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Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice

1
Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Institute of Laboratory Animal Science, CAMS & Comparative Medicine Centre, Peking Union Medical College, Beijing 100021, China
2
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China
3
Department of Medicinal Chemistry, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2014, 12(7), 4086-4095; https://doi.org/10.3390/md12074086
Received: 27 March 2014 / Revised: 11 June 2014 / Accepted: 25 June 2014 / Published: 7 July 2014
Enterovirus 71 is one of the major causative agents of hand, foot and mouth disease in children under six years of age. No vaccine or antiviral therapy is currently available. In this work, we found that the number of B cells was reduced in enterovirus 71-infected mice. Deferoxamine, a marine microbial natural product, compensated for the decreased levels of B cells caused by enterovirus 71 infection. The neutralizing antibody titer was also improved after deferoxamine treatment. Furthermore, deferoxamine relieved symptoms and reduced mortality and muscle damage caused by enterovirus 71 infection. This work suggested that deferoxamine has the potential for further development as a B cell-immunomodulator against enterovirus 71. View Full-Text
Keywords: deferoxamine; enterovirus 71; hand; foot and mouth disease; B cells deferoxamine; enterovirus 71; hand; foot and mouth disease; B cells
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Yang, Y.; Ma, J.; Xiu, J.; Bai, L.; Guan, F.; Zhang, L.; Liu, J.; Zhang, L. Deferoxamine Compensates for Decreases in B Cell Counts and Reduces Mortality in Enterovirus 71-Infected Mice. Mar. Drugs 2014, 12, 4086-4095.

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