2019 June - 33 articles
The use of real-world evidence (rwe) through real-world data (rwd) is becoming increasingly prevalent in health care around the globe. [...]
Call it cannabis, not marijuana or weed [...]
In their report of 10 December 2018, the Canadian Task Force on Preventive Health Care gave a lukewarm endorsement of screening mammography.[...]
Palliative care (pc) has evolved from a field of medicine devoted exclusively to end-of-life care into one that focuses on symptom management and quality of life throughout terminal illness.[...]
It’s a Saturday afternoon in February. A Saturday afternoon spent waiting for a telephone call from a pathologist, a personal friend.[...]
Background: CervixCheck, Manitoba’s cervical cancer screening program, conducted a pilot study to assess whether screening participation could be improved in unscreened women by offering a mailed self-sampling kit for human papillomavirus (HPV) testi...
Introduction: The pan-Canadian Oncology Symptom Triage and Remote Support (costars) team is studying how to improve the quality and consistency of cancer symptom management. Methods: A 1-day invitational meeting was held 24 October 2017 in Ottawa, O...
Background: DICER1 syndrome is an autosomal dominant tumour predisposition syndrome associated with a wide variety of cancerous and noncancerous conditions, including ovarian sex cord–stromal tumours and thyroid conditions, including multinodular goi...
Despite advances in therapeutic approaches and supportive care, cancer remains a significant burden on human health.[...]
Hematopoietic stem-cell transplantation (HSCT) is a medical procedure that consists of infusing stem cells after a short course of chemotherapy or radiotherapy, or both. It can be used in the treatment of various cancers, as well as some benign condi...
Background: In relation to the general Canadian population, Inuit face increased cancer risks and barriers to health services use. In shared decision-making (SDM), health care providers and patients make health care decisions together. Enhanced parti...
Background: In Ontario, an online audit and feedback tool that provides primary care physicians with detailed information about patients who are overdue for cancer screening is underused. In the present study, we aimed to examine the effect of messag...
For nearly a month, Mr. A had struggled to climb the clinic staircase leading to room 307.[...]
Background: Cervical cancer is the 2nd most common malignant tumour in women worldwide. Previous research studies have given little attention to its prognostic factors in the rapidly growing Asian American population. In the present study, we explore...
Background: Colposcopy is a key part of cervical cancer control. As cervical cancer screening and prevention strategies evolve, monitoring colposcopy performance will become even more critical. In the present paper, we describe population-based colpo...
Background: Literature suggests that factors such as rural residence and low socioeconomic status (SES) might contribute to disparities in survival for Canadian cancer patients because of inequities in access to care. However, evidence specific to br...
Background: Commonly used first-line (1L) chemotherapies for patients with advanced squamous-cell lung cancer (SCC) include gemcitabine–platinum (GP), nab-paclitaxel–carboplatin (nabpc), and sb-paclitaxel–carboplatin (sbpc) regimens. However, no head...
Introduction: Patients with metastatic cancer have a decreased life expectancy, and with screening and surveillance for new primary cancers, they run the risk of immediate harm with little chance of any benefit. Choosing Wisely Canada therefore recom...
Background: Clinical trials have demonstrated an increased risk of cardiotoxicity in patients with breast cancer (BCA) receiving trastuzumab-based therapy. Diabetes, dyslipidemia, and obesity are known risk factors for cardiovascular disease. Studies...
Introduction: Cardiovascular disease is the 2nd leading cause of long-term morbidity and mortality in cancer survivors. Cardio-oncology clinics (COCS) have emerged to address the issue; however, there is a paucity of data about the demographics and c...
Introduction: RIntroductionadiation-induced brain necrosis [“radionecrosis” (RN)] is a relatively uncommon but potentially severe adverse effect of stereotactic radiosurgery (SRS) for brain metastasis. Although dose, volume, and hypofractionation hav...
Background and Purpose: Adjuvant whole-breast irradiation after breast-conserving surgery, typically delivered over several weeks, is the traditional standard of care for low-risk breast cancer. More recently, hypofractionated, partial-breast irradia...
Background: Isolated abdominal lymphadenopathy is frequently detected, but often challenging to diagnose. To obtain a tissue diagnosis, percutaneous biopsy (PB) or laparoscopic biopsy (LB) is often undertaken. The safety profiles and diagnostic accur...
Introduction: Total pancreatectomy for pancreatic ductal adenocarcinoma has historically been associated with substantial patient morbidity and mortality. Given advancements in perioperative and postoperative care, evaluation of the surgical treatmen...
Background: We investigated whether preoperative anemia and perioperative blood transfusion (PBT) are associated with overall survival and recurrence-free survival in patients with nonmetastatic colorectal cancer. Methods: From 1 January 2009 to 31 D...
Background: Diagnosis and treatment of renal cell carcinoma (RCC) might be different in Indigenous Canadians than in non-Indigenous Canadians. In this cohort study, we compared RCC presentation and treatments in Indigenous and non-Indigenous Canadian...
Background: Patients with limited-stage (LS) or extensive-stage (ES) small-cell lung cancer (SCLC) are commonly given platinum-based chemotherapy as first-line treatment. Standard chemotherapy for patients with LS SCLC includes a platinum agent such...
Background: Clinical practice guidelines recommend a multidisciplinary approach to cancer care that brings together all relevant disciplines to discuss optimal disease management. However, the literature is characterized by heterogeneous definitions...
Background: Chemoradiation with curative intent is considered the standard of care in patients with locally advanced, stage III non-small-cell lung cancer (NSCLC). However, some patients with stage III (N2 or N3, excluding T4) NSCLC might be eligible...
Although mastectomy is an effective procedure, it can have a negative effect on body image, sense of attractiveness, and sexuality. As opposed to the combination of breast oncologic surgery and plastic surgery, whose primary focus is on replacing los...
Two guidelines about opioid use in chronic pain management were published in 2017: the Canadian Guideline for Opioids for Chronic Non-Cancer Pain and the European Pain Federation position paper on appropriate opioid use in chronic pain management. Th...
Introduction: The number of survivors of breast cancer (bca) in Canada has steadily increased thanks to major advances in cancer care. But the resulting clientele face new challenges related to survivorship. The lack of continuity of care and the sid...
Combination immune checkpoint blockade with concurrent administration of the anti-CTLA4 antibody ipilimumab and the anti–PD-1 antibody nivolumab has demonstrated impressive responses in patients with advanced melanoma and other diseases. That combina...
