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Viruses, Volume 16, Issue 4

April 2024 - 170 articles

Cover Story: Understanding why viral spillover, i.e., the transmission of a pathogen from a reservoir to recipient host species, leads to disease emergence in novel species in some instances while not in others is essential to prevent future disease outbreaks. We explored the case of deformed wing virus (DWV), which spills over from honeybees to bumblebees, though with apparently low impact. To identify potential barriers to disease emergence in bumblebees, we tracked the spread of DWV throughout a recipient host’s body after experimental viral exposure. Though DWV rapidly spread throughout the body of a honeybee, in bumblebees, the virus was restricted to the gut following oral transmission and low shedding was observed. This suggests that the gut represents a barrier to DWV spread in bumblebees, reducing DWV's impact on them and limiting disease emergence. View this paper
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Articles (170)

  • Article
  • Open Access
5 Citations
3,274 Views
12 Pages

SARS-CoV-2 Omicron BA.1 Variant Infection of Human Colon Epithelial Cells

  • Avan Antia,
  • David M. Alvarado,
  • Qiru Zeng,
  • Luis A. Casorla-Perez,
  • Deanna L. Davis,
  • Naomi M. Sonnek,
  • Matthew A. Ciorba and
  • Siyuan Ding

19 April 2024

The Omicron variant of SARS-CoV-2, characterized by multiple subvariants including BA.1, XBB.1.5, EG.5, and JN.1, became the predominant strain in early 2022. Studies indicate that Omicron replicates less efficiently in lung tissue compared to the an...

  • Article
  • Open Access
3 Citations
3,711 Views
13 Pages

DMSO and Its Role in Differentiation Impact Efficacy of Human Adenovirus (HAdV) Infection in HepaRG Cells

  • Katharina Hofmann,
  • Samuel Hofmann,
  • Franziska Weigl,
  • Julia Mai and
  • Sabrina Schreiner

19 April 2024

Differentiated HepaRG cells are popular in vitro cell models for hepatotoxicity studies. Their differentiation is usually supported by the addition of dimethyl sulfoxide (DMSO), an amphipathic solvent widely used in biomedicine, for example, in poten...

  • Article
  • Open Access
3 Citations
2,417 Views
15 Pages

Favipiravir Treatment Prolongs Survival in a Lethal BALB/c Mouse Model of Ebinur Lake Virus Infection

  • Jingke Geng,
  • Nanjie Ren,
  • Cihan Yang,
  • Fei Wang,
  • Doudou Huang,
  • Sergio Rodriguez,
  • Zhiming Yuan and
  • Han Xia

18 April 2024

Orthobunyavirus is the largest and most diverse genus in the family Peribunyaviridae. Orthobunyaviruses are widely distributed globally and pose threats to human and animal health. Ebinur Lake virus (EBIV) is a newly classified Orthobunyavirus detect...

  • Article
  • Open Access
3 Citations
3,516 Views
20 Pages

Identification of Bacteria and Viruses Associated with Patients with Acute Febrile Illness in Khon Kaen Province, Thailand

  • Rungrat Jitvaropas,
  • Vorthon Sawaswong,
  • Yong Poovorawan,
  • Nutthanun Auysawasdi,
  • Viboonsak Vuthitanachot,
  • Sirima Wongwairot,
  • Wuttikon Rodkvamtook,
  • Erica Lindroth,
  • Sunchai Payungporn and
  • Piyada Linsuwanon

18 April 2024

The majority of cases of undifferentiated acute febrile illness (AFI) in the tropics have an undefined etiology. In Thailand, AFI accounts for two-thirds of illnesses reported to the Ministry of Public Health. To characterize the bacterial and viral...

  • Review
  • Open Access
7 Citations
3,726 Views
17 Pages

18 April 2024

Treating brain disease is challenging, and the Zika virus (ZIKV) presents a unique obstacle due to its neuroinvasive nature. In this review, we discuss the immunopathogenesis of ZIKV and explore how the virus interacts with the body’s immune re...

  • Article
  • Open Access
5 Citations
3,197 Views
12 Pages

Dismantling Barriers to Hepatitis B and Delta Screening, Prevention, and Linkage to Care among the PWUD Community in Philadelphia

  • Beatrice Zovich,
  • Catherine Freeland,
  • Holly Moore,
  • Kara Sapp,
  • Anousha Qureshi,
  • Rachel Holbert,
  • Jason Zambrano,
  • Daljinder Bhangoo,
  • Chari Cohen and
  • Richard W. Hass
  • + 1 author

18 April 2024

The prevalence of hepatitis B and delta viruses (HBV/HDV) among people who use drugs (PWUD) remains largely unknown. In the context of one Philadelphia-based harm reduction organization (HRO), this study aimed to assess HBV/HDV prevalence and facilit...

  • Article
  • Open Access
6 Citations
3,348 Views
13 Pages

Trends in and Risk Factors for Drug Resistance in Mycobacterium tuberculosis in HIV-Infected Patients

  • Xiaoqin Le,
  • Xueqin Qian,
  • Li Liu,
  • Jianjun Sun,
  • Wei Song,
  • Tangkai Qi,
  • Zhenyan Wang,
  • Yang Tang,
  • Shuibao Xu and
  • Junyang Yang
  • + 5 authors

18 April 2024

Trends in and risk factors for drug resistance in Mycobacterium tuberculosis (M. tuberculosis) in human immunodeficiency virus (HIV)-infected patients with active tuberculosis were analyzed. The clinical data of M. tuberculosis and HIV-coinfected pat...

  • Article
  • Open Access
2 Citations
2,554 Views
17 Pages

Detection and Characterization of Influenza A Virus Endemic Circulation in Suckling and Nursery Pigs Originating from Vaccinated Farms in the Same Production System

  • Alessandra Silva Dias,
  • Amy L. Vincent Baker,
  • Rodney B. Baker,
  • Jianqiang Zhang,
  • Michael A. Zeller,
  • Pravina Kitikoon and
  • Phillip C. Gauger

18 April 2024

Inactivated influenza A virus (IAV) vaccines help reduce clinical disease in suckling piglets, although endemic infections still exist. The objective of this study was to evaluate the detection of IAV in suckling and nursery piglets from IAV-vaccinat...

  • Article
  • Open Access
17 Citations
6,062 Views
10 Pages

Spatial Transmission Characteristics of the Bluetongue Virus Serotype 3 Epidemic in The Netherlands, 2023

  • Gert-Jan Boender,
  • Thomas J. Hagenaars,
  • Melle Holwerda,
  • Marcel A. H. Spierenburg,
  • Piet A. van Rijn,
  • Arco N. van der Spek and
  • Armin R. W. Elbers

17 April 2024

A devastating bluetongue (BT) epidemic caused by bluetongue virus serotype 3 (BTV-3) has spread throughout most of the Netherlands within two months since the first infection was officially confirmed in the beginning of September 2023. The epidemic c...

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Viruses - ISSN 1999-4915