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Role of Transportin-SR2 in HIV-1 Nuclear Import

Laboratory for Molecular Virology and Gene Therapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, 3000 Leuven, Flanders, Belgium
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Academic Editor: Francesca Di Nunzio
Viruses 2021, 13(5), 829; https://doi.org/10.3390/v13050829
Received: 29 March 2021 / Revised: 29 April 2021 / Accepted: 2 May 2021 / Published: 4 May 2021
(This article belongs to the Special Issue Cell-Host Interplay for Viral Nuclear Import)
The HIV replication cycle depends on the interaction of viral proteins with proteins of the host. Unraveling host–pathogen interactions during the infection is of great importance for understanding the pathogenesis and the development of antiviral therapies. To date HIV uncoating and nuclear import are the most debated steps of the HIV-1 replication cycle. Despite numerous studies during past decades, there is still much controversy with respect to the identity and the role of viral and host factors involved in these processes. In this review, we provide a comprehensive overview on the role of transportin-SR2 as a host cell factor during active nuclear transport. View Full-Text
Keywords: HIV-1; nuclear import; integrase; capsid; transportin-SR2; TRN-SR2; TNPO3; CPSF6 HIV-1; nuclear import; integrase; capsid; transportin-SR2; TRN-SR2; TNPO3; CPSF6
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MDPI and ACS Style

Tabasi, M.; Nombela, I.; Janssens, J.; Lahousse, A.P.; Christ, F.; Debyser, Z. Role of Transportin-SR2 in HIV-1 Nuclear Import. Viruses 2021, 13, 829. https://doi.org/10.3390/v13050829

AMA Style

Tabasi M, Nombela I, Janssens J, Lahousse AP, Christ F, Debyser Z. Role of Transportin-SR2 in HIV-1 Nuclear Import. Viruses. 2021; 13(5):829. https://doi.org/10.3390/v13050829

Chicago/Turabian Style

Tabasi, Maryam; Nombela, Ivan; Janssens, Julie; Lahousse, Adrien P.; Christ, Frauke; Debyser, Zeger. 2021. "Role of Transportin-SR2 in HIV-1 Nuclear Import" Viruses 13, no. 5: 829. https://doi.org/10.3390/v13050829

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