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Case Report

A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature

1
Department of Pediatric Oncology and Hematology, University “Aldo Moro” of Bari, 70124 Bari, Italy
2
Department of Metabolic Diseases, Clinical Genetics and Diabetology, Giovanni XXIII Children’s Hospital, 70124 Bari, Italy
3
Division of Neurosurgery, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University “Aldo Moro” of Bari, 70124 Bari, Italy
4
Division of Neuroradiology, Department of Basic Medical Sciences, Neurosciences and Sense Organs, University “Aldo Moro” of Bari, 70124 Bari, Italy
5
Department of Emergency and Organ Transplantation—Section of Pathology, University “Aldo Moro” of Bari, 70124 Bari, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Daniele Orsucci
Neurol. Int. 2021, 13(4), 535-540; https://doi.org/10.3390/neurolint13040053
Received: 29 September 2021 / Revised: 11 October 2021 / Accepted: 15 October 2021 / Published: 20 October 2021
(This article belongs to the Special Issue The Neurogenetics of Degenerative Disorders)
Central precocious puberty (CPP) is a condition that causes early gonadotropin-dependent sexual development; CPP is idiopathic in girls in most cases, whereas more than 50% of boys have an identifiable etiology. We conducted a qualitative systematic review following the ENTREQ (enhancing transparency in reporting the synthesis of qualitative research) framework. A search was made in MEDLINE/Pubmed and MeSH Database using the terms “precocious puberty” AND “brain tumor” OR “posterior fossa tumor” OR “cerebellar tumor” OR “infratentorial tumor”, identifying five cases of pediatric patients with infratentorial tumors and CPP and a case of cerebellar ganglioglioma without hypothalamic−pituitary−gonadal axis involvement and/or intracranial hypertension. Our work highlights the importance of a multidisciplinary approach and extensive central nervous system imaging for patients presenting with CPP in order to detect possible tumor association. Moreover, we believe that this manuscript could contribute to stimulate other research because the exact mechanism of CPP in infratentorial brain lesions has not been understood yet. View Full-Text
Keywords: CPP; ganglioglioma; SNC; neuroradiology CPP; ganglioglioma; SNC; neuroradiology
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MDPI and ACS Style

Rana, R.; Perrillo, T.; Santoro, N.; Ortolani, F.; Messina, R.; Resta, M.; Perrucci, I.; Ingravallo, G.; Cazzato, G.; Grassi, M.; Pesce, S.; Signorelli, F. A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature. Neurol. Int. 2021, 13, 535-540. https://doi.org/10.3390/neurolint13040053

AMA Style

Rana R, Perrillo T, Santoro N, Ortolani F, Messina R, Resta M, Perrucci I, Ingravallo G, Cazzato G, Grassi M, Pesce S, Signorelli F. A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature. Neurology International. 2021; 13(4):535-540. https://doi.org/10.3390/neurolint13040053

Chicago/Turabian Style

Rana, Roberta, Teresa Perrillo, Nicola Santoro, Federica Ortolani, Raffaella Messina, Mariachiara Resta, Ilenia Perrucci, Giuseppe Ingravallo, Gerardo Cazzato, Massimo Grassi, Sabino Pesce, and Francesco Signorelli. 2021. "A Rare Case of Posterior Fossa Tumor and Central Precocious Puberty: Case Presentation and Review of the Literature" Neurology International 13, no. 4: 535-540. https://doi.org/10.3390/neurolint13040053

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