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Viruses 2015, 7(5), 2668-2682;

Nucleocytoplasmic Shuttling of Influenza A Virus Proteins

Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
University of Chinese Academy of Sciences, Beijing 100049, China
Author to whom correspondence should be addressed.
Academic Editor: Alexander Ploss
Received: 24 December 2014 / Accepted: 20 May 2015 / Published: 22 May 2015
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Influenza viruses transcribe and replicate their genomes in the nuclei of infected host cells. The viral ribonucleoprotein (vRNP) complex of influenza virus is the essential genetic unit of the virus. The viral proteins play important roles in multiple processes, including virus structural maintenance, mediating nucleocytoplasmic shuttling of the vRNP complex, virus particle assembly, and budding. Nucleocytoplasmic shuttling of viral proteins occurs throughout the entire virus life cycle. This review mainly focuses on matrix protein (M1), nucleoprotein (NP), nonstructural protein (NS1), and nuclear export protein (NEP), summarizing the mechanisms of their nucleocytoplasmic shuttling and the regulation of virus replication through their phosphorylation to further understand the regulation of nucleocytoplasmic shuttling in host adaptation of the viruses. View Full-Text
Keywords: influenza A virus; nucleocytoplasmic shuttling; virus replication influenza A virus; nucleocytoplasmic shuttling; virus replication

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Li, J.; Yu, M.; Zheng, W.; Liu, W. Nucleocytoplasmic Shuttling of Influenza A Virus Proteins. Viruses 2015, 7, 2668-2682.

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