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Current Oncology
Volume 26
Issue 3
10.3747/co.26.4066
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Total Compared with Partial Pancreatectomy for Pancreatic Adenocarcinoma: Assessment of Resection Margin, Readmission Rate, and Survival from the U.S. National Cancer Database

by
M.J. Passeri
1,
E.H. Baker
1,
I.A. Siddiqui
1,
M.A. Templin
2,
J.B. Martinie
1,
D. Vrochides
1 and
D.A. Iannitti
1,*
1
Department of Surgery, Division of Hepatopancreatobiliary Surgery, Carolinas Medical Center, Charlotte, NC, USA
2
Center for Outcomes Research and Evaluation, Carolinas HealthCare System, Charlotte, NC, USA
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2019, 26(3), 346-356; https://doi.org/10.3747/co.26.4066
Submission received: 6 March 2019 / Revised: 6 April 2019 / Accepted: 6 May 2019 / Published: 1 June 2019

Abstract

Introduction: Total pancreatectomy for pancreatic ductal adenocarcinoma has historically been associated with substantial patient morbidity and mortality. Given advancements in perioperative and postoperative care, evaluation of the surgical treatment options for pancreatic adenocarcinoma should consider patient outcomes and long-term survival for total pancreatectomy compared with partial pancreatectomy. Methods: The U.S. National Cancer Database was queried for patients undergoing total pancreatectomy or partial pancreatectomy for pancreatic adenocarcinoma during 1998–2006. Demographics, tumour characteristics, operative outcomes, 30-day mortality, 30-day readmission, additional treatment, and Kaplan–Meier survival curves were compared. Results: The database query returned 807 patients who underwent total pancreatectomy and 5840 who underwent partial pancreatectomy. More patients who underwent total pancreatectomy than a partial pancreatectomy had a margin-negative resection (p < 0.0001). Mortality and readmission rates were similar in the two groups, as was long-term survival on Kaplan–Meier curves (p = 0.377). A statistically significant difference in the rate of surgery only (without additional treatment) was observed for patients in the total pancreatectomy group (p = 0.0003). Conclusions: Although total compared with partial pancreatectomy was associated with a higher rate of margin-negative resection, median survival was not significantly different for patients undergoing either procedure. Patients who underwent total pancreatectomy were significantly less likely to receive adjuvant therapy.
Keywords: pancreatectomy; pancreaticoduodenectomy; pancreatic neoplasms; morbidity; mortality; databases; postoperative care pancreatectomy; pancreaticoduodenectomy; pancreatic neoplasms; morbidity; mortality; databases; postoperative care

Share and Cite

MDPI and ACS Style

Passeri, M.J.; Baker, E.H.; Siddiqui, I.A.; Templin, M.A.; Martinie, J.B.; Vrochides, D.; Iannitti, D.A. Total Compared with Partial Pancreatectomy for Pancreatic Adenocarcinoma: Assessment of Resection Margin, Readmission Rate, and Survival from the U.S. National Cancer Database. Curr. Oncol. 2019, 26, 346-356. https://doi.org/10.3747/co.26.4066

AMA Style

Passeri MJ, Baker EH, Siddiqui IA, Templin MA, Martinie JB, Vrochides D, Iannitti DA. Total Compared with Partial Pancreatectomy for Pancreatic Adenocarcinoma: Assessment of Resection Margin, Readmission Rate, and Survival from the U.S. National Cancer Database. Current Oncology. 2019; 26(3):346-356. https://doi.org/10.3747/co.26.4066

Chicago/Turabian Style

Passeri, M.J., E.H. Baker, I.A. Siddiqui, M.A. Templin, J.B. Martinie, D. Vrochides, and D.A. Iannitti. 2019. "Total Compared with Partial Pancreatectomy for Pancreatic Adenocarcinoma: Assessment of Resection Margin, Readmission Rate, and Survival from the U.S. National Cancer Database" Current Oncology 26, no. 3: 346-356. https://doi.org/10.3747/co.26.4066

APA Style

Passeri, M. J., Baker, E. H., Siddiqui, I. A., Templin, M. A., Martinie, J. B., Vrochides, D., & Iannitti, D. A. (2019). Total Compared with Partial Pancreatectomy for Pancreatic Adenocarcinoma: Assessment of Resection Margin, Readmission Rate, and Survival from the U.S. National Cancer Database. Current Oncology, 26(3), 346-356. https://doi.org/10.3747/co.26.4066

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