Identification and Bioactivity of Compounds from the Fungus Penicillium sp. CYE-87 Isolated from a Marine Tunicate
by
Lamiaa A. Shaala 1,2
and 
Diaa T. A. Youssef 3,*
Lamiaa A. Shaala 1,2 and Diaa T. A. Youssef 3,*
1
Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia
2
Suez Canal University Hospital, Suez Canal University, Ismailia 51522, Egypt
3
Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editor: Johannes F. Imhoff
Mar. Drugs 2015, 13(4), 1698-1709; https://doi.org/10.3390/md13041698
Received: 26 December 2014 / Revised: 13 March 2015 / Accepted: 18 March 2015 / Published: 25 March 2015
(This article belongs to the Special Issue Bioactive Compounds from Marine Fungi)
In the course of our continuous interest in identifying bioactive compounds from marine microbes, we have investigated a tunicate-derived fungus, Penicillium sp. CYE-87. A new compound with the 1,4-diazepane skeleton, terretrione D (2), together with the known compounds, methyl-2-([2-(1H-indol-3-yl)ethyl]carbamoyl)acetate (1), tryptamine (3), indole-3-carbaldehyde (4), 3,6-diisobutylpyrazin-2(1H)-one (5) and terretrione C (6), were isolated from Penicillium sp. CYE-87. The structures of the isolated compounds were established by spectral analysis, including 1D (1H, 13C) and 2D (COSY, multiplicity edited-HSQC and HMBC) NMR and HRESIMS, as well as comparison of their NMR data with those in the literature. The compounds were evaluated for their antimigratory activity against the human breast cancer cell line (MDA-MB-231) and their antiproliferation activity against HeLa cells. Compounds 2 and 6 showed significant antimigratory activity against MDA-MB-231, as well as antifungal activity against C. albicans.
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Keywords:
Penicillium sp.; indole alkaloids; 1,4-diazepane derivatives; terretriones C and D; antimigration; antiproliferation; antimicrobial activity
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MDPI and ACS Style
Shaala, L.A.; Youssef, D.T.A. Identification and Bioactivity of Compounds from the Fungus Penicillium sp. CYE-87 Isolated from a Marine Tunicate. Mar. Drugs 2015, 13, 1698-1709.
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