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MiRNAs and miRNA Polymorphisms Modify Drug Response

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China
Department of Cardiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China
Haikou People’s Hospital and Affiliated Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570311, China
Authors to whom correspondence should be addressed.
Academic Editor: William Chi-shing Cho
Int. J. Environ. Res. Public Health 2016, 13(11), 1096;
Received: 14 September 2016 / Revised: 17 October 2016 / Accepted: 31 October 2016 / Published: 8 November 2016
(This article belongs to the Section Global Health)
Differences in expression of drug response-related genes contribute to inter-individual variation in drugs’ biological effects. MicroRNAs (miRNAs) are small noncoding RNAs emerging as new players in epigenetic regulation of gene expression at post-transcriptional level. MiRNAs regulate the expression of genes involved in drug metabolism, drug transportation, drug targets and downstream signal molecules directly or indirectly. MiRNA polymorphisms, the genetic variations affecting miRNA expression and/or miRNA-mRNA interaction, provide a new insight into the understanding of inter-individual difference in drug response. Here, we provide an overview of the recent progress in miRNAs mediated regulation of biotransformation enzymes, drug transporters, and nuclear receptors. We also describe the implications of miRNA polymorphisms in cancer chemotherapy response. View Full-Text
Keywords: microRNA; drug response; miRNA polymorphisms; prognosis microRNA; drug response; miRNA polymorphisms; prognosis
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Li, M.-P.; Hu, Y.-D.; Hu, X.-L.; Zhang, Y.-J.; Yang, Y.-L.; Jiang, C.; Tang, J.; Chen, X.-P. MiRNAs and miRNA Polymorphisms Modify Drug Response. Int. J. Environ. Res. Public Health 2016, 13, 1096.

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