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Cadmium-Containing Carbonic Anhydrase CDCA1 in Marine Diatom Thalassiosira weissflogii

Institute of Biostructures and Bioimaging—National Research Council (CNR), Via Mezzocannone 16, I-80134 Naples, Italy
Author to whom correspondence should be addressed.
Academic Editor: Véronique Martin-Jézéquel
Mar. Drugs 2015, 13(4), 1688-1697;
Received: 20 January 2015 / Revised: 12 March 2015 / Accepted: 17 March 2015 / Published: 25 March 2015
(This article belongs to the Special Issue Metabolites in Diatoms)
PDF [796 KB, uploaded 27 March 2015]


The Carbon Concentration Mechanism (CCM) allows phytoplakton species to accumulate the dissolved inorganic carbon (DIC) necessary for an efficient photosynthesis even under carbon dioxide limitation. In this mechanism of primary importance for diatoms, a key role is played by carbonic anhydrase (CA) enzymes which catalyze the reversible hydration of CO2, thus taking part in the acquisition of inorganic carbon for photosynthesis. A novel CA, named CDCA1, has been recently discovered in the marine diatom Thalassiosira weissflogii. CDCA1 is a cambialistic enzyme since it naturally uses Cd2+ as catalytic metal ion, but if necessary can spontaneously exchange Cd2+ to Zn2+. Here, the biochemical and structural features of CDCA1 enzyme will be presented together with its putative biotechnological applications for the detection of metal ions in seawaters. View Full-Text
Keywords: diatom; Thalassiosira weissflogii; carbonic anhydrase; cadmium; zinc diatom; Thalassiosira weissflogii; carbonic anhydrase; cadmium; zinc

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Alterio, V.; Langella, E.; De Simone, G.; Monti, S.M. Cadmium-Containing Carbonic Anhydrase CDCA1 in Marine Diatom Thalassiosira weissflogii. Mar. Drugs 2015, 13, 1688-1697.

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