Skip Content
You are currently on the new version of our website. Access the old version .

Neurology International, Volume 13, Issue 4

2021 December - 22 articles

Cover Story: Epileptic encephalopathies often have a genetic etiology. The epileptic activity itself exerts a direct detrimental effect on neurodevelopment, which may add to the cognitive impairment induced by the underlying mutation (“developmental and epileptic encephalopathy”). Most severe epilepsies result from de novo mutations, yet familial clustering can sometimes be observed mostly due to parental transmission with classical mendelian inheritance. This review focuses on inherited mutations affecting ion channels, metabolic signaling, membrane trafficking and exocytosis, cell adhesion, and cell growth and proliferation. Different mutations can provoke common severe epilepsy syndromes or specific phenotypes, whose red flags are illustrated herein and should be carefully sought. View this paper.
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (22)

  • Article
  • Open Access
4 Citations
4,046 Views
11 Pages

Detecting Incident Delirium within Routinely Collected Inpatient Rehabilitation Data: Validation of a Chart-Based Method

  • Marco G. Ceppi,
  • Marlene S. Rauch,
  • Peter S. Sándor,
  • Andreas R. Gantenbein,
  • Shyam Krishnakumar,
  • Monika Albert and
  • Christoph R. Meier

9 December 2021

Background: Delirium is a brain condition associated with poor outcomes in rehabilitation. It is therefore important to assess delirium incidence in rehabilitation. Purpose: To develop and validate a chart-based method to identify incident delirium e...

  • Case Report
  • Open Access
19 Citations
3,917 Views
6 Pages

Clinical Onset and Multiple Sclerosis Relapse after SARS-CoV-2 Infection

  • Antonia Pignolo,
  • Maria Aprile,
  • Cesare Gagliardo,
  • Giovanni Maurizio Giammanco,
  • Marco D’Amelio,
  • Paolo Aridon,
  • Giuseppe La Tona,
  • Giuseppe Salemi and
  • Paolo Ragonese

6 December 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with several neurological disorders including headache, facial palsy, encephalitis, stroke, demyelinating disorders. The present report will discuss cases of m...

  • Article
  • Open Access
3,876 Views
13 Pages

The QOSMOS Study: Pharmacist-Led Multicentered Observational Study on Quality of Life in Multiple Sclerosis

  • Vera Damuzzo,
  • Laura Agnoletto,
  • Roberta Rampazzo,
  • Francesca Cammalleri,
  • Luca Cancanelli,
  • Marco Chiumente,
  • Stefano Costantino,
  • Silvia Michielan,
  • Federica Milani and
  • Daniele Mengato
  • + 2 authors

3 December 2021

Health-related quality of life is frequently included in patient-reported outcomes aimed at evaluating the effectiveness of disease-modifying drugs for multiple sclerosis, but recent data about Italian patients are missing. A multicenter observationa...

  • Systematic Review
  • Open Access
9 Citations
4,518 Views
12 Pages

1 December 2021

Introduction: The role of transesophageal echocardiography (TEE) in cryptogenic stroke and transient ischemic attack (TIA) with normal transthoracic echocardiography (TTE) remains controversial in the absence of definite guidelines. We aimed to perfo...

  • Article
  • Open Access
1 Citations
3,891 Views
11 Pages

1 December 2021

(1) Background: The goal of this study was to determine the incidence of in-hospital mortality and to investigate its predictors in patients with a primary intracranial hemorrhage (ICH) undergoing endotracheal intubation. (2) Methods: This retrospect...

  • Review
  • Open Access
33 Citations
24,746 Views
19 Pages

Anesthetic Considerations for Patients on Psychotropic Drug Therapies

  • Monica W. Harbell,
  • Catalina Dumitrascu,
  • Layne Bettini,
  • Soojie Yu,
  • Cameron M. Thiele and
  • Veerandra Koyyalamudi

29 November 2021

Psychotropic drugs are used in the treatment of psychiatric and non-psychiatric conditions. Many patients who are on psychotropic medications may present for procedures requiring anesthesia. Psychotropic medications can have dangerous interactions wi...

  • Review
  • Open Access
20 Citations
10,185 Views
18 Pages

Spectrum of Neuroimaging Findings in Post-COVID-19 Vaccination: A Case Series and Review of Literature

  • Shitiz Sriwastava,
  • Ashish K. Shrestha,
  • Syed Hassan Khalid,
  • Mark A. Colantonio,
  • Divine Nwafor and
  • Samiksha Srivastava

19 November 2021

Background and Purpose: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in Wuhan, China in December 2019. Symptoms range from mild flu-like symptoms to more severe presentations, including pneumonia, acute re...

  • Article
  • Open Access
18 Citations
5,707 Views
14 Pages

Stroke Aetiology and Collateral Status in Acute Ischemic Stroke Patients Receiving Reperfusion Therapy—A Meta-Analysis

  • Akansha Sinha,
  • Peter Stanwell,
  • Roy G. Beran,
  • Zeljka Calic,
  • Murray C. Killingsworth and
  • Sonu M. M. Bhaskar

16 November 2021

Background: The interplay between collateral status and stroke aetiology may be crucial in the evaluation and management of acute ischemic stroke (AIS). Our understanding of this relationship and its level of association remains sub-optimal. This stu...

  • Case Report
  • Open Access
1 Citations
3,529 Views
7 Pages

Management of Phantom Limb Pain through Thalamotomy of the Centro-Median Nucleus

  • Ramiro A. Pérez de la Torre,
  • Job J. Rodríguez Hernández,
  • Ali Al-Ramadan and
  • Abeer Gharaibeh

10 November 2021

Background: Phantom limb syndrome is defined as the perception of intense pain or other sensations that are secondary to a neural lesion in a limb that does not exist. It can be treated using pharmacological and surgical interventions. Most medicatio...

  • Review
  • Open Access
219 Citations
58,733 Views
14 Pages

Benzodiazepines: Uses, Dangers, and Clinical Considerations

  • Amber N. Edinoff,
  • Catherine A. Nix,
  • Janice Hollier,
  • Caroline E. Sagrera,
  • Blake M. Delacroix,
  • Tunde Abubakar,
  • Elyse M. Cornett,
  • Adam M. Kaye and
  • Alan D. Kaye

10 November 2021

Benzodiazepines (BZDs) are among one of the most widely prescribed drug classes in the United States. BZDs are a class of psychoactive drugs known for their depressant effect on the central nervous system (CNS). They quickly diffuse through the blood...

  • Review
  • Open Access
84 Citations
30,805 Views
17 Pages

Catatonia: Clinical Overview of the Diagnosis, Treatment, and Clinical Challenges

  • Amber N. Edinoff,
  • Sarah E. Kaufman,
  • Janice W. Hollier,
  • Celina G. Virgen,
  • Christian A. Karam,
  • Garett W. Malone,
  • Elyse M. Cornett,
  • Adam M. Kaye and
  • Alan D. Kaye

8 November 2021

Catatonia is a syndrome that has been associated with several mental illness disorders but that has also presented as a result of other medical conditions. Schizophrenia and other psychiatric disorders such as mania and depression are known to be ass...

  • Review
  • Open Access
18 Citations
5,794 Views
14 Pages

3 November 2021

Epileptic encephalopathies often have a genetic etiology. The epileptic activity itself exerts a direct detrimental effect on neurodevelopment, which may add to the cognitive impairment induced by the underlying mutation (“developmental and epileptic...

  • Article
  • Open Access
7 Citations
4,033 Views
14 Pages

Sox2 Ablation in the Suprachiasmatic Nucleus Perturbs Anxiety- and Depressive-like Behaviors

  • Nicholas A. Boehler,
  • Samuel W. Fung,
  • Sara Hegazi,
  • Arthur H. Cheng and
  • Hai-Ying Mary Cheng

26 October 2021

Mood disorders negatively impact the lives of hundreds of millions of individuals worldwide every year, yet the precise molecular mechanisms by which they manifest remain elusive. Circadian dysregulation is one avenue by which mood disorders are thou...

  • Case Report
  • Open Access
2 Citations
3,689 Views
6 Pages

A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature

  • Roberta Rana,
  • Teresa Perillo,
  • Nicola Santoro,
  • Federica Ortolani,
  • Raffaella Messina,
  • Mariachiara Resta,
  • Ilenia Perrucci,
  • Giuseppe Ingravallo,
  • Gerardo Cazzato and
  • Francesco Signorelli
  • + 2 authors

20 October 2021

Central precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic...

  • Article
  • Open Access
6 Citations
6,131 Views
8 Pages

Hydrocephalus and Cerebrospinal Fluid Analysis Following Severe Traumatic Brain Injury: Evaluation of a Prospective Cohort

  • Hansen Deng,
  • Ezequiel Goldschmidt,
  • Enyinna Nwachuku,
  • John K. Yue,
  • Federico Angriman,
  • Zhishuo Wei,
  • Nitin Agarwal,
  • Ava M. Puccio and
  • David O. Okonkwo

19 October 2021

The development of hydrocephalus after severe traumatic brain injury (TBI) is an under-recognized healthcare phenomenon and can increase morbidity. The current study aims to characterize post-traumatic hydrocephalus (PTH) in a large cohort. Patients...

  • Article
  • Open Access
4 Citations
6,051 Views
10 Pages

Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective Study

  • Vasileios Siokas,
  • Konstantinos Katsiardanis,
  • Athina-Maria Aloizou,
  • Christos Bakirtzis,
  • Ioannis Liampas,
  • Evangelos Koutlas,
  • Jobst Rudolf,
  • Konstantinos Ntinoulis,
  • Jannis Kountouras and
  • Georgia Deretzi
  • + 1 author

11 October 2021

A Backround: Multiple sclerosis (MS) is a complex chronic disease of the central nervous system (CNS). Body mass index (BMI), a component of metabolic syndrome (MetS), is considered among the risk factors for MS. However, its role in MS remains ambig...

  • Case Report
  • Open Access
5,241 Views
7 Pages

9 October 2021

A 32-year-old man presented with complete third nerve palsy. Brain magnetic resonance imaging revealed a possible sporadic oculomotor nerve schwannoma in the left cavernous sinus. Interestingly, the patient’s ptosis was fluctuating and eased immediat...

  • Review
  • Open Access
46 Citations
15,439 Views
13 Pages

1 October 2021

Serotonin-norepinephrine reuptake inhibitors (SNRIs) inhibit the presynaptic neuronal uptake of serotonin and norepinephrine and prolong the effects of the monoamines in the synaptic cleft within the central nervous system, leading to increased posts...

  • Case Report
  • Open Access
8 Citations
4,149 Views
10 Pages

28 September 2021

We present a case of a patient with positive N-methyl-D-aspartate receptor (NMDAR) IgG antibodies in their serum and cerebrospinal fluid (CSF) associated with neuroborreliosis. Clinically, the patient presented with symptoms of confusion, as well as...

  • Article
  • Open Access
2 Citations
3,945 Views
10 Pages

23 September 2021

Within the neuropsychological assessment, clinicians are responsible for ensuring the validity of obtained cognitive data. As such, increased attention is being paid to performance validity in patients with multiple sclerosis (pwMS). Experts have pro...

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Neurol. Int. - ISSN 2035-8377