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New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne

1
Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
2
Key Laboratory for Marine Drugs, Department of Pharmacy, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
3
Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2014, 12(7), 4096-4109; https://doi.org/10.3390/md12074096
Received: 23 May 2014 / Revised: 15 June 2014 / Accepted: 19 June 2014 / Published: 8 July 2014
Five new sesterterpenoids, compounds 15, have been isolated from the sponge Hippospongia lachne off Yongxing Island in the South China Sea. The structures of compounds 15 were elucidated through extensive spectroscopic analysis, including HRMS, 1D, and 2D NMR experiments. The stereochemistry, including absolute configurations of these compounds, was determined by spectroscopic, chemical, and computational methods. Compounds 1 and 5 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 5.2 μM and 8.7 μM, respectively, more potent than previously reported hippolides. View Full-Text
Keywords: marine sponge; Hippospongia lachne; sesterterpenoids; absolute configuration; PTP1B marine sponge; Hippospongia lachne; sesterterpenoids; absolute configuration; PTP1B
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Piao, S.-J.; Jiao, W.-H.; Yang, F.; Yi, Y.-H.; Di, Y.-T.; Han, B.-N.; Lin, H.-W. New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne. Mar. Drugs 2014, 12, 4096-4109.

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