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Viruses, Volume 16, Issue 3

March 2024 - 168 articles

Cover Story: Restriction factors constitute an important first-line defense of the host cell against viral infection. We demonstrate that cellular expression levels of the chromatin-remodeling factor SPOC1 (alternatively termed PHF13) critically determine the outcome of human cytomegalovirus infection. Our results suggest that SPOC1 exerts a multilayered defense strategy that increases the chromatin compaction of viral genes resulting in strongly diminished viral transcription, DNA replication and release. Furthermore, we provide evidence that this regulatory mechanism is supported by the polycomb repressive complex 2 and that association of these proteins with viral DNA might directly interfere with late viral transcription. View this paper
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Articles (168)

  • Article
  • Open Access
1 Citations
2,724 Views
13 Pages

A Cocktail of Lipid Nanoparticle-mRNA Vaccines Broaden Immune Responses against β-Coronaviruses in a Murine Model

  • Yi Zhang,
  • Jialu Zhang,
  • Dongmei Li,
  • Qunying Mao,
  • Xiuling Li,
  • Zhenglun Liang and
  • Qian He

21 March 2024

Severe acute respiratory syndrome (SARS)-coronavirus (CoV), Middle Eastern respiratory syndrome (MERS)-CoV, and SARS-CoV-2 have seriously threatened human life in the 21st century. Emerging and re-emerging β-coronaviruses after the coronavirus d...

  • Review
  • Open Access
5 Citations
3,747 Views
32 Pages

The Adaptive Immune Response against Bunyavirales

  • Reem Alatrash and
  • Bobby Brooke Herrera

21 March 2024

The Bunyavirales order includes at least fourteen families with diverse but related viruses, which are transmitted to vertebrate hosts by arthropod or rodent vectors. These viruses are responsible for an increasing number of outbreaks worldwide and r...

  • Article
  • Open Access
12 Citations
4,036 Views
12 Pages

Wastewater-Based Epidemiology for Viral Surveillance from an Endemic Perspective: Evidence and Challenges

  • Marco Verani,
  • Alessandra Pagani,
  • Ileana Federigi,
  • Giulia Lauretani,
  • Nebiyu Tariku Atomsa,
  • Virginia Rossi,
  • Luca Viviani and
  • Annalaura Carducci

20 March 2024

Wastewater-based epidemiology (WBE) is currently used to monitor not only the spread of the viral SARS-CoV-2 pandemic but also that of other viruses in endemic conditions, particularly in the absence of syndromic surveillance. The continuous monitori...

  • Article
  • Open Access
5 Citations
2,187 Views
15 Pages

The Effect of Global Spread, Epidemiology, and Control Strategies on the Evolution of the GI-19 Lineage of Infectious Bronchitis Virus

  • Giovanni Franzo,
  • Giulia Faustini,
  • Claudia Maria Tucciarone,
  • Francesca Poletto,
  • Francesca Tonellato,
  • Mattia Cecchinato and
  • Matteo Legnardi

20 March 2024

The GI-19 lineage of infectious bronchitis virus (IBV) has emerged as one of the most impactful, particularly in the “Old World”. Originating in China several decades ago, it has consistently spread and evolved, often forming independent...

  • Brief Report
  • Open Access
22 Citations
3,095 Views
9 Pages

Parvovirus B19 Outbreak in Israel: Retrospective Molecular Analysis from 2010 to 2023

  • Orna Mor,
  • Marina Wax,
  • Shoshana-Shani Arami,
  • Maya Yitzhaki,
  • Or Kriger,
  • Oran Erster and
  • Neta S. Zuckerman

20 March 2024

This study presents an analysis of the epidemiological trends of parvovirus B19 (B19V) in Israel from 2010 to 2023, with particular emphasis on the outbreak in 2023. The analysis utilized molecular diagnostic data from individual patients obtained at...

  • Article
  • Open Access
6 Citations
2,381 Views
13 Pages

20 March 2024

The emergence of new virus variants, including the Omicron variant (B.1.1.529) of SARS-CoV-2, can lead to reduced vaccine effectiveness (VE) and the need for new vaccines or vaccine doses if the extent of immune evasion is severe. Neutralizing antibo...

  • Review
  • Open Access
37 Citations
12,658 Views
26 Pages

20 March 2024

Healthcare faces a major problem with the increased emergence of antimicrobial resistance due to over-prescribing antibiotics. Bacteriophages may provide a solution to the treatment of bacterial infections given their specificity. Enzymes such as end...

  • Communication
  • Open Access
5 Citations
4,148 Views
9 Pages

Epidemiological and Genetic Characterization of Coxsackievirus A6-Associated Hand, Foot, and Mouth Disease in Gwangju, South Korea, in 2022

  • Ji-Eun Lee,
  • Min-Ji Kim,
  • Mi-Hyeon Lim,
  • Sue-Ji Han,
  • Jin-Yeong Kim,
  • Soo-Hoo Kim,
  • Yi-Duen Ha,
  • Gyung-Li Gang,
  • Yoon-Seok Chung and
  • Jung-Mi Seo

20 March 2024

Coxsackievirus A6 (CV-A6) has emerged as the predominant causative agent of hand, foot, and mouth disease (HFMD) in young children. Since the declaration of coronavirus disease 2019 (COVID-19) as a global pandemic, the incidence of infectious disease...

  • Article
  • Open Access
1 Citations
2,435 Views
15 Pages

Predicting Natural Evolution in the RBD Region of the Spike Glycoprotein of SARS-CoV-2 by Machine Learning

  • Yiheng Liu,
  • Zitong He,
  • Liyiyang Jia,
  • Yiwei Xue,
  • Yuxuan Du,
  • Huiwen Tan,
  • Xianzhi Zhang,
  • Yu Ji,
  • Yigang Tong and
  • Haijun Xu
  • + 1 author

20 March 2024

Machine learning (ML) is a key focus in predicting protein mutations and aiding directed evolution. Research on potential virus variants is crucial for vaccine development. In this study, the machine learning software PyPEF was employed to conduct mu...

  • Article
  • Open Access
3,243 Views
10 Pages

A New Inovirus from the Human Blood Encodes Proteins with Nuclear Subcellular Localization

  • Nikolay Popgeorgiev,
  • Mart Krupovic,
  • Julien Hiblot,
  • Laura Fancello,
  • Sonia Monteil-Bouchard and
  • Christelle Desnues

20 March 2024

Viruses infecting bacteria (bacteriophages) represent the most abundant viral particles in the human body. They participate in the control of the human-associated bacterial communities and play an important role in the dissemination of virulence gene...

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Viruses - ISSN 1999-4915Creative Common CC BY license