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Neurology International, Volume 14, Issue 1

2022 March - 24 articles

Cover Story: Pelizaeus–Merzbacher disease is the prototypic hereditary central nervous system hypomyelinating and demyelinating diseases and is now commonly referred to as hypomyelinating leukodystrophy 1 (HLD1). This study for the first time describes abnormal lysosomal localization and accumulation of HLD8-associated mutated proteins of cytoplasmic POLR3B, which is a major subunit of RNA polymerase III. The mutated POLR3B proteins inhibit oligodendroglial cell morphological differentiation with decreased lysosome-related signaling through mTOR. Ibuprofen, which is a NSAID, improves the defects in their differentiation phenotypes and mTOR signaling. These findings may reveal some of the molecular and cellular pathological mechanisms underlying HLD8 and the amelioration. View this paper.
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Articles (24)

  • Review
  • Open Access
20 Citations
6,662 Views
16 Pages

Antipsychotic Polypharmacy-Related Cardiovascular Morbidity and Mortality: A Comprehensive Review

  • Amber N. Edinoff,
  • Emily D. Ellis,
  • Laura M. Nussdorf,
  • Taylor W. Hill,
  • Elyse M. Cornett,
  • Adam M. Kaye and
  • Alan D. Kaye

17 March 2022

Schizophrenia is a psychotic disorder that exists at the more extreme end of a spectrum of diseases, and significantly affects daily functioning. Cardiovascular adverse effects of antipsychotic medications are well known, and include changes in blood...

  • Article
  • Open Access
15 Citations
4,715 Views
10 Pages

Neuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study

  • Fernando Gracia,
  • Deyanira Ramírez,
  • Alexander Parajeles-Vindas,
  • Alejandro Díaz,
  • Amado Díaz de la Fé,
  • Nicia Eunice Ramírez Sánchez,
  • Romy Castro Escobar,
  • Luis Alberto García Valle,
  • Roberto Weiser and
  • Victor M. Rivera
  • + 27 authors

17 March 2022

Here, a study of NMOSD in Central America and the Caribbean with a multinational collaborative, multicentric and descriptive approach involving 25 institutions from 9 countries is presented. Demographics, clinical manifestations, expanded disability...

  • Article
  • Open Access
7 Citations
5,721 Views
13 Pages

Evaluating Therapeutic Equivalence of Generic and Original Levetiracetam in Patients with Epilepsy: A Retrospective Study

  • Jannapas Tharavichitkun,
  • Tinonkorn Yadee,
  • Poomchai Angkaow and
  • Thanarat Suansanae

15 March 2022

The brand interchangeability of antiepileptic drugs (AEDs) is a topic of debate, especially regarding their therapeutic equivalence. This study evaluates the efficacy and tolerability of generic levetiracetam compared to the brand-name equivalent in...

  • Article
  • Open Access
5 Citations
5,929 Views
10 Pages

3 March 2022

Background: Infantile spasms are an age-specific epileptic disorder. They occur in infancy and early childhood. They can be caused by multiple etiologies. Structural abnormalities represent an important cause of infantile spasms. Brain magnetic reson...

  • Article
  • Open Access
4 Citations
3,302 Views
11 Pages

Neurological Screening in Elderly Liver Transplantation Candidates: A Single Center Experience

  • Federica Avorio,
  • Gianvincenzo Sparacia,
  • Giovanna Russelli,
  • Aurelio Seidita,
  • Giuseppe Mamone,
  • Rossella Alduino,
  • Fabio Tuzzolino,
  • Salvatore Gruttadauria,
  • Roberto Miraglia and
  • Vincenzina Lo Re
  • + 1 author

25 February 2022

Background: Cerebral small vessels disease (cSVD) is an age-related disorder and risk factor for stroke and cognitive/motor impairments. Neurological complications (NCs) are among the causes of adverse outcomes in older liver transplant recipients. T...

  • Article
  • Open Access
2 Citations
4,734 Views
33 Pages

Hypomyelinating Leukodystrophy 8 (HLD8)-Associated Mutation of POLR3B Leads to Defective Oligodendroglial Morphological Differentiation Whose Effect Is Reversed by Ibuprofen

  • Sui Sawaguchi,
  • Rimi Suzuki,
  • Hiroaki Oizumi,
  • Katsuya Ohbuchi,
  • Kazushige Mizoguchi,
  • Masahiro Yamamoto,
  • Yuki Miyamoto and
  • Junji Yamauchi

16 February 2022

POLR3B and POLR3A are the major subunits of RNA polymerase III, which synthesizes non-coding RNAs such as tRNAs and rRNAs. Nucleotide mutations of the RNA polymerase 3 subunit b (polr3b) gene are responsible for hypomyelinating leukodystrophy 8 (HLD8...

  • Case Report
  • Open Access
3 Citations
3,810 Views
5 Pages

Clinical and Genetic Analysis of a Patient with CMT4J

  • Leema Reddy Peddareddygari and
  • Raji P. Grewal

10 February 2022

We report the clinical and genetic analysis of a patient with a rare form of an autosomal recessive genetic neuropathy, Charcot Marie Tooth (CMT) disease type 4J. She presented at age 62 years with signs and symptoms consistent with a mild neuropathy...

  • Article
  • Open Access
11 Citations
3,536 Views
8 Pages

Serum CGRP Changes following Ultrasound-Guided Bilateral Greater-Occipital-Nerve Block

  • Abdelrahman Abbas,
  • Ramez Moustafa,
  • Ali Shalash,
  • Mahmoud Haroun,
  • Randa Amin,
  • Sherien Borham,
  • Ahmed Elsadek and
  • Shahinaz Helmy

7 February 2022

Background: Calcitonin-gene-related peptide (CGRP) and CGRP receptors are expressed in trigeminal nerve cells, and treatments targeting CGRP are effective in migraines. For headaches that do not respond to pharmacological treatment, minimally invasiv...

  • Review
  • Open Access
15 Citations
13,624 Views
13 Pages

Oxytocin, a Novel Treatment for Methamphetamine Use Disorder

  • Amber N. Edinoff,
  • Elliot Thompson,
  • Chandler E. Merriman,
  • Mark R. Alvarez,
  • E. Saunders Alpaugh,
  • Elyse M. Cornett,
  • Kevin S. Murnane,
  • Rachel L. Kozinn,
  • Mila Shah-Bruce and
  • Alan D. Kaye
  • + 1 author

30 January 2022

The treatment of substance abuse with oxytocin is a novel approach to a challenging public health issue that continues to contribute to a growing economic cost for societies worldwide. Methamphetamine addiction is one of the leading causes of mortali...

  • Case Report
  • Open Access
4 Citations
7,239 Views
10 Pages

Neuroimaging and CSF Findings in Patients with Autoimmune Encephalitis: A Report of Eight Cases in a Single Academic Center

  • Hongyan Wu,
  • Hongxuyang Yu,
  • Joe Joseph,
  • Shruti Jaiswal,
  • Shreya R. Pasham and
  • Shitiz Sriwastava

28 January 2022

Autoimmune Encephalitis (AIE) is a rare and complex group of disorders wherein the body’s immune system attacks and causes inflammatory changes in the central nervous system (CNS). It presents with altered mental status and a diverse range of t...

  • Communication
  • Open Access
2 Citations
4,406 Views
10 Pages

Extending Thrombolysis in Acute Ischemic Stroke to Primary Care: Early Experiences with a Network-Based Teleneurology Approach

  • Francesco Corea,
  • Monica Acciarresi,
  • Laura Bernetti,
  • Pierluigi Brustenghi,
  • Arianna Guidubaldi,
  • Mariangela Maiotti,
  • Sara Micheli,
  • Vilma Pierini,
  • Alessio Gamboni and
  • Mauro Zampolini
  • + 6 authors

21 January 2022

Background and Purpose—Systemic thrombolysis represents the main proven therapy for acute ischemic stroke, but safe treatment is reported only in well-established stroke units. To extend the use of tissue plasminogen activator (tPA) treatment i...

  • Case Report
  • Open Access
1 Citations
5,312 Views
6 Pages

Headache Attributed to Temporomandibular Disorder and Primary Cough Headache

  • Keita Takizawa,
  • Kentaro Urata,
  • Rena Tanaka,
  • Kana Ozasa,
  • Andrew Young and
  • Noboru Noma

17 January 2022

Orofacial pain is a frequent chief complaint of many systemic disorders. A primary cough headache may mimic the clinical symptoms of a temporomandibular disorder (TMD) or may be associated with TMDs. Case report: A 52-year-old man presented with a 1-...

  • Conference Report
  • Open Access
2 Citations
6,200 Views
49 Pages

14 January 2022

On behalf of the BraYn Association, we are pleased to present the Abstracts of the Fourth Brainstorming Research Assembly for Young Neuroscientists, which was held from 20–22 October 2021. We congratulate all the presenters on their research wo...

  • Systematic Review
  • Open Access
11 Citations
5,885 Views
10 Pages

Ibrutinib in Refractory or Relapsing Primary Central Nervous System Lymphoma: A Systematic Review

  • Gaurav Nepal,
  • Mahika Khurana,
  • Domenica Herrera Bucheli,
  • Siddhartha Bhandari,
  • Utsav Joshi,
  • Riwaj Bhagat,
  • Jessica Holly Rehrig,
  • Prasun Pudasainee,
  • Yow Ka Shing and
  • Joel Stien
  • + 7 authors

11 January 2022

Primary Central Nervous System Lymphoma (PCNSL) is a rare variant of Non-Hodgkin Lymphoma (NHL) representing 1–2% of all NHL cases. PCNSL is defined as a lymphoma that occurs in the brain, spinal cord, leptomeninges, or eyes. Efforts to treat P...

  • Article
  • Open Access
13 Citations
3,919 Views
9 Pages

11 January 2022

Research in the last decade has focused on assessing financial capacity and incapacity mainly in old age, but new research has turned to address the question of how financial incapacity can be predicted by cognitive factors. The aim of this study was...

  • Editorial
  • Open Access
2,571 Views
1 Page

In the approximately two years since the emergence of COVID-19 (Coronavirus Disease 2019) myriad neurological symptoms have been reported that are seemingly unrelated to each other [...]

  • Review
  • Open Access
21 Citations
17,045 Views
14 Pages

Bremelanotide for Treatment of Female Hypoactive Sexual Desire

  • Amber N. Edinoff,
  • Nicole M. Sanders,
  • Kyle B. Lewis,
  • Tucker L. Apgar,
  • Elyse M. Cornett,
  • Adam M. Kaye and
  • Alan D. Kaye

4 January 2022

Hypoactive sexual desire disorder (HSDD) is a persistent deficiency or absence of sexual fantasies and desire resulting in significant distress or interpersonal difficulty. Women with this disorder may display a lack of motivation for sexual activity...

  • Review
  • Open Access
25 Citations
19,817 Views
13 Pages

Antipsychotic Use in Pregnancy: Patient Mental Health Challenges, Teratogenicity, Pregnancy Complications, and Postnatal Risks

  • Amber N. Edinoff,
  • Niroshan Sathivadivel,
  • Shawn E. McNeil,
  • Austin I. Ly,
  • Jaeyeon Kweon,
  • Neil Kelkar,
  • Elyse M. Cornett,
  • Adam M. Kaye and
  • Alan D. Kaye

3 January 2022

Pregnant women constitute a vulnerable population, with 25.3% of pregnant women classified as suffering from a psychiatric disorder. Since childbearing age typically aligns with the onset of mental health disorders, it is of utmost importance to cons...

  • Review
  • Open Access
24 Citations
7,473 Views
13 Pages

Naltrexone Implant for Opioid Use Disorder

  • Amber N. Edinoff,
  • Catherine A. Nix,
  • Claudia V. Orellana,
  • Samantha M. StPierre,
  • Erin A. Crane,
  • Blaine T. Bulloch,
  • Elyse M. Cornett,
  • Rachel L. Kozinn,
  • Adam M. Kaye and
  • Alan D. Kaye
  • + 1 author

30 December 2021

The continued rise in the availability of illicit opioids and opioid-related deaths in the United States has left physicians, researchers, and lawmakers desperate for solutions to this ongoing epidemic. The research into therapeutic options for the t...

  • Review
  • Open Access
9 Citations
4,641 Views
15 Pages

Guillain-Barré Syndrome in the COVID-19 Pandemic

  • Abdullah Ahmad Tawakul,
  • Amal Waleed Al-Doboke,
  • Shahad Ali Altayyar,
  • Seham Abdulhafith Alsulami,
  • Ahlam Musallam Alfahmi and
  • Raghad Turki Nooh

24 December 2021

There have been several reported cases of severe acute respiratory syndrome (SARS-CoV-2) infection that were associated with an increased incidence of neurological manifestations, including Guillain–Barré syndrome (GBS). This review aims...

  • Article
  • Open Access
12 Citations
3,824 Views
23 Pages

Hypomyelinating Leukodystrophy 7 (HLD7)-Associated Mutation of POLR3A Is Related to Defective Oligodendroglial Cell Differentiation, Which Is Ameliorated by Ibuprofen

  • Sui Sawaguchi,
  • Kenji Tago,
  • Hiroaki Oizumi,
  • Katsuya Ohbuchi,
  • Masahiro Yamamoto,
  • Kazushige Mizoguchi,
  • Yuki Miyamoto and
  • Junji Yamauchi

22 December 2021

Hypomyelinating leukodystrophy 7 (HLD7) is an autosomal recessive oligodendroglial cell-related myelin disease, which is associated with some nucleotide mutations of the RNA polymerase 3 subunit a (polr3a) gene. POLR3A is composed of the catalytic co...

  • Article
  • Open Access
12 Citations
4,602 Views
10 Pages

Co-Designing a New Yoga-Based Mindfulness Intervention for Survivors of Stroke: A Formative Evaluation

  • Tharshanah Thayabaranathan,
  • Maarten A. Immink,
  • Susan Hillier,
  • Rene Stolwyk,
  • Nadine E. Andrew,
  • Philip Stevens,
  • Monique F. Kilkenny,
  • Emma Gee,
  • Leeanne Carey and
  • Dominique A. Cadilhac
  • + 3 authors

21 December 2021

Movement-based mindfulness interventions (MBI) are complex, multi-component interventions for which the design process is rarely reported. For people with stroke, emerging evidence suggests benefits, but mainstream programs are generally unsuitable....

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Neurol. Int. - ISSN 2035-8377