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Viruses, Volume 15, Issue 2

February 2023 - 329 articles

Cover Story: Membrane fusion events during enveloped virus entry have been associated with an innate antiviral response, but the mechanisms are unclear. In this study, we use lipoplexes containing purified reovirus p14 fusion protein as a model of exogenous fusion and a cell line expressing p14 protein as a model of endogenous fusion, which is illustrated here. We show that the cellular response to membrane fusion in both models depends on calcium, IRF3, and IFN. However, exogenous p14 is detected by RIG-I-like RNA sensors, whereas fusion by endogenous p14 requires both RIG-I and STING to trigger an IFN response. The source of nucleic acid that is sensed appears to be cellular in origin. Future studies will investigate the source of endogenous nucleic acids recognized following membrane fusion events. View this paper
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Articles (329)

  • Communication
  • Open Access
28 Citations
10,464 Views
23 Pages

Phage Therapy in Germany—Update 2023

  • Christian Willy,
  • Joachim J. Bugert,
  • Annika Y. Classen,
  • Li Deng,
  • Anja Düchting,
  • Justus Gross,
  • Jens A. Hammerl,
  • Imke H. E. Korf,
  • Christian Kühn and
  • Simone Lieberknecht-Jouy
  • + 10 authors

20 February 2023

Bacteriophage therapy holds promise in addressing the antibiotic-resistance crisis, globally and in Germany. Here, we provide an overview of the current situation (2023) of applied phage therapy and supporting research in Germany. The authors, an int...

  • Article
  • Open Access
9 Citations
3,322 Views
24 Pages

A Novel Mathematical Model That Predicts the Protection Time of SARS-CoV-2 Antibodies

  • Zhaobin Xu,
  • Dongqing Wei,
  • Hongmei Zhang and
  • Jacques Demongeot

20 February 2023

Infectious diseases such as SARS-CoV-2 pose a considerable threat to public health. Constructing a reliable mathematical model helps us quantitatively explain the kinetic characteristics of antibody-virus interactions. A novel and robust model is dev...

  • Review
  • Open Access
22 Citations
6,584 Views
15 Pages

Bioinformatic Tools for NGS-Based Metagenomics to Improve the Clinical Diagnosis of Emerging, Re-Emerging and New Viruses

  • Marta Ibañez-Lligoña,
  • Sergi Colomer-Castell,
  • Alejandra González-Sánchez,
  • Josep Gregori,
  • Carolina Campos,
  • Damir Garcia-Cehic,
  • Cristina Andrés,
  • Maria Piñana,
  • Tomàs Pumarola and
  • Francisco Rodríguez-Frias
  • + 2 authors

20 February 2023

Epidemics and pandemics have occurred since the beginning of time, resulting in millions of deaths. Many such disease outbreaks are caused by viruses. Some viruses, particularly RNA viruses, are characterized by their high genetic variability, and th...

  • Article
  • Open Access
6 Citations
3,599 Views
13 Pages

Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil

  • Mariane Talon de Menezes,
  • Filipe Romero Rebello Moreira,
  • Charles Whittaker,
  • Franciele Martins Santos,
  • Daniel Costa Queiroz,
  • Victor Geddes,
  • Paula Luize Camargos Fonseca,
  • Jaqueline Góes de Jesus,
  • Franciane Mendes-Oliveira and
  • Valquíria Reis-Souza
  • + 11 authors

20 February 2023

Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2...

  • Brief Report
  • Open Access
3 Citations
2,452 Views
11 Pages

Epitope Coverage of Anti-SARS-CoV-2 Nucleocapsid IgA and IgG Antibodies Correlates with Protection against Re-Infection by New Variants in Subsequent Waves of the COVID-19 Pandemic

  • Michelle O. Mullins,
  • Muneerah Smith,
  • Hazel Maboreke,
  • Andrew J. M. Nel,
  • Ntobeko A. B. Ntusi,
  • Wendy A. Burgers and
  • Jonathan M. Blackburn

20 February 2023

The COVID-19 pandemic continues to affect individuals across the globe, with some individuals experiencing more severe disease than others. The relatively high frequency of re-infections and breakthrough infections observed with SARS-CoV-2 highlights...

  • Article
  • Open Access
10 Citations
4,395 Views
16 Pages

Whole-Genome Analysis of Influenza A(H3N2) and B/Victoria Viruses Detected in Myanmar during the COVID-19 Pandemic in 2021

  • Irina Chon,
  • Reiko Saito,
  • Yadanar Kyaw,
  • Moe Myat Aye,
  • Swe Setk,
  • Wint Wint Phyu,
  • Keita Wagatsuma,
  • Jiaming Li,
  • Yuyang Sun and
  • Teruhime Otoguro
  • + 6 authors

20 February 2023

An influenza circulation was observed in Myanmar between October and November in 2021. Patients with symptoms of influenza-like illness were screened using rapid diagnostic test (RDT) kits, and 147/414 (35.5%) upper respiratory tract specimens presen...

  • Communication
  • Open Access
7 Citations
2,951 Views
11 Pages

Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the COVID-19 Pandemic in Hong Kong and Korea

  • Yun Young Go,
  • Maura Carrai,
  • Yan Ru Choi,
  • Christopher J. Brackman,
  • Karina W. S. Tam,
  • Pierra Y. T. Law,
  • Fiona Woodhouse,
  • Jane Gray,
  • Ji Hun Kim and
  • Joohyung Park
  • + 8 authors

20 February 2023

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide since its emergence in 2019. Knowing the potential capacity of the virus to adapt to other species, the serological surveillance of SARS-CoV-2 infe...

  • Article
  • Open Access
7 Citations
3,064 Views
9 Pages

20 February 2023

The current outbreak of coronavirus disease 2019 (COVID-19) has prompted the necessity of efficient treatment strategies. The COVID-19 pandemic was caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Main protease (Mpro), also...

  • Article
  • Open Access
12 Citations
5,210 Views
21 Pages

20 February 2023

Cyanophages exert important top-down controls on their cyanobacteria hosts; however, concurrent analysis of both phage and host populations is needed to better assess phage–host interaction models. We analyzed picocyanobacteria Prochlorococcus...

  • Article
  • Open Access
9 Citations
3,103 Views
18 Pages

High Prevalence of Alternative Diagnoses in Children and Adolescents with Suspected Long COVID—A Single Center Cohort Study

  • Sarah C. Goretzki,
  • Maire Brasseler,
  • Burcin Dogan,
  • Tom Hühne,
  • Daniel Bernard,
  • Anne Schönecker,
  • Mathis Steindor,
  • Andrea Gangfuß,
  • Adela Della Marina and
  • Ursula Felderhoff-Müser
  • + 2 authors

20 February 2023

Background: Long COVID (LC) is a diagnosis that requires exclusion of alternative somatic and mental diseases. The aim of this study was to examine the prevalence of differential diagnoses in suspected pediatric LC patients and assess whether adult L...

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Viruses - ISSN 1999-4915Creative Common CC BY license