Next Article in Journal
Investigating In Vitro and Ex Vivo Properties of Artemether/Lumefantrine Double-Fixed Dose Combination Lipid Matrix Tablets Prepared by Hot Fusion
Next Article in Special Issue
Aberrant Neurogliovascular Unit Dynamics in Cerebral Small Vessel Disease: A Rheological Clue to Vascular Parkinsonism
Previous Article in Journal
Lipophilic Polyamines as Promising Components of Liposomal Gene Delivery Systems
Previous Article in Special Issue
Miniaturization and Automation of a Human In Vitro Blood–Brain Barrier Model for the High-Throughput Screening of Compounds in the Early Stage of Drug Discovery
 
 
Article

Detection of Microplastic in Human Placenta and Meconium in a Clinical Setting

1
Clinic of Obstetrics, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität und Humboldt-Universität zu Berlin, Augustenburgerplatz 1, 13507 Berlin, Germany
2
Division of Experimental Obstetrics, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität und Humboldt-Universität zu Berlin, Augustenburgerplatz 1, 13507 Berlin, Germany
3
Environment Agency Austria (Umweltbundesamt GmbH), 1090 Vienna, Austria
4
Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria
*
Author to whom correspondence should be addressed.
Shared senior authorship.
Academic Editors: Winfried Neuhaus, Gert Fricker and Mária A. Deli
Pharmaceutics 2021, 13(7), 921; https://doi.org/10.3390/pharmaceutics13070921
Received: 12 April 2021 / Revised: 14 June 2021 / Accepted: 17 June 2021 / Published: 22 June 2021
(This article belongs to the Special Issue Biological Barriers in Health and Disease)
Environmental pollution with microplastics (MPs) is a major and worldwide concern. Involuntary exposure to MPs by ingestion or inhalation is unavoidable. The effects on human health are still under debate, while in animals, cellular MP translocation and subsequent deleterious effects were shown. First reports indicate a potential intrauterine exposure with MPs, yet readouts are prone to contamination. Method: To establish a thorough protocol for the detection of MPs in human placenta and fetal meconium in a real-life clinical setting, a pilot study was set up to screen for MPs > 50 µm in placental tissue and meconium sampled during two cesarean sections for breech deliveries. After chemical digestion of non-plastic material, Fourier-transform infrared (FTIR) microspectroscopy was used to analyze the presence of 10 common types of microplastic in placenta and stool samples. Results: Human placenta and meconium samples were screened positive for polyethylene, polypropylene, polystyrene, and polyurethane, of which only the latter one was also detected as airborne fallout in the operating room—thus representing potential contamination. Conclusion: We found MPs > 50 µm in placenta and meconium acquired from cesarean delivery. Critical evaluation of potential contamination sources is pivotal and may guide future clinical studies to improve the correct detection of MPs in organ tissue. Studies investigating nano-sized plastics in human tissue are warranted. View Full-Text
Keywords: microplastics; placenta; fetus; pregnancy; polystyrene microplastics; placenta; fetus; pregnancy; polystyrene
Show Figures

Figure 1

MDPI and ACS Style

Braun, T.; Ehrlich, L.; Henrich, W.; Koeppel, S.; Lomako, I.; Schwabl, P.; Liebmann, B. Detection of Microplastic in Human Placenta and Meconium in a Clinical Setting. Pharmaceutics 2021, 13, 921. https://doi.org/10.3390/pharmaceutics13070921

AMA Style

Braun T, Ehrlich L, Henrich W, Koeppel S, Lomako I, Schwabl P, Liebmann B. Detection of Microplastic in Human Placenta and Meconium in a Clinical Setting. Pharmaceutics. 2021; 13(7):921. https://doi.org/10.3390/pharmaceutics13070921

Chicago/Turabian Style

Braun, Thorsten, Loreen Ehrlich, Wolfgang Henrich, Sebastian Koeppel, Ievgeniia Lomako, Philipp Schwabl, and Bettina Liebmann. 2021. "Detection of Microplastic in Human Placenta and Meconium in a Clinical Setting" Pharmaceutics 13, no. 7: 921. https://doi.org/10.3390/pharmaceutics13070921

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop