
30,885 Views
16 Pages

Chronic Administration of Melatonin: Physiological and Clinical Considerations

  • Donald Givler,
  • Amy Givler,
  • Patrick M. Luther,
  • Danielle M. Wenger,
  • Shahab Ahmadzadeh,
  • Sahar Shekoohi,
  • Amber N. Edinoff,
  • Bradley K. Dorius,
  • Carlo Jean Baptiste and
  • Elyse M. Cornett
  • + 2 authors

15 March 2023

Background: Exogenous melatonin is commonly used to treat insomnia, other sleep problems, and numerous medical illnesses, including Alzheimer’s disease, autism spectrum disorder, and mild cognitive impairment in adults and children. There is ev...

  • Article
  • Open Access
2 Citations
3,406 Views
10 Pages

Clinical Features of Acute Ischemic Stroke Patients with Hypoesthesia as an Initial Symptom

  • Takayoshi Akimoto,
  • Katsuhiko Ogawa,
  • Makoto Hara,
  • Satoko Ninomiya,
  • Masaki Ishihara,
  • Akihiko Morita,
  • Satoshi Kamei and
  • Hideto Nakajima

15 March 2023

This study aimed to evaluate the clinical characteristics of acute ischemic stroke (AIS) patients who experienced hypoesthesia as the initial symptom. We retrospectively analyzed the medical records of 176 hospitalized AIS patients who met our inclus...

  • Review
  • Open Access
10 Citations
4,852 Views
11 Pages

Sleep and Chronobiology as a Key to Understand Cluster Headache

  • Laura Pilati,
  • Angelo Torrente,
  • Paolo Alonge,
  • Lavinia Vassallo,
  • Simona Maccora,
  • Andrea Gagliardo,
  • Antonia Pignolo,
  • Salvatore Iacono,
  • Salvatore Ferlisi and
  • Vincenzo Di Stefano
  • + 2 authors

15 March 2023

The cluster headache is a primary headache characterized by attacks of unilateral pain associated with ipsilateral cranial autonomic features. These attacks recur in clusters during the years alternating with periods of complete remission, and their...

  • Conference Report
  • Open Access
4,081 Views
82 Pages

14 March 2023

On behalf of the BraYn Association Ets, we are pleased to present the Abstracts of the Fifth Brainstorming Research Assembly for Young Neuroscientists, which was held in Rome, Italy from 28–30 September 2022. We congratulate all the presenters...

  • Article
  • Open Access
3 Citations
3,541 Views
10 Pages

10 March 2023

Background: Intravenous immunoglobulin (IVIg) is efficient and one of very few treatment options for patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). However, finding the optimal dose of IVIg for individual CIDP patient...

  • Review
  • Open Access
5 Citations
6,418 Views
13 Pages

The Role of Human Microbiota in Myasthenia Gravis: A Narrative Review

  • Giuseppe Schirò,
  • Salvatore Iacono and
  • Carmela Rita Balistreri

10 March 2023

Myasthenia gravis (MG) is an autoimmune neuromuscular disease characterized by fluctuating weakness of the skeletal muscles. Although antibodies against the neuromuscular junction components are recognized, the MG pathogenesis remains unclear, even i...

  • Article
  • Open Access
6 Citations
3,131 Views
21 Pages

Hesperetin Ameliorates Inhibition of Neuronal and Oligodendroglial Cell Differentiation Phenotypes Induced by Knockdown of Rab2b, an Autism Spectrum Disorder-Associated Gene Product

  • Yukino Kato,
  • Remina Shirai,
  • Katsuya Ohbuchi,
  • Hiroaki Oizumi,
  • Masahiro Yamamoto,
  • Wakana Miyata,
  • Tomoki Iguchi,
  • Yoshihiro Mimaki,
  • Yuki Miyamoto and
  • Junji Yamauchi

10 March 2023

Autism spectrum disorder (ASD) is a central nervous system (CNS) neurodevelopmental disorder that includes autism, pervasive developmental disorder, and Asperger’s syndrome. ASD is characterized by repetitive behaviors and social communication...

  • Case Report
  • Open Access
7 Citations
6,618 Views
9 Pages

Two Patients with Spontaneous Spinal Epidural Hematoma Carrying a Good Prognosis without Surgical Operations

  • Katsuhiko Ogawa,
  • Takayoshi Akimoto,
  • Makoto Hara,
  • Midori Fujishiro,
  • Hiroshi Uei and
  • Hideto Nakajima

7 March 2023

(1) Introduction: Spontaneous spinal epidural hematoma (SSEH) points to hematoma within the epidural space of the spinal cord without traumatic or iatrogenic causes. (2) Case Reports: One patient showed paraplegia, numbness of both legs with acute on...

  • Review
  • Open Access
2 Citations
3,802 Views
10 Pages

Ketamine Evolving Clinical Roles and Potential Effects with Cognitive, Motor and Driving Ability

  • Amber N. Edinoff,
  • Saveen Sall,
  • Colby B. Koontz,
  • Ajah K. Williams,
  • DeMarcus Drumgo,
  • Aya Mouhaffel,
  • Elyse M. Cornett,
  • Kevin S. Murnane and
  • Alan D. Kaye

3 March 2023

While driving under the influence of drugs, drivers are more likely to be involved in and cause more accidents than drivers who do not drive under the influence. Ketamine is derived from phencyclidine and acts as a noncompetitive antagonist and allos...

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Neurol. Int. - ISSN 2035-8377