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Medicina, Volume 57, Issue 11

2021 November - 150 articles

Cover Story: Peptide-based drug delivery systems have benefits compared to synthetic polymers due to their better biocompatibility, biodegradability, and controlled molecular weight. Peptide-based lysosomes, solid lipid nanoparticles, dendrimers, and micelles can be used via intravenous administration and have the ability to penetrate the blood–brain barrier. An overview of nontoxic drug delivery systems was given, and prospective trends in the development of drug delivery systems were discussed. The use of peptide-based carriers for the delivery of various toxic drugs, mostly anticancer drugs with limiting bioavailability, was highlighted. The platforms are utilized as peptide–drug conjugates, injectable biodegradable particles, and depots for delivering small molecule pharmaceutical substances (500 Da) and therapeutic proteins. View this paper.
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Articles (150)

  • Article
  • Open Access
2 Citations
2,589 Views
7 Pages

Minimally Invasive Approaching in Hip Surgery—An Anatomical Investigation of 20 Specimens

  • Clemens Schopper,
  • Hannes Traxler,
  • Bernhard Schauer,
  • Günter Hipmair and ,
  • Tobias Gotterbarm and
  • Matthias Luger
  • + 1 author+ 0 author

22 November 2021

Background and objectives: Based on the preparation of 20 formalin-fixed anatomical cadavers, the feasibility of the anterior, minimally invasive approach to the hip joint was investigated in each side of the body. The hypothesis of the study was tha...

(This article belongs to the Special Issue Hip and Fragility Fracture Management)
  • Article
  • Open Access
21 Citations
10,295 Views
11 Pages

Hyperbaric Oxygen Therapy with Iloprost Improves Digit Salvage in Severe Frostbite Compared to Iloprost Alone

  • Marie-Anne Magnan,
  • Angèle Gayet-Ageron,
  • Pierre Louge,
  • Frederic Champly and ,
  • Thierry Joffre,
  • Christian Lovis and
  • Rodrigue Pignel
  • + 2 authors+ 0 author

22 November 2021

Background and Objectives: Frostbite is a freezing injury that can lead to amputation. Current treatments include tissue rewarming followed by thrombolytic or vasodilators. Hyperbaric oxygen (HBO) therapy might decrease the rate of amputation by incr...

(This article belongs to the Special Issue Hyperbaric Medicine)
  • Systematic Review
  • Open Access
39 Citations
5,664 Views
12 Pages

Meta-Analysis of Prevalence of Depression in Dental Students during COVID-19 Pandemic

  • Javier Santabárbara,
  • Naiara Ozamiz-Etxebarria,
  • Nahia Idoiaga,
  • Beatriz Olaya and
  • Juan Bueno-Novitol

21 November 2021

Background and Objectives: The COVID-19 pandemic has a negative impact on the mental health of the population in general, and in college students in particular. Dental students have seen their teaching altered and their clinical practice reduced. Thi...

(This article belongs to the Special Issue Dental Care and Oral Health during the COVID-19 Pandemic)
  • Article
  • Open Access
13 Citations
3,123 Views
8 Pages

Parvovirus B19 in Croatia: A Large-Scale Seroprevalence Study

  • Tatjana Vilibic-Cavlek,
  • Irena Tabain,
  • Branko Kolaric,
  • Klara Mihulja and ,
  • Lana Blazevic,
  • Maja Bogdanic,
  • Dan Navolan,
  • Natasa Beader and
  • Anna Mrzljak
  • + 4 authors+ 0 author

21 November 2021

Background and Objectives: Seroepidemiological studies indicate that parvovirus B19 circulates in all areas of the world, although with some differences. The aim of this study is to analyze the seroprevalence of parvovirus B19 in the Croatian populat...

  • Article
  • Open Access
2 Citations
2,595 Views
13 Pages

Changes in the Plasma Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1(APE1/Ref-1) Level during Cancer Surgery: An Observational Study

  • Yumin Jo,
  • Yeojung Kim,
  • Eunhye Park,
  • Yuran Lee and ,
  • Jiyeon Kim,
  • Minwoong Kang,
  • Jaesung Lim,
  • Insang Song,
  • Chaeseong Lim and
  • Byeonghwa Jeon
  • + 5 authors+ 0 author

21 November 2021

Background and Objectives: Propofol-based total intravenous anesthesia (TIVA) is presumed to have more favorable effects on the prognosis of patients with cancer compared with volatile inhaled anesthesia (VIA). We hypothesized that these anesthetics...

  • Systematic Review
  • Open Access
10 Citations
5,734 Views
15 Pages

21 November 2021

Background and Objectives: Meconium aspiration syndrome (MAS) is a condition caused by the aspiration of meconium-stainted amniotic fluid into the lungs, resulting in pulmonary inflammation, neonatal morbidity, and mortality. It is important that the...

(This article belongs to the Section Pediatrics)
  • Article
  • Open Access
11 Citations
4,951 Views
10 Pages

Classification and Morphometric Features of Pterion in Thai Population with Potential Sex Prediction

  • Nongnut Uabundit,
  • Arada Chaiyamoon,
  • Sitthichai Iamsaard,
  • Laphatrada Yurasakpong and ,
  • Chanin Nantasenamat,
  • Athikhun Suwannakhan and
  • Nichapa Phunchago
  • + 2 authors+ 0 author

21 November 2021

Background and Objectives: The landmark for neurosurgical approaches to access brain lesion is the pterion. The aim of the present study is to classify and examine the prevalence of all types of pterion variations and perform morphometric measurement...

(This article belongs to the Special Issue Topographic Anatomy of the Human Body)
  • Review
  • Open Access
12 Citations
5,555 Views
9 Pages

Fetal Surveillance in Pregnancies with Myasthenia Gravis

  • Brîndușa Ana Cimpoca-Raptis,
  • Anca Marina Ciobanu,
  • Nicolae Gica,
  • Gheorghe Peltecu and ,
  • Dan Mitrea and
  • Anca Maria Panaitescu
  • + 1 author+ 0 author

20 November 2021

Myasthenia gravis (MG) is an autoimmune condition, that commonly impacts adult women of reproductive age. Myasthenia gravis in pregnancy is rare, but the incidence is higher in different geographical areas. Pregnancies in mothers with MG can have an...

(This article belongs to the Special Issue High-Risk Pregnancy)
  • Review
  • Open Access
16 Citations
13,875 Views
15 Pages

Clinical and Histopathological Features of Scleroderma-like Disorders: An Update

  • Rosario Foti,
  • Rocco De Pasquale,
  • Ylenia Dal Bosco,
  • Elisa Visalli and ,
  • Giorgio Amato,
  • Pietro Gangemi,
  • Riccardo Foti and
  • Alice Ramondetta
  • + 3 authors+ 0 author

20 November 2021

Scleroderma-like disorders include a set of entities involving cutis, subcutis and, sometimes, even muscular tissue, caused by several pathogenetic mechanisms responsible for different clinical–pathological pictures. The absence of antinuclear antibo...

(This article belongs to the Section Hematology and Immunology)
  • Case Report
  • Open Access
1 Citations
3,624 Views
7 Pages

Acute Zonal Occult Outer Retinopathy in a Patient Suffering from Epilepsy: Five-Year Follow-Up

  • Izabella Karska-Basta,
  • Bożena Romanowska-Dixon,
  • Dorota Pojda-Wilczek,
  • Alina Bakunowicz-Łazarczyk and ,
  • Agnieszka Kubicka-Trząska and
  • Karolina Gerba-Górecka
  • + 1 author+ 0 author

20 November 2021

We report an unprecedented case of a young patient with epilepsy coexisting with acute zonal occult outer retinopathy (AZOOR), a rare white dot syndrome of unknown etiology, associated with damage to the large zones of the outer retina. Recently, it...

(This article belongs to the Section Ophthalmology)
  • Article
  • Open Access
2 Citations
2,947 Views
10 Pages

Predictors of Clinical Course and Outcomes of Acute Diverticulitis: The Role of Age and Ethnicity

  • Randa Taher,
  • Yael Kopelman,
  • Abdel-Rauf Zeina,
  • Amir Mari and
  • Fadi Abu Baker

19 November 2021

Background and Objectives: Acute diverticulitis (AD) is the leading and most burdensome complication of colonic diverticulosis. However, risk factors for its development and predictors of its course are still poorly defined. In this regard, the assoc...

(This article belongs to the Section Gastroenterology & Hepatology)
  • Article
  • Open Access
6 Citations
3,465 Views
11 Pages

19 November 2021

Background and Objectives: In recent literature, the routine addition of arthrodesis to decompression for lumbar spinal stenosis (LSS) with concomitant stable low-grade degenerative spondylolisthesis remains controversial. The purpose of this study i...

(This article belongs to the Special Issue Lumbar Spinal Stenosis: Diagnosis and Treatment Options)
  • Article
  • Open Access
14 Citations
3,883 Views
13 Pages

Vitamin D Enhanced the Osteogenic Differentiation of Cell Spheroids Composed of Bone Marrow Stem Cells

  • Hyun-Jin Lee,
  • Young-Min Song,
  • Seunghoon Baek,
  • Yoon-Hee Park and
  • Jun-Beom Park

19 November 2021

Background and Objectives: Vitamin D is a bone modulator widely used in regenerative medicine. This study aimed to analyze the effects of vitamin D on the osteogenic differentiation and mineralization of human mesenchymal stem cells. Materials and Me...

(This article belongs to the Special Issue Recent Advances in Periodontics and Dental Implantology)
  • Review
  • Open Access
10 Citations
3,533 Views
9 Pages

19 November 2021

Immune checkpoint inhibitors (ICIs) are standard treatments for patients with lung cancer. PD-1/PD-L1 or CTLA4 antibodies are chosen as the first-line therapy, contributing to the long-term survival and tolerability. Unlike molecular targeting agents...

(This article belongs to the Section Pulmonology)
  • Article
  • Open Access
6 Citations
3,463 Views
10 Pages

Impact of the COVID-19 Pandemic on Emergency Department Workload and Emergency Care Workers’ Psychosocial Stress in the Outbreak Area

  • In-Hwan Yeo,
  • Yun-Jeong Kim,
  • Jong-Kun Kim,
  • Dong-Eun Lee and ,
  • Jae-Young Choe,
  • Chang-Ho Kim,
  • Jung-Bae Park,
  • Kang-Suk Seo,
  • Sin-Yul Park and
  • Sang-Hun Lee
  • + 7 authors+ 2 authors

19 November 2021

Background and Objectives: Due to the unexpected spread of coronavirus disease 2019 (COVID-19), there was a serious crisis of emergency medical system collapse. Healthcare workers working in the emergency department were faced with psychosocial stres...

(This article belongs to the Special Issue Emergency Medicine and Emergency Room Medical Issues)
  • Review
  • Open Access
24 Citations
8,481 Views
18 Pages

The Lymphatic System in Breast Cancer: Anatomical and Molecular Approaches

  • Gianfranco Natale,
  • Michael E. J. Stouthandel,
  • Tom Van Hoof and
  • Guido Bocci

19 November 2021

Breast cancer is one of the most important causes of premature mortality among women and it is one of the most frequently diagnosed tumours worldwide. For this reason, routine screening for prevention and early diagnosis is important for the quality...

(This article belongs to the Special Issue Vasorum Lymphaticorum: From the Discovery of the Lymphatic System to the New Perspectives in Microsurgical Reconstruction and Patient Rehabilitation)
  • Article
  • Open Access
7 Citations
3,434 Views
11 Pages

A Higher Polygenic Risk Score Is Associated with a Higher Recurrence Rate of Atrial Fibrillation in Direct Current Cardioversion-Treated Patients

  • Simon Vogel,
  • Irina Rudaka,
  • Dmitrijs Rots,
  • Jekaterīna Isakova and ,
  • Oskars Kalējs,
  • Kristīne Vīksne and
  • Linda Gailīte
  • + 2 authors+ 0 author

18 November 2021

Background and Objectives: Recurrence of atrial fibrillation (AF) within six months after sinus rhythm restoration with direct current cardioversion (DCC) is a significant treatment challenge. Currently, the factors influencing outcome are mostly unk...

(This article belongs to the Special Issue Atrial Fibrillation Management)
  • Case Report
  • Open Access
5 Citations
3,421 Views
7 Pages

Nonbacterial Thrombotic Endocarditis Associated with Acute Promyelocytic Leukemia: An Autopsy Case Report

  • Tadayuki Hashimoto,
  • Tatsuya Aoki,
  • Yoshitaka Kawabata,
  • Yoshihiro Owai and ,
  • Yoshikazu Matsuda and
  • Shinobu Tamura
  • + 1 author+ 0 author

18 November 2021

Valve vegetation is one of the most fearful findings for physicians. The first diagnosis that comes to their mind is infective endocarditis (IE), but it can also be noninfective; nonbacterial thrombotic endocarditis (NBTE). NBTE can be even more chal...

(This article belongs to the Section Oncology)
  • Article
  • Open Access
11 Citations
3,414 Views
9 Pages

Characteristics of Patients with Obstructive Sleep Apnea at High Risk for Cardiovascular Disease

  • Izolde Bouloukaki,
  • Michail Fanaridis,
  • Georgios Stathakis,
  • Christina Ermidou and ,
  • Eleftherios Kallergis,
  • Violeta Moniaki,
  • Eleni Mauroudi and
  • Sophia E. Schiza
  • + 3 authors+ 0 author

18 November 2021

Background and Objectives: To evaluate the influence of obstructive sleep apnea (OSA)-related symptoms on prevalent cardiovascular disease (CVD) in a large clinical population of patients. Materials and Methods: A total of 2127 patients (mean age 55...

(This article belongs to the Section Cardiology)
  • Article
  • Open Access
9 Citations
3,223 Views
15 Pages

Longitudinal Motor Functional Outcomes and Magnetic Resonance Imaging Patterns of Muscle Involvement in Upper Limbs in Duchenne Muscular Dystrophy

  • Claudia Brogna,
  • Lara Cristiano,
  • Tommaso Verdolotti,
  • Giulia Norcia and ,
  • Luana Ficociello,
  • Roberta Ruiz,
  • Giorgia Coratti,
  • Lavinia Fanelli,
  • Nicola Forcina and
  • Eugenio Mercuri
  • + 10 authors+ 5 authors

18 November 2021

Background and Objectives: The aim of this study was to evaluate longitudinal changes using both upper limb muscle Magnetic Resonance Imaging (MRI) at shoulder, arm and forearm levels and Performance of upper limb (PUL) in ambulant and non-ambulant D...

(This article belongs to the Section Neurology)
  • Review
  • Open Access
51 Citations
6,399 Views
15 Pages

A Review of Natural Products for Prevention of Acute Kidney Injury

  • Hyun Goo Kang,
  • Hyun Ki Lee,
  • Kyu Bong Cho and
  • Sang Il Park

18 November 2021

Background and Objectives: acute kidney injury (AKI), formerly called acute renal failure (ARF), is commonly defined as an abrupt decline in renal function, clinically manifesting as a reversible acute increase in nitrogen waste products—measured by...

(This article belongs to the Special Issue Acute Kidney Injury: From Basic Findings to New Prevention and Therapy Strategies)
  • Case Report
  • Open Access
9 Citations
6,080 Views
6 Pages

Absence of Wharton’s Jelly at the Abdominal Site of the Umbilical Cord Insertion. Rare Case Report and Review of the Literature

  • Radu Botezatu,
  • Sandra Raduteanu,
  • Anca Marina Ciobanu,
  • Nicolae Gica and ,
  • Gheorghe Peltecu and
  • Anca Maria Panaitescu
  • + 1 author+ 0 author

18 November 2021

Wharton’s jelly is a specialized connective tissue surrounding and protecting umbilical cord vessels. In its absence, the vessels are exposed to the risk of compression or rupture. Because the condition is very rare and there are no available antepar...

(This article belongs to the Special Issue High-Risk Pregnancy)
  • Review
  • Open Access
68 Citations
19,924 Views
14 Pages

Bipolar Disorder and Comorbid Use of Illicit Substances

  • Ulrich W. Preuss,
  • Martin Schaefer,
  • Christoph Born and
  • Heinz Grunze

17 November 2021

Substance use disorders (SUD) are highly prevalent in bipolar disorder (BD) and significantly affect clinical outcomes. Incidence and management of illicit drug use differ from alcohol use disorders, nicotine use of behavioral addictions. It is not y...

(This article belongs to the Special Issue Management of Bipolar Disorder)
  • Review
  • Open Access
10 Citations
4,917 Views
16 Pages

A Portrait of Intratumoral Genomic and Transcriptomic Heterogeneity at Single-Cell Level in Colorectal Cancer

  • Andrea Angius,
  • Antonio Mario Scanu,
  • Caterina Arru,
  • Maria Rosaria Muroni and ,
  • Ciriaco Carru,
  • Alberto Porcu,
  • Paolo Cossu-Rocca and
  • Maria Rosaria De Miglio
  • + 3 authors+ 0 author

17 November 2021

In the study of cancer, omics technologies are supporting the transition from traditional clinical approaches to precision medicine. Intra-tumoral heterogeneity (ITH) is detectable within a single tumor in which cancer cell subpopulations with differ...

(This article belongs to the Special Issue Therapeutic Landscapes in Colorectal Carcinoma)
  • Review
  • Open Access
14 Citations
5,284 Views
12 Pages

Maternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms

  • Francesca Frincu,
  • Andreea Carp-Veliscu,
  • Aida Petca,
  • Dumitru-Cristinel Badiu and ,
  • Elvira Bratila,
  • Monica Cirstoiu and
  • Claudia Mehedintu
  • + 2 authors+ 0 author

17 November 2021

The connection between endometriosis and pregnancy outcomes is trending among the research topics. Until recently, endometriosis and its painful symptomatology were considered to be alleviated by pregnancy. However, these beliefs have shifted, as eme...

(This article belongs to the Special Issue Clinical Manifestations and Treatment of Endometriosis)
  • Review
  • Open Access
27 Citations
10,350 Views
13 Pages

17 November 2021

Background and Objectives: Sugammadex is widely used in anesthesia to reverse rocuronium-induced neuromuscular blockade (NMB). In patients with compromised kidney function, most drugs show alteration of their pharmacokinetic profile with reduced clea...

  • Article
  • Open Access
7 Citations
4,018 Views
14 Pages

Emphysema-Predominant COPD Had a Greater 5-Year Mortality and a Worse Annual Decline in Lung Function Than Airway Obstruction-Predominant COPD or Asthma at Initial Same Degree of Airflow Obstruction

  • Chang-Wei Lin,
  • Hung-Yu Huang,
  • Fu-Tsai Chung,
  • Chun-Yu Lo and ,
  • Yu-Chen Huang,
  • Ting-Wen Wang,
  • Lan-Yan Yang,
  • Yu-Bin Pan,
  • Kian Fan Chung and
  • Chun-Hua Wang
  • + 5 authors+ 0 author

17 November 2021

Background and Objectives: We studied whether the extent of exertional oxygen desaturation and emphysema could cause greater mortality in COPD and asthma independent of airflow obstruction. Materials and Methods: We performed a 5-year longitudinal ob...

(This article belongs to the Special Issue Current Management Challenges in Chronic Obstructive Pulmonary Disease (COPD))
  • Systematic Review
  • Open Access
24 Citations
6,612 Views
14 Pages

17 November 2021

Background and Objective: Breast mass lesions are common; however, determining the malignant potential of the lesion can be ambiguous. Recently, to evaluate breast mass lesions, vacuum-assisted excision (VAE) biopsy has been widely used for both diag...

  • Review
  • Open Access
15 Citations
5,641 Views
8 Pages

Complex Regional Pain Syndrome in Athletes: Scoping Review

  • Antimo Moretti,
  • Angela Palomba,
  • Marco Paoletta,
  • Sara Liguori and ,
  • Giuseppe Toro and
  • Giovanni Iolascon
  • + 1 author+ 0 author

17 November 2021

Background and Objectives: Complex regional pain syndrome (CRPS) is a chronic condition characterized by disproportionate regional pain, usually affecting distal limbs, that follows trauma or surgery. Athletes may develop CRPS because of exposure to...

(This article belongs to the Special Issue Challenges and Solutions for Musculoskeletal Disorders in Athletes)
  • Review
  • Open Access
56 Citations
5,367 Views
10 Pages

Function of Follicular Cytokines: Roles Played during Maturation, Development and Implantation of Embryo

  • Rafał Adamczak,
  • Natalia Ukleja-Sokołowska,
  • Kinga Lis and
  • Mariusz Dubiel

16 November 2021

A balance within the immune system is necessary for the proper development of ovarian follicles. Numerous cytokines were detected in follicular fluid, the role of which in reproductive physiology seems crucial. They influence the development and matu...

(This article belongs to the Section Hematology and Immunology)
  • Review
  • Open Access
13 Citations
3,840 Views
25 Pages

16 November 2021

Background and Objectives: Lung cancer is the second most common cancer in the world. Non-small-cell lung carcinoma (NSCLC) makes up 85% of all lung cancer cases and the majority of patients are diagnosed when the cancer is advanced. Over the years,...

  • Case Report
  • Open Access
7 Citations
3,197 Views
9 Pages

Prenatal Diagnosis and Outcome of Tracheal Agenesis as Part of Congenital High Airway Obstruction Syndrome. Case Presentation and Literature Review

  • Tiberiu Georgescu,
  • Viorica Radoi,
  • Micaela Radulescu,
  • Aurora Ilian and ,
  • Oana Daniela Toader,
  • Lucian G. Pop and
  • Nicolae Bacalbasa
  • + 2 authors+ 0 author

16 November 2021

Tracheal atresia is an extremely rare condition whereby a partial or total obstruction of the trachea is seen. It is almost always lethal, with just a handful of cases that ended with a good outcome. In this study we report on a 15-week male fetus, d...

  • Article
  • Open Access
6 Citations
7,331 Views
9 Pages

Morphological Study of Fossa Ovalis in Formalin-Fixed Human Hearts and Its Clinical Importance

  • Monica Adriana Vaida,
  • Caius Glad Streian,
  • Cristina Gug,
  • Nawwaf Sebastian Damen and ,
  • Adelina Maria Jianu,
  • Andreea Grigoriță and
  • Laura Grigoriță
  • + 2 authors+ 0 author

16 November 2021

Background and Objectives: Our study aimed to investigate the gross anatomy aspects of the fossa ovalis (FO) and the presence of some anatomical variation resulting from the incomplete fusion of septum primum and septum secundum, such as an atrial se...

(This article belongs to the Special Issue Topographic Anatomy of the Human Body)
  • Article
  • Open Access
7 Citations
2,999 Views
8 Pages

Effects of Female Reproductive Hormone Levels on Inadvertent Intraoperative Hypothermia during Laparoscopic Gynecologic Surgery: A Retrospective Study

  • Cheol Lee,
  • SeongNam Park,
  • ByoungRyun Kim,
  • Hyeonbin Yim and ,
  • Myeongjong Lee,
  • Juhwan Lee and
  • Hyungtae Kim
  • + 2 authors+ 0 author

16 November 2021

Background and Objectives: Female reproductive hormones may affect core body temperature. This study aimed to investigate the effects of female reproductive hormones on inadvertent intraoperative hypothermia in patients who underwent laparoscopic gyn...

(This article belongs to the Section Obstetrics and Gynecology)
  • Article
  • Open Access
4 Citations
3,370 Views
11 Pages

15 November 2021

Background and objective: There is a general clinical concern on the negative impact of obesity on surgical complications and functional outcomes. We hypothesized that the patients with morbid obesity are exceptionally prone to a significantly increa...

(This article belongs to the Section Sports Medicine and Sports Traumatology)
  • Case Report
  • Open Access
6 Citations
3,008 Views
9 Pages

Reconstruction of a Lower Polar Artery for Kidney Transplantation Using Donor Ovarian Vein: Case Report with Literature Review

  • Saulė Bikauskaitė,
  • Kamilė Počepavičiūtė,
  • Linas Velička,
  • Antanas Jankauskas and ,
  • Darius Trumbeckas and
  • Erika Šuopytė
  • + 1 author+ 0 author

15 November 2021

Background: In the case of complicated kidney transplantation, when the accessory artery is severed, the main task is to decide whether to restore renal blood flow and which method should be used. In this report, we present a case of kidney transplan...

  • Article
  • Open Access
9 Citations
3,784 Views
11 Pages

Correlations between PNPLA3 Gene Polymorphisms and NAFLD in Type 2 Diabetic Patients

  • Oana Irina Gavril,
  • Lidia Iuliana Arhire,
  • Radu Sebastian Gavril,
  • Madalina Ioana Zota and ,
  • Andreea Gherasim,
  • Otilia Nita,
  • Andrei Drugescu,
  • Andrei Catalin Oprescu,
  • Irina Mihaela Esanu and
  • Laura Mihalache
  • + 7 authors+ 2 authors

15 November 2021

Background and Objectives: Non-alcoholic fatty liver disease is a worldwide significant public health problem, particularly in patients with type 2 diabetes mellitus. Identifying possible risk factors for the disease is mandatory for a better underst...

  • Article
  • Open Access
13 Citations
3,445 Views
10 Pages

Comparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis

  • Ha-Jung Kim,
  • Priodarshi Roychoudhury,
  • Stuti Lohia,
  • Jin-Sun Kim and ,
  • Hyung-Tae Kim,
  • Young-Jin Ro and
  • Won-Uk Koh
  • + 2 authors+ 0 author

15 November 2021

Background and Objectives: Some of the postoperative complications following orthopaedic surgeries are associated with a systemic inflammatory response (SIR), which varies depending on the anaesthetic technique. We aimed to compare the effects of gen...

  • Article
  • Open Access
8 Citations
2,754 Views
6 Pages

The Incidence of Gastrointestinal Stromal Tumors in Obese Patients—A Large Single Center Experience

  • Natalia Dowgiałło-Gornowicz,
  • Klaudia Sztaba,
  • Paweł Lech,
  • Anna Botulińska and
  • Maciej Michalik

14 November 2021

Background and Objectives: Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms located mainly in the fundus (60–70%). The incidence of GIST is approximately 10 per million population per year in Europe, with a peak incidence at the...

  • Article
  • Open Access
11 Citations
5,106 Views
14 Pages

Effects of Mean Artery Pressure and Blood pH on Survival Rate of Patients with Acute Kidney Injury Combined with Acute Hypoxic Respiratory Failure: A Retrospective Study

  • Chi-Hua Ko,
  • Ying-Wei Lan,
  • Ying-Chou Chen,
  • Tien-Tsai Cheng and ,
  • Shan-Fu Yu,
  • Abdulkadir Cidem,
  • Yu-Hsien Liu,
  • Chia-Wen Kuo,
  • Chih-Ching Yen and
  • Chuan-Mu Chen
  • + 6 authors+ 1 author

14 November 2021

Background and Objectives: In the intensive care unit (ICU), renal failure and respiratory failure are two of the most common organ failures in patients with systemic inflammatory response syndrome (SIRS). These clinical symptoms usually result from...

(This article belongs to the Special Issue Diagnosis and Treatment of Pulmonary Hypertension)
  • Review
  • Open Access
13 Citations
4,818 Views
16 Pages

Delirium and Cognitive Impairment as Predisposing Factors of COVID-19 Infection in Neuropsychiatric Patients: A Narrative Review

  • Michele Fabrazzo,
  • Antonio Russo,
  • Alessio Camerlengo,
  • Claudia Tucci and ,
  • Mario Luciano,
  • Valeria De Santis,
  • Francesco Perris,
  • Francesco Catapano and
  • Nicola Coppola
  • + 4 authors+ 0 author

14 November 2021

SARS-CoV-2 neuroinvasive and neurotropic abilities may underlie delirium onset and neuropsychiatric outcomes. Only a limited number of studies have addressed the potential effect of SARS-CoV-2 infection on mental health so far. Most studies mainly re...

(This article belongs to the Section Psychiatry)
  • Case Report
  • Open Access
6 Citations
4,561 Views
9 Pages

Non-IgE Mediated Hypersensitivity to Food Products or Food Intolerance—Problems of Appropriate Diagnostics

  • Dorota Myszkowska,
  • Barbara Zapała,
  • Małgorzata Bulanda and
  • Ewa Czarnobilska

14 November 2021

The diagnosis of food intolerance is tricky due to the different etiologies of adverse reactions. There is also a lack of clear rules for interpreting alternative tests used to diagnose these problems. The analyses of IgG4 concentration in serum or c...

  • Article
  • Open Access
12 Citations
5,757 Views
13 Pages

14 November 2021

Background and Objectives: We aimed to assess the diagnostic value of various immunohistochemical (IHC) markers and panels for differentiation among benign follicular nodules (BFNs), noninvasive follicular thyroid neoplasms with papillary-like nuclea...

  • Review
  • Open Access
15 Citations
11,788 Views
11 Pages

Contact Allergy Induced by Mango (Mangifera indica): A Relevant Topic?

  • Elena Camelia Berghea,
  • Mihai Craiu,
  • Selda Ali,
  • Sabina Loredana Corcea and
  • Roxana Silvia Bumbacea

13 November 2021

Introduction: The most common clinical manifestation of mango allergy is contact dermatitis, which can be localized or systemic. The sensitising substances that have long been suspected are alk(en)yl catechols and/or alk(en)yl resorcinols. Methods: W...

(This article belongs to the Special Issue Chronic Inflammatory Skin Diseases: Current Treatment and Future)
  • Case Report
  • Open Access
3 Citations
3,790 Views
7 Pages

13 November 2021

Ebstein anomaly is a rare congenital heart disease characterized by a varying degree of anatomical and functional abnormalities of tricuspid valve and right ventricle. It often coexists with other congenital cardiac malformations. Up to 79–89% of pat...

(This article belongs to the Section Cardiology)
  • Case Report
  • Open Access
4 Citations
3,027 Views
9 Pages

A Promising Role of TGF-β Pathway in Response to Regorafenib in Metastatic Colorectal Cancer: A Case Report

  • Simona De Summa,
  • Katia Danza,
  • Brunella Pilato,
  • Giuseppina Matera and ,
  • Rossella Fasano,
  • Angela Calabrese,
  • Rosanna Lacalamita,
  • Nicola Silvestris,
  • Stefania Tommasi and
  • Oronzo Brunetti
  • + 6 authors+ 1 author

13 November 2021

Colorectal cancer (CRC) is one of the most common cancer types around the world. The prognosis of patients with advanced diseases is still poor in spite of currently available therapeutic options. Regorafenib is an oral tyrosine kinase inhibitor (TKI...

(This article belongs to the Special Issue Therapeutic Landscapes in Colorectal Carcinoma)
  • Article
  • Open Access
9 Citations
3,062 Views
9 Pages

Syncope Time Frames for Adverse Events after Emergency Department Presentation: An Individual Patient Data Meta-Analysis

  • Ludovico Furlan,
  • Lucia Trombetta,
  • Giovanni Casazza,
  • Franca Dipaola and ,
  • Raffaello Furlan,
  • Chiara Marta,
  • Filippo Numeroso,
  • Jordi Pérez-Rodon,
  • James V. Quinn and
  • Monica Solbiati
  • + 12 authors+ 7 authors

12 November 2021

Background and Objectives: Knowledge of the incidence and time frames of the adverse events of patients presenting syncope at the ED is essential for developing effective management strategies. The aim of the present study was to perform a meta-analy...

(This article belongs to the Special Issue Syncope in the Emergency Department)
  • Article
  • Open Access
10 Citations
4,199 Views
9 Pages

Percutaneous Endoscopic Gastrostomy Tubes Can Be Considered Safe in Children: A Single-Center 11-Year Retrospective Analysis

  • Antonia Jeličić Kadić,
  • Tea Radošević,
  • Vanda Žitko,
  • Ranka Despot and ,
  • Zenon Pogorelić,
  • Carlos Martin Llorente Muñoz,
  • Edita Runjić,
  • Tanja Kovačević,
  • Tatjana Ćatipović Ardalić and
  • Joško Markić
  • + 6 authors+ 1 author

12 November 2021

Background and Objectives: When the human body is disabled to naturally ingest food through the mouth, enteral or parenteral nutritional support should be started. Percutaneous gastrostomy (PEG) is a flexible feeding tube that is inserted into the st...

(This article belongs to the Section Pediatrics)
  • Systematic Review
  • Open Access
39 Citations
12,935 Views
18 Pages

Management of Pulp Canal Obliteration—Systematic Review of Case Reports

  • Alexandra Vinagre,
  • Catarina Castanheira,
  • Ana Messias,
  • Paulo J. Palma and
  • João C. Ramos

12 November 2021

Background and Objectives: This systematic review aimed to assess the literature focusing on the clinical management of traumatized teeth with Pulp Canal Obliteration (PCO) and propose an updated clinical decision-making algorithm. The present review...

(This article belongs to the Special Issue Outcome of Minimally Invasive Techniques in Dentistry)
  • Case Report
  • Open Access
3 Citations
3,361 Views
4 Pages

Rare Orbital Metastasis Originating from Ampullary Adenocarcinoma

  • Yung-En Tsai,
  • Ke-Hung Chien,
  • Yao-Feng Li and
  • Shiue-Wei Lai

12 November 2021

Background: Orbital metastasis from ampullary carcinoma is rare, with no previously reported cases. Case presentation: We report the case of a 60-year-old man who complained of a right-sided headache, blurred vision, progressive proptosis, ptosis, an...

(This article belongs to the Section Ophthalmology)

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Medicina - ISSN 1648-9144