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Volume 17
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10.3390/ijerph17165998
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Conference Report

Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020

by
Giuseppina Campisi
1,2,
Rodolfo Mauceri
1,2,3,*,
Francesco Bertoldo
2,4,
Giordana Bettini
2,5,
Matteo Biasotto
6,
Giuseppe Colella
7,
Ugo Consolo
8,
Olga Di Fede
1,2,
Gianfranco Favia
9,
Vittorio Fusco
2,10,
Mario Gabriele
11,
Antonio Lo Casto
1,2,
Lorenzo Lo Muzio
12,
Antonia Marcianò
3,
Marco Mascitti
13,
Marco Meleti
14,
Michele D. Mignogna
15,
Giacomo Oteri
3,
Vera Panzarella
1,2,
Umberto Romeo
16,
Andrea Santarelli
13,
Paolo Vescovi
2,14,
Claudio Marchetti
2,17 and
Alberto Bedogni
2,5
1
Department of Surgical, Oncological, and Oral Sciences, University of Palermo, 90127 Palermo, Italy
2
IAC-ONJ (Italian Allied Committee on ONJ), Temporary Chair at University of Palermo, 90100 Piazza Marina, Italy
3
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98124 Messina, Italy
4
Department of Medicine, University of Verona, 37134 Verona, Italy
5
Regional Center for Prevention, Diagnosis and Treatment of Medication and Radiation-Related Bone Diseases of the Head and Neck, University of Padova, 35128 Padova, Italy
6
Department of Medical, Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy
7
Department of Medical, Surgical and Dental Speciality, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
8
Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, 41125 Modena, Italy
9
Department of Interdisciplinary Medicine, University of Bari Aldo Moro, 70124 Bari, Italy
10
Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy
11
Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56126 Pisa, Italy
12
Department of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy
13
Department of Clinical Specialistic and Dental Sciences, Marche Polytechnic University, 60126 Ancona, Italy
14
Department of Medicine and Surgery, University of Parma, 43125 Parma, Italy
15
Department of Neuroscience, Reproductive and Odontostomatological Sciences, University of Naples Federico II, 80131 Napoli, Italy
16
Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Roma, Italy
17
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40125 Bologna, Italy
*
Author to whom correspondence should be addressed.
Int. J. Environ. Res. Public Health 2020, 17(16), 5998; https://doi.org/10.3390/ijerph17165998
Received: 7 July 2020 / Revised: 10 August 2020 / Accepted: 11 August 2020 / Published: 18 August 2020
(This article belongs to the Special Issue Dental Public Health: Issues, Challenges and Opportunities)
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Abstract

The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majority of dentists and oral surgeons involved in MRONJ prevention (primary and secondary). The present paper reports the update of the conclusions from the Consensus Conference—held at the Symposium of the Italian Society of Oral Pathology and Medicine (SIPMO) (20 October 2018, Ancona, Italy)—after the newest recommendations (2020) on MRONJ were published by two scientific societies (Italian Societies of Maxillofacial Surgery and Oral Pathology and Medicine, SICMF and SIPMO), written on the inputs of the experts of the Italian Allied Committee on ONJ (IAC-ONJ). The conference focused on the topic of MRONJ, and in particular on the common practices at risk of inappropriateness in MRONJ diagnosis and therapy, as well as on MRONJ prevention and the dental management of patients at risk of MRONJ. It is a matter of cancer and osteometabolic patients that are at risk since being exposed to several drugs with antiresorptive (i.e., bisphosphonates and denosumab) or, more recently, antiangiogenic activities. At the same time, the Conference traced for dentists and oral surgeons some easy applicable indications and procedures to reduce MRONJ onset risk and to diagnose it early. Continuous updating on these issues, so important for the patient community, is recommended. View Full-Text
Keywords: MRONJ; prevention models; dentistry; oral surgery; bisphosphonates; denosumab; antiresorptive drugs; antiangiogenic agents; cancer; osteoporosis MRONJ; prevention models; dentistry; oral surgery; bisphosphonates; denosumab; antiresorptive drugs; antiangiogenic agents; cancer; osteoporosis
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MDPI and ACS Style

Campisi, G.; Mauceri, R.; Bertoldo, F.; Bettini, G.; Biasotto, M.; Colella, G.; Consolo, U.; Di Fede, O.; Favia, G.; Fusco, V.; Gabriele, M.; Lo Casto, A.; Lo Muzio, L.; Marcianò, A.; Mascitti, M.; Meleti, M.; Mignogna, M.D.; Oteri, G.; Panzarella, V.; Romeo, U.; Santarelli, A.; Vescovi, P.; Marchetti, C.; Bedogni, A. Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020. Int. J. Environ. Res. Public Health 2020, 17, 5998. https://doi.org/10.3390/ijerph17165998

AMA Style

Campisi G, Mauceri R, Bertoldo F, Bettini G, Biasotto M, Colella G, Consolo U, Di Fede O, Favia G, Fusco V, Gabriele M, Lo Casto A, Lo Muzio L, Marcianò A, Mascitti M, Meleti M, Mignogna MD, Oteri G, Panzarella V, Romeo U, Santarelli A, Vescovi P, Marchetti C, Bedogni A. Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020. International Journal of Environmental Research and Public Health. 2020; 17(16):5998. https://doi.org/10.3390/ijerph17165998

Chicago/Turabian Style

Campisi, Giuseppina, Rodolfo Mauceri, Francesco Bertoldo, Giordana Bettini, Matteo Biasotto, Giuseppe Colella, Ugo Consolo, Olga Di Fede, Gianfranco Favia, Vittorio Fusco, Mario Gabriele, Antonio Lo Casto, Lorenzo Lo Muzio, Antonia Marcianò, Marco Mascitti, Marco Meleti, Michele D. Mignogna, Giacomo Oteri, Vera Panzarella, Umberto Romeo, Andrea Santarelli, Paolo Vescovi, Claudio Marchetti, and Alberto Bedogni. 2020. "Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020" International Journal of Environmental Research and Public Health 17, no. 16: 5998. https://doi.org/10.3390/ijerph17165998

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