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Pharmaceutics, Volume 7, Issue 2

June 2015 - 5 articles

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Articles (5)

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Review

53 Citations

8,645 Views

16 Pages

Endocytosis of Nanomedicines: The Case of Glycopeptide Engineered PLGA Nanoparticles

Antonietta Vilella,
Barbara Ruozi,
Daniela Belletti,
Francesca Pederzoli,
Marianna Galliani,
Valentina Semeghini,
Flavio Forni,
Michele Zoli,
Maria Angela Vandelli and
Giovanni Tosi

Pharmaceutics2015, 7(2), 74-89;https://doi.org/10.3390/pharmaceutics7020074

19 June 2015

The success of nanomedicine as a new strategy for drug delivery and targeting prompted the interest in developing approaches toward basic and clinical neuroscience. Despite enormous advances on brain research, central nervous system (CNS) disorders r...

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Communication

23 Citations

7,476 Views

10 Pages

Effect of the Compaction and the Size of DNA on the Nuclear Transfer Efficiency after Microinjection in Synchronized Cells

Hidetaka Akita,
Dai Kurihara,
Marco Schmeer,
Martin Schleef and
Hideyoshi Harashima

Pharmaceutics2015, 7(2), 64-73;https://doi.org/10.3390/pharmaceutics7020064

9 June 2015

The nuclear transfer process is one of the critical rate-limiting processes in transgene expression. In the present study, we report on the effect of compaction and the size of the DNA molecule on nuclear transfer efficiency by microinjection. A DNA/...

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Article

21 Citations

7,576 Views

21 Pages

Product Development Studies on Sonocrystallized Curcumin for the Treatment of Gastric Cancer

Mohammad Ashif Khan,
Nida Akhtar,
Vijay Sharma and
Kamla Pathak

Pharmaceutics2015, 7(2), 43-63;https://doi.org/10.3390/pharmaceutics7020043

27 April 2015

Curcumin suffers from the limitation of poor solubility and low dissolution that can lead to limited applications. The investigation was aimed to substantiate the potentiality of melt sonocrystallized gastroretentive tablets of curcumin. Melt sonocry...

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Article

42 Citations

10,358 Views

16 Pages

Liposomal Conjugates for Drug Delivery to the Central Nervous System

Frieder Helm and
Gert Fricker

Pharmaceutics2015, 7(2), 27-42;https://doi.org/10.3390/pharmaceutics7020027

1 April 2015

Treatments of central nervous system (CNS) diseases often fail due to the blood–brain barrier. Circumvention of this obstacle is crucial for any systemic treatment of such diseases to be effective. One approach to transfer drugs into the brain is the...

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Article

15 Citations

9,006 Views

17 Pages

Effects of Mitragynine and a Crude Alkaloid Extract Derived from Mitragyna speciosa Korth. on Permethrin Elimination in Rats

Kachamas Srichana,
Benjamas Janchawee,
Sathaporn Prutipanlai,
Pritsana Raungrut and
Niwat Keawpradub

Pharmaceutics2015, 7(2), 10-26;https://doi.org/10.3390/pharmaceutics7020010

27 March 2015

Detoxification and elimination of permethrin (PM) are mediated by hydrolysis via carboxylesterase (CES). Mitragyna speciosa (kratom) contains mitragynine (MG) and other bioactive alkaloids. Since PM and MG have the same catalytic site and M. speciosa...

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