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Marine Indole Alkaloids

Institute of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55128 Mainz, Germany
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Academic Editor: Valeria Costantino
Mar. Drugs 2015, 13(8), 4814-4914; https://doi.org/10.3390/md13084814
Received: 30 June 2015 / Revised: 17 July 2015 / Accepted: 24 July 2015 / Published: 6 August 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed. View Full-Text
Keywords: indoles; alkaloids; marine natural products; bisindoles; nitrogen heterocycles; carbolines; prenylated indoles; diketopiperazines indoles; alkaloids; marine natural products; bisindoles; nitrogen heterocycles; carbolines; prenylated indoles; diketopiperazines
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Netz, N.; Opatz, T. Marine Indole Alkaloids. Mar. Drugs 2015, 13, 4814-4914.

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