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Volume 14
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10.3390/v14081724
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Brief Report

The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients

by
Christine Kottaridi
1,*,
Panagiota Resta
2,3,
Danai Leventakou
4,
Katerina Gioti
2,
Ioannis Zygouras
1,
Alina-Roxani Gouloumi
4,
Georgios Sakagiannis
5,
Khalid J. Alzahrani
6,
Maria S. Venetikou
2,
Fragkiski Anthouli-Anagnostopoulou
2 and
Apostolos Beloukas
2,3,*
1
Department of Genetics, Development and Molecular Biology, School of Biology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
2
Department of Biomedical Sciences, University of West Attica, 122 43 Athens, Greece
3
National AIDS Reference Centre of Southern Greece, Department of Public Health Policy, University of West Attica, 115 21 Athens, Greece
4
2nd Department of Pathology, University Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, 124 62 Athens, Greece
5
ENT Consultant, 401 General Army Hospital, 115 25 Athens, Greece
6
Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Viruses 2022, 14(8), 1724; https://doi.org/10.3390/v14081724
Submission received: 13 July 2022 / Revised: 2 August 2022 / Accepted: 2 August 2022 / Published: 4 August 2022
(This article belongs to the Special Issue State-of-the-Art Virus Research in Greece)
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Abstract

Recent trends have shown a dramatic rise in the incidence of oropharyngeal squamous cell carcinoma strongly associated with high-risk human papillomavirus (HPV) of type 16. The genetic variability of HPV16 has been extensively studied in cervical cancer but there are very limited published data concerning the genetic variations of this HPV type in oropharyngeal cancer. In the present study, the genetic variations of HPV16 E6 gene sequences originated from a small cohort of Greek patients diagnosed with oropharyngeal cancer were assessed. The vast majority of the sequences clustered within the European variant branch. The T350G variation was found to be the predominant one. This finding may indicate the need for further studies that could explain the possible impact of this variant in the pathomechanisms of oropharyngeal cancer.
Keywords: Human Papillomavirus; HPV; type 16; genetic variation; head and neck cancer Human Papillomavirus; HPV; type 16; genetic variation; head and neck cancer

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MDPI and ACS Style

Kottaridi, C.; Resta, P.; Leventakou, D.; Gioti, K.; Zygouras, I.; Gouloumi, A.-R.; Sakagiannis, G.; Alzahrani, K.J.; Venetikou, M.S.; Anthouli-Anagnostopoulou, F.; et al. The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients. Viruses 2022, 14, 1724. https://doi.org/10.3390/v14081724

AMA Style

Kottaridi C, Resta P, Leventakou D, Gioti K, Zygouras I, Gouloumi A-R, Sakagiannis G, Alzahrani KJ, Venetikou MS, Anthouli-Anagnostopoulou F, et al. The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients. Viruses. 2022; 14(8):1724. https://doi.org/10.3390/v14081724

Chicago/Turabian Style

Kottaridi, Christine, Panagiota Resta, Danai Leventakou, Katerina Gioti, Ioannis Zygouras, Alina-Roxani Gouloumi, Georgios Sakagiannis, Khalid J. Alzahrani, Maria S. Venetikou, Fragkiski Anthouli-Anagnostopoulou, and et al. 2022. "The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients" Viruses 14, no. 8: 1724. https://doi.org/10.3390/v14081724

APA Style

Kottaridi, C., Resta, P., Leventakou, D., Gioti, K., Zygouras, I., Gouloumi, A.-R., Sakagiannis, G., Alzahrani, K. J., Venetikou, M. S., Anthouli-Anagnostopoulou, F., & Beloukas, A. (2022). The T350G Variation of Human Papillomavirus 16 E6 Gene Prevails in Oropharyngeal Cancer from a Small Cohort of Greek Patients. Viruses, 14(8), 1724. https://doi.org/10.3390/v14081724

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