Viruses, Volume 14, Issue 1
2022 January - 165 articles
Cover Story: Omicron, the most recent SARS-CoV-2 variant of concern, harbors multiple mutations in the spike protein. Initial studies suggest that Omicron substantially reduces the neutralizing capability of antibodies induced from COVID-19 vaccination or previous infection. However, its effect on T cells remains to be determined. This work assesses the effect of Omicron mutations on T cell epitopes known to be targeted in COVID-19-infected or -vaccinated individuals. It is shown that 80% of epitopes within the spike protein and 97% of epitopes outside the spike protein are unaffected by Omicron mutations. Moreover, among the small fraction of epitopes comprising Omicron mutations, the majority are still predicted to be presented to T cells. Thus, T cell responses induced by previous infection or vaccination will likely remain intact and continue to provide protection against severe disease. View this paper. - Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
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