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Viruses, Volume 15, Issue 11

November 2023 - 144 articles

Cover Story: Influenza A virus (IAV) causes severe respiratory infections and substantial global morbidity and mortality. Innate immunity, cell death, and inflammation are key in driving severe disease in response to IAV. ZBP1 is an innate immune sensor for IAV infection that triggers NLRP3 inflammasome activation and formation of a PANoptosome complex. Activation of the PANoptosome leads to inflammatory cell death, PANoptosis. However, the role of specific pore-forming molecules downstream of the PANoptosome and potential redundancies between them remain unclear. In this issue, Malireddi et al. show that IAV-induced lytic cell death, PANoptosis, activates MLKL but is not dependent on MLKL. These findings suggest that functional redundancies in pore-forming molecules drive IAV-induced PANoptosis. View this paper
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Articles (144)

  • Article
  • Open Access
6 Citations
2,902 Views
19 Pages

15 November 2023

The Varroa destructor mite is a devastating parasite of honey bees; however the negative effects of varroa parasitism are exacerbated by its role as an efficient vector of the honey bee pathogen, Deformed wing virus (DWV). While no direct treatment f...

  • Article
  • Open Access
10 Citations
2,695 Views
12 Pages

High Seroprevalence of IgG Antibodies to Multiple Arboviruses in People Living with HIV (PLWHIV) in Madagascar

  • Fetra Angelot Rakotomalala,
  • Julie Bouillin,
  • Santatriniaina Dauphin Randriarimanana,
  • Guillaume Thaurignac,
  • Luca Maharavo,
  • Mihaja Raberahona,
  • Lucien Razafindrakoto,
  • Jasmina Rasoanarivo,
  • Mala Rakoto-Andrianarivelo and
  • Danielle Aurore Doll Rakoto
  • + 7 authors

15 November 2023

To estimate the prevalence of IgG antibodies against six arboviruses in people living with HIV-1 (PLWHIV) in Madagascar, we tested samples collected between January 2018 and June 2021. We used a Luminex-based serological assay to detect IgG antibodie...

  • Article
  • Open Access
2 Citations
2,292 Views
16 Pages

The Circulating miRNA Profile of Chronic Hepatitis D and B Patients Is Comparable but Differs from That of Individuals with HBeAg-Negative HBV Infection

  • Daniela Cavallone,
  • Eric David B. Ornos,
  • Gabriele Ricco,
  • Filippo Oliveri,
  • Barbara Coco,
  • Piero Colombatto,
  • Laura De Rosa,
  • Leslie Michelle M. Dalmacio,
  • Ferruccio Bonino and
  • Maurizia Rossana Brunetto

15 November 2023

miRNAs circulating in whole serum and HBsAg-particles are differentially expressed in chronic hepatitis B (CHB) and HBeAg-negative-HBV infection (ENI); their profiles are unknown in chronic hepatitis D (CHD). Serum- and HBsAg-associated miRNAs were a...

  • Article
  • Open Access
3 Citations
2,496 Views
14 Pages

Effects of US7 and UL56 on Cell-to-Cell Spread of Human Herpes Simplex Virus 1

  • Jun Wang,
  • Ke Wu,
  • Longquan Ni,
  • Chenxuan Li,
  • Ruoyan Peng,
  • Yi Li,
  • Zhaojun Fan,
  • Feifei Yin,
  • Fei Deng and
  • Shu Shen
  • + 1 author

14 November 2023

Human herpes simplex virus (HSV), a double-stranded DNA virus belonging to the Herpesviridae family and alpha herpesvirus subfamily, is one of the most epidemic pathogens in the population. Cell-to-cell spread is a special intercellular transmission...

  • Article
  • Open Access
3 Citations
2,673 Views
13 Pages

Integrase Defective Lentiviral Vector Promoter Impacts Transgene Expression in Target Cells and Magnitude of Vector-Induced Immune Responses

  • Sneha Mahesh,
  • Jenny Li,
  • Tatianna Travieso,
  • Danai Psaradelli,
  • Donatella Negri,
  • Mary Klotman,
  • Andrea Cara and
  • Maria Blasi

14 November 2023

Integrase defective lentiviral vectors (IDLVs) are a promising vaccine delivery platform given their ability to induce high magnitude and durable antigen-specific immune responses. IDLVs based on the simian immunodeficiency virus (SIV) are significan...

  • Opinion
  • Open Access
9 Citations
3,067 Views
7 Pages

14 November 2023

In the early stages of drug discovery, researchers develop assays that are compatible with high throughput screening (HTS) and structure activity relationship (SAR) measurements. These assays are designed to evaluate the effectiveness of new and know...

  • Review
  • Open Access
15 Citations
4,072 Views
25 Pages

14 November 2023

Human papillomaviruses (HPVs) represent a diverse group of DNA viruses that infect epithelial cells of mucosal and cutaneous tissues, leading to a wide spectrum of clinical outcomes. Among various HPVs, alpha (α) and beta (β) types have ga...

  • Correction
  • Open Access
1 Citations
1,312 Views
2 Pages

13 November 2023

Ryan L [...]

  • Article
  • Open Access
2 Citations
3,832 Views
13 Pages

Identification of Host Factors for Rift Valley Fever Phlebovirus

  • Velmurugan Balaraman,
  • Sabarish V. Indran,
  • Yonghai Li,
  • David A. Meekins,
  • Laxmi U. M. R. Jakkula,
  • Heidi Liu,
  • Micheal P. Hays,
  • Jayme A. Souza-Neto,
  • Natasha N. Gaudreault and
  • Philip R. Hardwidge
  • + 3 authors

13 November 2023

Rift Valley fever phlebovirus (RVFV) is a zoonotic pathogen that causes Rift Valley fever (RVF) in livestock and humans. Currently, there is no licensed human vaccine or antiviral drug to control RVF. Although multiple species of animals and humans a...

  • Article
  • Open Access
4 Citations
2,253 Views
13 Pages

Longitudinal Analysis of Antibody Response Following SARS-CoV-2 Infection Depending on Disease Severity: A Prospective Cohort Study

  • Christina Zirou,
  • Sentiljana Gumeni,
  • Ioannis Bellos,
  • Ioannis Ntanasis-Stathopoulos,
  • Aimilia D. Sklirou,
  • Tina Bagratuni,
  • Eleni Korompoki,
  • Filia Apostolakou,
  • Ioannis Papassotiriou and
  • Ioannis P. Trougakos
  • + 1 author

13 November 2023

Objective: Severe coronavirus disease 19 (COVID-19) is characterized by a dysregulated inflammatory response, with humoral immunity playing a central role in the disease course. The objective of this study was to assess the immune response and the ef...

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Viruses - ISSN 1999-4915