Special Issue "Recent Advances in Periodontics and Dental Implantology"

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Dentistry".

Deadline for manuscript submissions: 31 December 2022.

Special Issue Editor

Prof. Dr. Jun-Beom Park
E-Mail Website
Guest Editor
Department of Periodontics, College of Medicine, The Catholic University of Korea, Seoul, Korea
Interests: bone; bone biology; tissue engineering; stem cells; instrumentation; enzyme kinetics; bone regeneration; dental implants; biomaterials; oral health
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

With the advancement of technology, great progress has been made in the periodontology field. The prevalence of periodontal disease is relatively high and has been reported from 20­–45% or higher. Various treatments and biomaterials have been applied to increase the effectiveness of periodontal treatment. The long-term effects of periodontal treatment have been published. Despite advances in periodontal treatment, tooth extraction and further implant placement are being made. A protocol to increase the success rate of implants has been proposed. Various methods have been proposed that can be used in areas where the placement of dental implants is difficult. Stem cells and growth factors have been used as various biomaterials.

This scope of this Special Issue will serve as a forum for papers addressing the following concepts:

  • Understanding and mechanisms of periodontal disease;
  • Treatment of periodontal disease;
  • Short- and long-term effects of periodontal treatment;
  • Various soft and hard tissue regeneration methods;
  • Clinical outcome of dental implants;
  • Enhancement of efficacy with application of growth factors;
  • Cell therapy in periodontal and implant treatment.

Prof. Dr. Jun-Beom Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • periodontitis
  • inflammation
  • epidemiology
  • oral health
  • bone regeneration
  • bone biology
  • tissue engineering
  • dental implants
  • biomaterials
  • stem cells

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


Vitamin D Enhanced the Osteogenic Differentiation of Cell Spheroids Composed of Bone Marrow Stem Cells
Medicina 2021, 57(11), 1271; https://doi.org/10.3390/medicina57111271 - 19 Nov 2021
Viewed by 371
Background and Objectives: Vitamin D is a bone modulator widely used in regenerative medicine. This study aimed to analyze the effects of vitamin D on the osteogenic differentiation and mineralization of human mesenchymal stem cells. Materials and Methods: Spheroids were fabricated using human [...] Read more.
Background and Objectives: Vitamin D is a bone modulator widely used in regenerative medicine. This study aimed to analyze the effects of vitamin D on the osteogenic differentiation and mineralization of human mesenchymal stem cells. Materials and Methods: Spheroids were fabricated using human bone marrow-derived stem cells, and were cultured in the presence of vitamin D at concentrations of 0, 0.1, 1, 10, and 100 nM. Stem cell spheroids were fabricated and the morphological evaluation was conducted on days 1, 3, 7 and 14. Determination of qualitative cellular viability was performed with Live/Dead Kit assay on days 1 and 7. Quantitative cellular viability was evaluated with Cell Counting Kit-8 on days 1, 3, 7, and 14. To analyze the osteogenic differentiation of cell spheroids, alkaline phosphatase activity assays were performed with commercially available kit on days 7 and 14. Real-time polymerase chain reaction was used to determine the expression levels of RUNX2, BSP, OCN, and COL1A1 on days 7 and 14. Results: The stem cells produced well-formed spheroids, and addition of vitamin D did not result in any noticeable changes in the shape. The addition of vitamin D did not significantly change the diameter of the spheroids at 0, 0.1, 1, 10, or 100 nM concentrations. Quantitative cell viability results from days 1, 3, 7 and 14 showed no significant difference between groups (p > 0.05). There was significantly higher alkaline phosphatase activity in the 0.1 nM group when compared with the control group on day 14 (p < 0.05). Real-time polymerase chain reaction results demonstrated that the mRNA expression levels of RUNX2, OCN, and COL1A1 were significantly increased when vitamin D was added to the culture. Conclusions: Based on these findings, we concluded that vitamin D could be applied to the increased osteogenicity of stem cell spheroids. Full article
(This article belongs to the Special Issue Recent Advances in Periodontics and Dental Implantology)
Show Figures

Figure 1

Back to TopTop