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Open AccessArticle

Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012

by Yiwen Hu 1,2,†, Jiahui Chen 2,3,†, Guping Hu 1,4,†, Jianchen Yu 1,2, Xun Zhu 2,3, Yongcheng Lin 1,4, Shengping Chen 1,5,* and Jie Yuan 1,2,*
1
Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-sen University), Bureau of Education, Guangzhou 510080, China
2
Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China
3
Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou 510080, China
4
School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China
5
School of Marine Sciences, Sun Yat-sen University, Guangzhou 510006, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Orazio Taglialatela-Scafati
Mar. Drugs 2015, 13(1), 202-221; https://doi.org/10.3390/md13010202
Received: 25 September 2014 / Accepted: 22 December 2014 / Published: 7 January 2015
Every year, hundreds of new compounds are discovered from the metabolites of marine organisms. Finding new and useful compounds is one of the crucial drivers for this field of research. Here we describe the statistics of bioactive compounds discovered from marine organisms from 1985 to 2012. This work is based on our database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products. We performed a comprehensive statistical analysis to understand the characteristics of the novel bioactive compounds and detail temporal trends, chemical structures, species distribution, and research progress. We hope this meta-analysis will provide useful information for research into the bioactivity of marine natural products and drug development. View Full-Text
Keywords: bioactivity; marine natural products; quantitative analysis; novel compounds bioactivity; marine natural products; quantitative analysis; novel compounds
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Hu, Y.; Chen, J.; Hu, G.; Yu, J.; Zhu, X.; Lin, Y.; Chen, S.; Yuan, J. Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012. Mar. Drugs 2015, 13, 202-221.

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