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Open AccessArticle

Topical Treatment of Elevated Intraocular Pressure in Patients with Graves’ Orbitopathy

1
Provisus Eye Clinic, 112 Redzinska str., 42-209 Częstochowa, Poland
2
Department of Ophthalmology and Visual Rehabilitation, Central Veterans Hospital, Medical University of Lodz, 113 Zeromskiego str., 90-549 Lodz, Poland
3
Department of Statistics, State University of Applied Science in Konin, 1 Przyjazni str., 65-510 Konin, Poland
4
Saint Family Hospital Medical Center, 19 Wigury str., 90-302 Lodz, Poland
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(24), 9331; https://doi.org/10.3390/ijerph17249331
Received: 14 September 2020 / Revised: 11 November 2020 / Accepted: 9 December 2020 / Published: 13 December 2020
(This article belongs to the Section Global Health)
Purpose: In this study, we evaluated the efficacy of topical hypotensive treatment and/or systemic corticosteroids therapy in patients with elevated intraocular pressure and Graves’ orbitopathy (GO). Methods: We included 172 eyes in 86 individuals with duration of GO ≥ 3 months, intraocular pressure in either eye ≥ 25.0 mmHg, and GO ranked ≥ 3 at least in one eye in modified CAS form. The study subjects were divided into three treatment subgroups: subgroup I was administered latanoprost once a day; subgroup II was administered a combined preparation of brimonidine and timolol BID; subgroup III was the control group, not receiving any topical hypotensive treatment. All the study participants received systemic treatment, intravenous corticosteroid therapy at the same dose, according to the European Group of Graves’ Orbitopathy (EUGOGO) guideline. Results: On the final visit, the mean IOP value was significantly lower in all treatment subgroups compared to the initial values. In both subgroups receiving topical treatment, the IOP reduction was higher than in the control group receiving systemic corticosteroids only. However, the latanoprost eye drops decreased intraocular pressure more effectively than drops containing brimonidine and timolol. Conclusion: Topical ocular hypotensive treatment is effective in reducing intraocular pressure in GO and decreases intraocular pressure more effectively than systemic corticosteroid therapy alone. View Full-Text
Keywords: Graves’ orbitopathy; exophthalmos; intraocular pressure; topical medications Graves’ orbitopathy; exophthalmos; intraocular pressure; topical medications
MDPI and ACS Style

Gumińska, M.; Goś, R.; Śmigielski, J.; Nowak, M.S. Topical Treatment of Elevated Intraocular Pressure in Patients with Graves’ Orbitopathy. Int. J. Environ. Res. Public Health 2020, 17, 9331. https://doi.org/10.3390/ijerph17249331

AMA Style

Gumińska M, Goś R, Śmigielski J, Nowak MS. Topical Treatment of Elevated Intraocular Pressure in Patients with Graves’ Orbitopathy. International Journal of Environmental Research and Public Health. 2020; 17(24):9331. https://doi.org/10.3390/ijerph17249331

Chicago/Turabian Style

Gumińska, Magdalena; Goś, Roman; Śmigielski, Janusz; Nowak, Michał S. 2020. "Topical Treatment of Elevated Intraocular Pressure in Patients with Graves’ Orbitopathy" Int. J. Environ. Res. Public Health 17, no. 24: 9331. https://doi.org/10.3390/ijerph17249331

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