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Neurology International, Volume 14, Issue 1

March 2022 - 24 articles

Cover Story: Pelizaeus–Merzbacher disease is the prototypic hereditary central nervous system hypomyelinating and demyelinating diseases and is now commonly referred to as hypomyelinating leukodystrophy 1 (HLD1). This study for the first time describes abnormal lysosomal localization and accumulation of HLD8-associated mutated proteins of cytoplasmic POLR3B, which is a major subunit of RNA polymerase III. The mutated POLR3B proteins inhibit oligodendroglial cell morphological differentiation with decreased lysosome-related signaling through mTOR. Ibuprofen, which is a NSAID, improves the defects in their differentiation phenotypes and mTOR signaling. These findings may reveal some of the molecular and cellular pathological mechanisms underlying HLD8 and the amelioration. View this paper.
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Articles (24)

  • Review
  • Open Access
16 Citations
6,437 Views
16 Pages

Antipsychotic Polypharmacy-Related Cardiovascular Morbidity and Mortality: A Comprehensive Review

  • Amber N. Edinoff,
  • Emily D. Ellis,
  • Laura M. Nussdorf,
  • Taylor W. Hill,
  • Elyse M. Cornett,
  • Adam M. Kaye and
  • Alan D. Kaye

17 March 2022

Schizophrenia is a psychotic disorder that exists at the more extreme end of a spectrum of diseases, and significantly affects daily functioning. Cardiovascular adverse effects of antipsychotic medications are well known, and include changes in blood...

  • Article
  • Open Access
13 Citations
4,605 Views
10 Pages

Neuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study

  • Fernando Gracia,
  • Deyanira Ramírez,
  • Alexander Parajeles-Vindas,
  • Alejandro Díaz,
  • Amado Díaz de la Fé,
  • Nicia Eunice Ramírez Sánchez,
  • Romy Castro Escobar,
  • Luis Alberto García Valle,
  • Roberto Weiser and
  • Biany Santos
  • + 27 authors

17 March 2022

Here, a study of NMOSD in Central America and the Caribbean with a multinational collaborative, multicentric and descriptive approach involving 25 institutions from 9 countries is presented. Demographics, clinical manifestations, expanded disability...

  • Article
  • Open Access
7 Citations
5,560 Views
13 Pages

Evaluating Therapeutic Equivalence of Generic and Original Levetiracetam in Patients with Epilepsy: A Retrospective Study

  • Jannapas Tharavichitkun,
  • Tinonkorn Yadee,
  • Poomchai Angkaow and
  • Thanarat Suansanae

15 March 2022

The brand interchangeability of antiepileptic drugs (AEDs) is a topic of debate, especially regarding their therapeutic equivalence. This study evaluates the efficacy and tolerability of generic levetiracetam compared to the brand-name equivalent in...

  • Article
  • Open Access
5 Citations
5,677 Views
10 Pages

3 March 2022

Background: Infantile spasms are an age-specific epileptic disorder. They occur in infancy and early childhood. They can be caused by multiple etiologies. Structural abnormalities represent an important cause of infantile spasms. Brain magnetic reson...

  • Article
  • Open Access
4 Citations
3,204 Views
11 Pages

Neurological Screening in Elderly Liver Transplantation Candidates: A Single Center Experience

  • Federica Avorio,
  • Gianvincenzo Sparacia,
  • Giovanna Russelli,
  • Aurelio Seidita,
  • Giuseppe Mamone,
  • Rossella Alduino,
  • Fabio Tuzzolino,
  • Salvatore Gruttadauria,
  • Roberto Miraglia and
  • Matteo Bulati
  • + 1 author

25 February 2022

Background: Cerebral small vessels disease (cSVD) is an age-related disorder and risk factor for stroke and cognitive/motor impairments. Neurological complications (NCs) are among the causes of adverse outcomes in older liver transplant recipients. T...

  • Article
  • Open Access
2 Citations
4,627 Views
33 Pages

Hypomyelinating Leukodystrophy 8 (HLD8)-Associated Mutation of POLR3B Leads to Defective Oligodendroglial Morphological Differentiation Whose Effect Is Reversed by Ibuprofen

  • Sui Sawaguchi,
  • Rimi Suzuki,
  • Hiroaki Oizumi,
  • Katsuya Ohbuchi,
  • Kazushige Mizoguchi,
  • Masahiro Yamamoto,
  • Yuki Miyamoto and
  • Junji Yamauchi

16 February 2022

POLR3B and POLR3A are the major subunits of RNA polymerase III, which synthesizes non-coding RNAs such as tRNAs and rRNAs. Nucleotide mutations of the RNA polymerase 3 subunit b (polr3b) gene are responsible for hypomyelinating leukodystrophy 8 (HLD8...

  • Case Report
  • Open Access
3 Citations
3,671 Views
5 Pages

Clinical and Genetic Analysis of a Patient with CMT4J

  • Leema Reddy Peddareddygari and
  • Raji P. Grewal

10 February 2022

We report the clinical and genetic analysis of a patient with a rare form of an autosomal recessive genetic neuropathy, Charcot Marie Tooth (CMT) disease type 4J. She presented at age 62 years with signs and symptoms consistent with a mild neuropathy...

  • Article
  • Open Access
11 Citations
3,426 Views
8 Pages

Serum CGRP Changes following Ultrasound-Guided Bilateral Greater-Occipital-Nerve Block

  • Abdelrahman Abbas,
  • Ramez Moustafa,
  • Ali Shalash,
  • Mahmoud Haroun,
  • Randa Amin,
  • Sherien Borham,
  • Ahmed Elsadek and
  • Shahinaz Helmy

7 February 2022

Background: Calcitonin-gene-related peptide (CGRP) and CGRP receptors are expressed in trigeminal nerve cells, and treatments targeting CGRP are effective in migraines. For headaches that do not respond to pharmacological treatment, minimally invasiv...

  • Review
  • Open Access
14 Citations
13,039 Views
13 Pages

Oxytocin, a Novel Treatment for Methamphetamine Use Disorder

  • Amber N. Edinoff,
  • Elliot Thompson,
  • Chandler E. Merriman,
  • Mark R. Alvarez,
  • E. Saunders Alpaugh,
  • Elyse M. Cornett,
  • Kevin S. Murnane,
  • Rachel L. Kozinn,
  • Mila Shah-Bruce and
  • Adam M. Kaye
  • + 1 author

30 January 2022

The treatment of substance abuse with oxytocin is a novel approach to a challenging public health issue that continues to contribute to a growing economic cost for societies worldwide. Methamphetamine addiction is one of the leading causes of mortali...

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Neurol. Int. - ISSN 2035-8377