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Review

Nucleocytoplasmic Shuttling of Influenza A Virus Proteins

by
Jing Li
1,†,
Meng Yu
1,2,†,
Weinan Zheng
1 and
Wenjun Liu
1,2,*
1
Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Viruses 2015, 7(5), 2668-2682; https://doi.org/10.3390/v7052668
Submission received: 24 December 2014 / Accepted: 20 May 2015 / Published: 22 May 2015
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Abstract

Influenza viruses transcribe and replicate their genomes in the nuclei of infected host cells. The viral ribonucleoprotein (vRNP) complex of influenza virus is the essential genetic unit of the virus. The viral proteins play important roles in multiple processes, including virus structural maintenance, mediating nucleocytoplasmic shuttling of the vRNP complex, virus particle assembly, and budding. Nucleocytoplasmic shuttling of viral proteins occurs throughout the entire virus life cycle. This review mainly focuses on matrix protein (M1), nucleoprotein (NP), nonstructural protein (NS1), and nuclear export protein (NEP), summarizing the mechanisms of their nucleocytoplasmic shuttling and the regulation of virus replication through their phosphorylation to further understand the regulation of nucleocytoplasmic shuttling in host adaptation of the viruses.
Keywords: influenza A virus; nucleocytoplasmic shuttling; virus replication influenza A virus; nucleocytoplasmic shuttling; virus replication

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MDPI and ACS Style

Li, J.; Yu, M.; Zheng, W.; Liu, W. Nucleocytoplasmic Shuttling of Influenza A Virus Proteins. Viruses 2015, 7, 2668-2682. https://doi.org/10.3390/v7052668

AMA Style

Li J, Yu M, Zheng W, Liu W. Nucleocytoplasmic Shuttling of Influenza A Virus Proteins. Viruses. 2015; 7(5):2668-2682. https://doi.org/10.3390/v7052668

Chicago/Turabian Style

Li, Jing, Meng Yu, Weinan Zheng, and Wenjun Liu. 2015. "Nucleocytoplasmic Shuttling of Influenza A Virus Proteins" Viruses 7, no. 5: 2668-2682. https://doi.org/10.3390/v7052668

APA Style

Li, J., Yu, M., Zheng, W., & Liu, W. (2015). Nucleocytoplasmic Shuttling of Influenza A Virus Proteins. Viruses, 7(5), 2668-2682. https://doi.org/10.3390/v7052668

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