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Neurology International, Volume 14, Issue 4

2022 December - 23 articles

Cover Story: This study aimed to investigate the accuracy and clinical significance of an artificial intelligence (AI)-based automated Alberta Stroke Program Early Computed Tomography (ASPECT) scoring software of head CT for the indication of intravenous recombinant tissue plasminogen activator (rt-PA) therapy. The comparison was done on a population of 448 patients with a CT scan obtained within 48h of presentation and a population of 132 patients with a scan obtained within 4.5h of presentation. The AI-based performance was comparable to that of the board-certified vascular neurologists in both populations. Finally, we propose an algorithm for selecting patients for the indication of rt-PA, based on the AI-based ASPECT score. View this paper
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Articles (23)

  • Article
  • Open Access
6 Citations
4,108 Views
19 Pages

Hypomyelinating Leukodystrophy 10 (HLD10)-Associated Mutations of PYCR2 Form Large Size Mitochondria, Inhibiting Oligodendroglial Cell Morphological Differentiation

  • Tomohiro Torii,
  • Remina Shirai,
  • Risa Kiminami,
  • Satoshi Nishino and ,
  • Takanari Sato,
  • Sui Sawaguchi,
  • Nana Fukushima,
  • Yoichi Seki,
  • Yuki Miyamoto and
  • Junji Yamauchi
  • + 5 authors+ 0 author

16 December 2022

Hypomyelinating leukodystrophy 10 (HLD10) is an autosomal recessive disease related to myelin sheaths in the central nervous system (CNS). In the CNS, myelin sheaths are derived from differentiated plasma membranes of oligodendrocytes (oligodendrogli...

  • Review
  • Open Access
27 Citations
5,183 Views
16 Pages

EEG in Neurorehabilitation: A Bibliometric Analysis and Content Review

  • Athanasia Tsiamalou,
  • Efthimios Dardiotis,
  • Konstantinos Paterakis,
  • George Fotakopoulos and ,
  • Ioannis Liampas,
  • Markos Sgantzos,
  • Vasileios Siokas and
  • Alexandros G. Brotis
  • + 3 authors+ 0 author

16 December 2022

Background: There is increasing interest in the role of EEG in neurorehabilitation. We primarily aimed to identify the knowledge base through highly influential studies. Our secondary aims were to imprint the relevant thematic hotspots, research tren...

  • Article
  • Open Access
2 Citations
2,689 Views
10 Pages

The Effect of Trunk Position on Attentional Disengagement in Unilateral Spatial Neglect

  • Kohei Shida,
  • Kazu Amimoto,
  • Kazuhiro Fukata,
  • Shinpei Osaki and ,
  • Hidetoshi Takahashi and
  • Shigeru Makita
  • + 1 author+ 0 author

13 December 2022

Unilateral spatial neglect (USN) causes difficulties in disengaging attention from the right side to unexpected targets on the left. However, the relationship between egocentric spatial position and attentional disengagement remains unclear. Therefor...

  • Article
  • Open Access
4 Citations
4,034 Views
12 Pages

Safety of Deep Repetitive Transcranial Magnetic Stimulation (drTMS) against Medical Refractory Symptoms in Parkinson Syndromes: First German Real-World Data with a Specific H5 Coil

  • Celine Cont,
  • Annaliis Lehto,
  • Nathalie Stute,
  • Anastasia Galli and ,
  • Christina Schulte,
  • Veronika Deer,
  • Michaela Wessler and
  • Lars Wojtecki
  • + 3 authors+ 0 author

12 December 2022

So far, deep repetitive transcranial magnetic stimulation (drTMS) has shown promising results as an add-on treatment for Parkinson’s disease (PD) but not for non-idiopathic Parkinson Syndromes (PS). We aimed to investigate the safety and feasib...

  • Case Report
  • Open Access
2 Citations
3,560 Views
6 Pages

Hemispheric Asymmetry on the Electroencephalogram during General Anesthesia Responsive to Blood Pressure Manipulations

  • Bryan T. Nycz,
  • Andrew Chalhoub,
  • Gaurav P. Patel,
  • Cassandra E. Dean and
  • Alexander Papangelou

7 December 2022

The electroencephalogram (EEG) has been extensively used to detect ischemia and the need for shunting during carotid endarterectomy. Limited literature exists using EEG data to detect ischemia in other surgeries. This case report depicts a 65-year-ol...

  • Article
  • Open Access
9 Citations
4,501 Views
11 Pages

7 December 2022

This retrospective chart review study explored the etiology, use, and yield of the etiological investigations of 651 children and adolescents diagnosed with borderline intellectual functioning (BIF). Neurological, neurodevelopmental, or neuropsychiat...

(This article belongs to the Special Issue Global Burden of Neurological Disorder)
  • Systematic Review
  • Open Access
4,473 Views
10 Pages

Relevance of Fluorodopa PET Scan in Dopamine Responsive Dystonia and Juvenile Parkinsonism: A Systematic Review

  • Juan A. Moncayo,
  • Maite Vargas,
  • Juan F. Ortiz,
  • Pablo Granda and ,
  • Alex S. Aguirre,
  • Jennifer Argudo,
  • Willians Tambo,
  • Gabriela Garofalo,
  • Christian John Capirig and
  • Luis G. Rueda
  • + 6 authors+ 1 author

2 December 2022

Background: Dopamine Responsive Dystonia (DRD) and Juvenile Parkinsonism (JP) are two diseases commonly presenting with parkinsonian symptoms in young patients. Current clinical guidelines offer a diagnostic approach based on molecular analysis. Howe...

(This article belongs to the Collection Brain Health Initiative: Advocacy in Global Neurology)
  • Case Report
  • Open Access
8 Citations
4,238 Views
6 Pages

Anti-MOG Positive Bilateral Optic Neuritis and Brainstem Encephalitis Secondary to COVID-19 Infection: A Case Report

  • Zisis Tsouris,
  • Antonios Provatas,
  • Christos Bakirtzis,
  • Athina-Maria Aloizou and ,
  • Vasileios Siokas,
  • Vana Tsimourtou,
  • Nikolaos Grigoriadis,
  • Georgios M. Hadjigeorgiou and
  • Efthimios Dardiotis
  • + 4 authors+ 0 author

30 November 2022

(1) Introduction: There have been numerous reports on the neuroinvasive competence of SARS-CoV-2. Here, we present a case with anti-MOG positive bilateral optic neuritis and brainstem encephalitis secondary to COVID-19 infection. Additionally, we pre...

(This article belongs to the Collection Advances in Neurodegenerative Diseases)
  • Article
  • Open Access
4 Citations
3,470 Views
10 Pages

The Utility of Automated ASPECTS in Acute Ischemic Stroke for Intravenous Recombinant Tissue Plasminogen Activator (IV-rtPA) Therapy

  • Soichiro Shibata,
  • Kenzo Sakurai,
  • Keiji Tachikawa,
  • Riyoko Ko and ,
  • Sakae Hino,
  • Takayuki Fukano,
  • Kenji Isahaya,
  • Takafumi Haraguchi,
  • Junji Yamauchi and
  • Yoshihisa Yamano
  • + 12 authors+ 7 authors

21 November 2022

Purpose: This study aimed to investigate the accuracy and clinical significance of an artificial intelligence (AI)-based automated Alberta Stroke Program Early Computed Tomography (ASPECT) scoring software of head CT for the indication of intravenous...

(This article belongs to the Special Issue Stroke: From Pathophysiology to Therapy)
  • Systematic Review
  • Open Access
15 Citations
5,140 Views
29 Pages

The Clinical Utility of Leukoaraiosis as a Prognostic Indicator in Ischemic Stroke Patients

  • Foteini Christidi,
  • Dimitrios Tsiptsios,
  • Anastasia Sousanidou,
  • Stefanos Karamanidis and ,
  • Sofia Kitmeridou,
  • Stella Karatzetzou,
  • Souzana Aitsidou,
  • Konstantinos Tsamakis,
  • Evlampia A. Psatha and
  • Konstantinos Vadikolias
  • + 8 authors+ 3 authors

17 November 2022

Stroke constitutes a major cause of functional disability with increasing prevalence among adult individuals. Thus, it is of great importance for both clinicians and stroke survivors to be provided with a timely and accurate prognostication of functi...

(This article belongs to the Special Issue Stroke: From Pathophysiology to Therapy)
  • Article
  • Open Access
4 Citations
2,863 Views
9 Pages

Humoral Response to SARS-CoV-2 Antigen in Patients Treated with Monoclonal Anti-CD20 Antibodies: It Is Not All about B Cell Recovery

  • Julia Feige,
  • Klaus Berek,
  • Michael Seiberl,
  • Patrick Hilpold and ,
  • Wolfgang Hitzl,
  • Franziska Di Pauli,
  • Harald Hegen,
  • Florian Deisenhammer,
  • Eugen Trinka and
  • Tobias Moser
  • + 7 authors+ 2 authors

16 November 2022

Anti-CD20 therapies decrease the humoral response to SARS-CoV-2 immunization. We aimed to determine the extent of the humoral response to SARS-CoV-2 antigens in correlation with peripheral B-cell dynamics among patients with central nervous system in...

(This article belongs to the Special Issue COVID-19, Neuroinflammation and Therapeutics)
  • Systematic Review
  • Open Access
6 Citations
2,901 Views
20 Pages

Elucidating the Role of Baseline Leukoaraiosis on Forecasting Clinical Outcome of Acute Ischemic Stroke Patients Undergoing Reperfusion Therapy

  • Stella Karatzetzou,
  • Dimitrios Tsiptsios,
  • Anastasia Sousanidou,
  • Foteini Christidi and ,
  • Evlampia A. Psatha,
  • Marilena Chatzaki,
  • Sofia Kitmeridou,
  • Erasmia Giannakou,
  • Efstratios Karavasilis and
  • Konstantinos Vadikolias
  • + 7 authors+ 2 authors

10 November 2022

Stroke stands as a major cause of death and disability with increasing prevalence. The absence of clinical improvement after either intravenous thrombolysis (IVT) or mechanical thrombectomy (MT) represents a frequent concern in the setting of acute i...

(This article belongs to the Collection Biomarkers in Stroke Prognosis)
  • Article
  • Open Access
3 Citations
3,488 Views
20 Pages

Association of Lesion Topography with Functional Outcomes in Acute Ischemic Stroke Patients Considered for, or Receiving, Reperfusion Therapy: A Meta-Analysis

  • Shuyue Chen,
  • Kevin J. Spring,
  • Murray C. Killingsworth,
  • Zeljka Calic and ,
  • Roy G. Beran and
  • Sonu M. M. Bhaskar
  • + 1 author+ 0 author

7 November 2022

Background: The impact of lesion topography (LT), characterised by the Alberta Stroke Programme Early CT Score (ASPECTS), on outcomes after reperfusion therapy in acute ischemic stroke (AIS) is poorly elucidated. We investigated the prognostic accura...

(This article belongs to the Special Issue Stroke: From Pathophysiology to Therapy)
  • Article
  • Open Access
22 Citations
9,033 Views
9 Pages

Anatomical Variations of the Sciatic Nerve Exit from the Pelvis and Its Relationship with the Piriformis Muscle: A Cadaveric Study

  • Juan Pablo Reynoso,
  • Manuel De Jesus Encarnacion,
  • Renat Nurmukhametov,
  • Dmitry Melchenko and ,
  • Ibrahim E. Efe,
  • Evgeniy Goncharov,
  • Angel Alfonso Taveras,
  • Issael Jesus Ramirez Pena and
  • Nicola Montemurro
  • + 4 authors+ 0 author

31 October 2022

Background: The sciatic nerve (SN) is the widest nerve of the human body that exits the pelvis through the greater sciatic foramen, usually below the piriformis muscle (PM), and descends between the greater trochanter of the femur and ischial tuberos...

  • Review
  • Open Access
14 Citations
18,722 Views
10 Pages

Lights on for Autism: Exploring Photobiomodulation as an Effective Therapeutic Option

  • Catherine Hamilton,
  • Ann Liebert,
  • Vincent Pang,
  • Pierre Magistretti and
  • John Mitrofanis

27 October 2022

Autism is a neurodevelopmental condition that starts in childhood and continues into adulthood. The core characteristics include difficulties with social interaction and communication, together with restricted and repetitive behaviours. There are a n...

(This article belongs to the Collection Advances in Neurodegenerative Diseases)
  • Article
  • Open Access
15 Citations
7,663 Views
9 Pages

Twelve-Month Results from a Prospective Clinical Study Evaluating the Efficacy and Safety of Cellular Bone Allograft in Subjects Undergoing Lumbar Spinal Fusion

  • Joshua Wind,
  • Daniel Park,
  • Todd Lansford,
  • Pierce Nunley and ,
  • Timothy Peppers,
  • Anthony Russo,
  • Hamid Hassanzadeh,
  • Jonathan N. Sembrano,
  • Jung Yoo and
  • Jonathan Sales
  • + 5 authors+ 0 author

26 October 2022

Background: While autologous bone grafts remain the gold standard for spinal fusion procedures, harvesting autologous bone is associated with significant complications, including donor site infection, hematomas, increased operative time, and prolonge...

  • Review
  • Open Access
32 Citations
8,973 Views
34 Pages

Diffusion Tensor Imaging as a Prognostic Tool for Recovery in Acute and Hyperacute Stroke

  • Foteini Christidi,
  • Dimitrios Tsiptsios,
  • Aggeliki Fotiadou,
  • Sofia Kitmeridou and ,
  • Stella Karatzetzou,
  • Konstantinos Tsamakis,
  • Anastasia Sousanidou,
  • Evlampia A. Psatha,
  • Efstratios Karavasilis and
  • Konstantinos Vadikolias
  • + 8 authors+ 3 authors

21 October 2022

Stroke represents a major cause of mortality and long-term disability among adult populations, leaving a devastating socioeconomic impact globally. Clinical manifestation of stroke is characterized by great diversity, ranging from minor disability to...

(This article belongs to the Special Issue Stroke: From Pathophysiology to Therapy)
  • Article
  • Open Access
6 Citations
4,217 Views
15 Pages

Where Am I? Searching for the Tangle in the Developmental Topographical Disorientation

  • Laura Piccardi,
  • Vincenza Cofini,
  • Massimiliano Palmiero,
  • Paola Verde and ,
  • Maddalena Boccia,
  • Liana Palermo,
  • Cecilia Guariglia and
  • Raffaella Nori
  • + 3 authors+ 0 author

20 October 2022

The Developmental Topographical Disorientation (DTD) is a pathological condition that impairs an individual’s ability to orient in space, even in the most familiar environments. It is a lifelong selective condition in individuals without brain...

  • Article
  • Open Access
6 Citations
3,981 Views
20 Pages

Radix Glycyrrhizae Preparata Induces Cell Cycle Arrest and Induced Caspase-Dependent Apoptosis in Glioblastoma Multiforme

  • Tsung-Ying Lin,
  • Tung-Hsuan Wu,
  • Rong-Dar Tzou,
  • Yi-Chiang Hsu and ,
  • Kuan-Ting Lee and
  • Tai-Hsin Tsai
  • + 1 author+ 0 author

13 October 2022

Glioblastoma multiforme (GBM) is a highly aggressive and devastating brain tumor characterized by poor prognosis and high rates of recurrence. Despite advances in multidisciplinary treatment, GBM constinues to have a poor overall survival. The Radix...

(This article belongs to the Topic Novel Diagnostic and Therapeutic Strategies in Gliomas)
  • Review
  • Open Access
34 Citations
7,802 Views
20 Pages

Stroke and Emerging Blood Biomarkers: A Clinical Prospective

  • Aimilios Gkantzios,
  • Dimitrios Tsiptsios,
  • Stella Karatzetzou,
  • Sofia Kitmeridou and ,
  • Vaia Karapepera,
  • Erasmia Giannakou,
  • Penelope Vlotinou,
  • Nikolaos Aggelousis and
  • Konstantinos Vadikolias
  • + 4 authors+ 0 author

22 September 2022

Stroke constitutes the primary source of adult functional disability, exhibiting a paramount socioeconomic burden. Thus, it is of great importance that the prediction of stroke outcome be both prompt and accurate. Although modern neuroimaging and neu...

(This article belongs to the Special Issue Stroke: From Pathophysiology to Therapy)
  • Article
  • Open Access
8 Citations
3,414 Views
13 Pages

21 September 2022

Humans tend to misrepresent spatial information which leads to systematic errors due to distorted organizational processes regarding metric and positional judgments. This study is aimed at analyzing metric and positional distortions in cognitive maps...

  • Article
  • Open Access
27 Citations
5,453 Views
23 Pages

20 September 2022

Background: Brain clots retrieved following endovascular thrombectomy in acute ischemic stroke patients may offer unique opportunities to characterise stroke aetiology and aid stroke decision-making in select groups of patients. However, the evidence...

(This article belongs to the Special Issue Stroke: From Pathophysiology to Therapy)
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Neurol. Int. - ISSN 2035-8377