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Open AccessFeature PaperArticle

Influence of Radiation Sterilization on Properties of Biodegradable Lactide/Glycolide/Trimethylene Carbonate and Lactide/Glycolide/ε-caprolactone Porous Scaffolds with Shape Memory Behavior

1
Faculty of Mathematics and Natural Sciences, Jan Dlugosz University in Czestochowa, Armii Krajowej 13/15 Av., Czestochowa 42-218, Poland
2
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Curie-Sklodowska 34 St., Zabrze 41-800, Poland
3
Department of Biomaterials, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al Mickiewicza 30, Kraków 30-059, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Marek M. Kowalczuk
Materials 2016, 9(1), 64; https://doi.org/10.3390/ma9010064
Received: 21 December 2015 / Revised: 7 January 2016 / Accepted: 11 January 2016 / Published: 20 January 2016
(This article belongs to the Special Issue Biodegradable and Bio-Based Polymers)
The aim of the study was the evaluation of gamma irradiation and electron beams for sterilization of porous scaffolds with shape memory behavior obtained from biodegradable terpolymers: poly(l-lactide-co-glycolide-co-trimethylene carbonate) and poly(l-lactide-co-glycolide-co-ɛ-caprolactone). The impact of mentioned sterilization techniques on the structure of the scaffolds before and after the sterilization process using irradiation doses ranged from 10 to 25 kGy has been investigated. Treatment of the samples with gamma irradiation at 15 kGy dose resulted in considerable drop in glass transition temperature (Tg) and number average molecular weight (Mn). For comparison, after irradiation of the samples using an electron beam with the same dose, no significant changes in structure or properties of examined scaffolds have been noticed. Higher doses of irradiation via electron beam caused essential changes of the scaffolds’ pores resulting in partial melting of their surface. Nevertheless, obtained results have revealed that sterilization with electron beam, when compared to gamma irradiation, is a better method because it does not affect significantly the physicochemical properties of the scaffolds. Both used methods of sterilization did not influence the shape memory behavior of the examined materials. View Full-Text
Keywords: biodegradable polymer; gamma sterilization; electron beam sterilization; radiation degradation; scaffold; shape memory biodegradable polymer; gamma sterilization; electron beam sterilization; radiation degradation; scaffold; shape memory
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MDPI and ACS Style

Rychter, P.; Śmigiel-Gac, N.; Pamuła, E.; Smola-Dmochowska, A.; Janeczek, H.; Prochwicz, W.; Dobrzyński, P. Influence of Radiation Sterilization on Properties of Biodegradable Lactide/Glycolide/Trimethylene Carbonate and Lactide/Glycolide/ε-caprolactone Porous Scaffolds with Shape Memory Behavior. Materials 2016, 9, 64.

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