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Viruses, Volume 13, Issue 12

December 2021 - 219 articles

Cover Story: The archaeal caudovirus HF2 lytically infects Halorubrum coriense. Virus and host were isolated from a saltern crystallizer on the shore of Corio Bay, Australia. The viral genome (77,672 bp, dsDNA) has a compact and modular gene organization similar to many bacterial viruses. The functions of most genes are unknown. A series of intergenic repeat (IR) sequences were discovered that were conjectured to contain viral promoters, and in the current study, this was experimentally confirmed. Some IRs were active in both orientations. Apart from promoter motifs, IRs probably also contain binding sites for regulatory proteins. Viral transcripts were examined by reverse-transcriptase PCR (RT-PCR), which revealed transcripts (both sense and antisense) ranging from 1.1 kp to 35.8 kb. The results indicate a complex regulatory network in this and other members of the Haloferacalesvirus genus. View this paper
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Articles (219)

  • Review
  • Open Access
4 Citations
6,105 Views
13 Pages

18 December 2021

Deaths from herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) are rare. A major exception is perinatally acquired HSV-1 or HSV-2 infection where the neonatal death rate is substantial. Fatal HSV infection also occurs occasio...

  • Article
  • Open Access
13 Citations
3,914 Views
15 Pages

Prediction of SARS-CoV-2 Variant Lineages Using the S1-Encoding Region Sequence Obtained by PacBio Single-Molecule Real-Time Sequencing

  • Sébastien Lhomme,
  • Justine Latour,
  • Nicolas Jeanne,
  • Pauline Trémeaux,
  • Noémie Ranger,
  • Marion Migueres,
  • Gérald Salin,
  • Cécile Donnadieu and
  • Jacques Izopet

18 December 2021

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the causal agent of the COVID-19 pandemic that emerged in late 2019. The outbreak of variants with mutations in the region encoding the spike protein S1 sub-unit that can make them...

  • Review
  • Open Access
12 Citations
3,887 Views
17 Pages

Immune Dysregulation Is Associated with Neurodevelopment and Neurocognitive Performance in HIV Pediatric Populations—A Scoping Review

  • Monray E. Williams,
  • Anicia Janse Van Rensburg,
  • Du Toit Loots,
  • Petrus J. W. Naudé and
  • Shayne Mason

18 December 2021

HIV-1 is known for its complex interaction with the dysregulated immune system and is responsible for the development of neurocognitive deficits and neurodevelopmental delays in pediatric HIV populations. Considering that HIV-1-induced immune dysregu...

  • Article
  • Open Access
2 Citations
3,640 Views
16 Pages

Influence of Ribavirin on Mumps Virus Population Diversity

  • Mirna Jurković,
  • Anamarija Slović,
  • Dubravko Forčić,
  • Jelena Ivančić-Jelečki,
  • Tanja Košutić-Gulija and
  • Maja Jagušić

17 December 2021

Frequent mumps outbreaks in vaccinated populations and the occurrence of neurological complications (e.g., aseptic meningitis or encephalitis) in patients with mumps indicate the need for the development of more efficient vaccines as well as specific...

  • Article
  • Open Access
21 Citations
5,406 Views
18 Pages

Differential Effect of SARS-CoV-2 Spike Glycoprotein 1 on Human Bronchial and Alveolar Lung Mucosa Models: Implications for Pathogenicity

  • Mizanur Rahman,
  • Martin Irmler,
  • Sandeep Keshavan,
  • Micol Introna,
  • Johannes Beckers,
  • Lena Palmberg,
  • Gunnar Johanson,
  • Koustav Ganguly and
  • Swapna Upadhyay

17 December 2021

Background: The SARS-CoV-2 spike protein mediates attachment of the virus to the host cell receptor and fusion between the virus and the cell membrane. The S1 subunit of the spike glycoprotein (S1 protein) contains the angiotensin converting enzyme 2...

  • Article
  • Open Access
8 Citations
3,943 Views
21 Pages

Dynamics of the Enteric Virome in a Swine Herd Affected by Non-PCV2/PRRSV Postweaning Wasting Syndrome

  • Alba Folgueiras-González,
  • Robin van den Braak,
  • Martin Deijs,
  • Wikke Kuller,
  • Steven Sietsma,
  • Valentijn Thuring,
  • Lia van der Hoek and
  • Ad de Groof

17 December 2021

A commercial pig farm with no history of porcine circovirus 2 (PCV2) or porcine reproductive and respiratory syndrome virus (PRRSV) repeatedly reported a significant reduction in body weight gain and wasting symptoms in approximately 20–30% of...

  • Article
  • Open Access
14 Citations
5,240 Views
20 Pages

Genomic Analysis of the First European Bacteriophages with Depolymerase Activity and Biocontrol Efficacy against the Phytopathogen Ralstonia solanacearum

  • Elena G. Biosca,
  • José Francisco Català-Senent,
  • Àngela Figàs-Segura,
  • Edson Bertolini,
  • María M. López and
  • Belén Álvarez

17 December 2021

Ralstonia solanacearum is the causative agent of bacterial wilt, one of the most destructive plant diseases. While chemical control has an environmental impact, biological control strategies can allow sustainable agrosystems. Three lytic bacteriophag...

  • Article
  • Open Access
9 Citations
5,499 Views
15 Pages

Coronavirus RNA Synthesis Takes Place within Membrane-Bound Sites

  • Nicole Doyle,
  • Jennifer Simpson,
  • Philippa C. Hawes and
  • Helena J. Maier

17 December 2021

Infectious bronchitis virus (IBV), a gammacoronavirus, is an economically important virus to the poultry industry, as well as a significant welfare issue for chickens. As for all positive strand RNA viruses, IBV infection causes rearrangements of the...

  • Article
  • Open Access
44 Citations
7,488 Views
8 Pages

Epigallocatechin Gallate (EGCG), a Green Tea Polyphenol, Reduces Coronavirus Replication in a Mouse Model

  • Rackhyun Park,
  • Minsu Jang,
  • Yea-In Park,
  • Yeonjeong Park,
  • Woochul Jung,
  • Jayhyun Park and
  • Junsoo Park

17 December 2021

The COVID-19 pandemic has resulted in a huge number of deaths from 2020 to 2021; however, effective antiviral drugs against SARS-CoV-2 are currently under development. Recent studies have demonstrated that green tea polyphenols, particularly EGCG, in...

  • Article
  • Open Access
12 Citations
6,584 Views
23 Pages

Emergence of a Distinct Picobirnavirus Genotype Circulating in Patients Hospitalized with Acute Respiratory Illness

  • Michael G. Berg,
  • Kenn Forberg,
  • Lester J. Perez,
  • Ka-Cheung Luk,
  • Todd V. Meyer and
  • Gavin A. Cloherty

17 December 2021

Picobirnaviruses (PBV) are found in a wide range of hosts and typically associated with gastrointestinal infections in immunocompromised individuals. Here, a divergent PBV genome was assembled from a patient hospitalized for acute respiratory illness...

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Viruses - ISSN 1999-4915