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Current Issues in Molecular Biology, Volume 47, Issue 6

June 2025 - 93 articles

Cover Story: In this review, we examine the complex mechanisms underlying neuroinflammatory responses, with a focus on the interactions between glial cells and neurons. The dualistic role of neuroinflammation is further investigated, highlighting its ability to promote neuroprotection in acute phases while also contributing to neuronal injury and degeneration during chronic activation. In this review, we also consider innovative therapeutic approaches designed to target neuroinflammatory processes. A thorough understanding of the regulatory balance within neuroinflammatory networks is essential for the development of effective treatments for several neurological pathologies. Lastly, we provide an integrative summary of current evidence and highlight emerging directions in neuroinflammation research. View this paper
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Articles (93)

  • Review
  • Open Access
2 Citations
3,813 Views
19 Pages

Natural Bioactive Compounds in Sheep Milk: Potential Biomedical Applications

  • Zuzanna Flis,
  • Edyta Molik,
  • Anna Ptak and
  • Piotr Szatkowski

Sheep milk is a rich source of bioactive compounds with significant potential in functional foods and biomedical applications. It contains high levels of proteins, peptides, and fatty acids with numerous health-promoting properties for the human body...

  • Review
  • Open Access
2,412 Views
19 Pages

Targeting the cell cycle has become a focus of cancer research bearing impressive results with the introduction of CDK4/6 inhibitors in the treatment of ER-positive/HER2-negative breast cancers. However, no definitive benefit in other cancers has bee...

  • Article
  • Open Access
956 Views
13 Pages

Studies on populations exposed to inorganic arsenic (iAs) have shown an association with the development of chronic kidney disease (CKD) and renal cell carcinoma (RCC). However, there are few studies addressing how acute exposure of the human kidney...

  • Article
  • Open Access
1,413 Views
13 Pages

Miyako Bidens pilosa Extract Ameliorates Allodynia and Suppresses Spinal Microglial Activation in Mice with Partial Sciatic Nerve Ligation

  • Ai Takahashi,
  • Hiroko Miyagishi,
  • Komugi Tsuruta,
  • Hiroshi Nango,
  • Dai Hirose,
  • Yuri Aono,
  • Minoru Tanigawa,
  • Katsushi Nishimura,
  • Minoru Saito and
  • Takayuki Kawato
  • + 2 authors

Neuropathic pain, characterized by chronic allodynia, remains difficult to manage with current pharmacotherapies. Microglial activation plays a pivotal role in the development and maintenance of neuropathic pain and represents a promising therapeutic...

  • Review
  • Open Access
3 Citations
2,963 Views
21 Pages

Early Molecular Diagnosis and Comprehensive Treatment of Oral Cancer

  • Po-Chih Hsu,
  • Jen-Hsuan Huang,
  • Chung-Che Tsai,
  • Ya-Hsuan Lin and
  • Chan-Yen Kuo

Oral squamous cell carcinoma (OSCC), a major subtype of head and neck squamous cell carcinoma (HNSCC), is a significant global health burden owing to its late-stage diagnosis and poor prognosis. Recent advancements in molecular biology, genomics, and...

  • Article
  • Open Access
1 Citations
1,331 Views
18 Pages

Investigating the Effects of ONC206 Alone and in Combination with Cisplatin on Ovarian Cancer Cell Models

  • Sara Mikhael,
  • Rona Fayyad,
  • Leen Abi Harfouch,
  • Varun Vijay Prabhu,
  • Hisham F. Bahmad,
  • Wassim Abou-Kheir and
  • Georges Daoud

Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide, with high rates of disease relapse posing a significant therapeutic challenge. Consequently, there is an urgent need to develop novel treatments for OC. This study aims to evalu...

  • Article
  • Open Access
2 Citations
1,654 Views
19 Pages

Lipid-Lowering Potential of Almond Hulls (Quercetin, Baicalein, and Kaempferol): Insights from Network Pharmacology and Molecular Dynamics

  • Qiming Miao,
  • Lu Sun,
  • Jiayuan Wu,
  • Xinyue Zhu,
  • Juer Liu,
  • Roger Ruan,
  • Guangwei Huang,
  • Shengquan Mi and
  • Yanling Cheng

The advancement of modern lifestyles has precipitated excessive consumption of energy-dense foods, driving the escalating global burden of lipid metabolism dysregulation-related pathologies—including obesity, type 2 diabetes mellitus (T2DM), no...

  • Article
  • Open Access
1 Citations
962 Views
20 Pages

Soil salinization hinders plant growth and agricultural production, so breeding salt-tolerant crops is an economical way to exploit saline–alkali soils. However, the specific metabolites and associated pathways involved in salt tolerance of the...

  • Article
  • Open Access
878 Views
10 Pages

Tarantulas represent a highly diverse taxonomic group and play a crucial role in ecosystems. To gain a deeper understanding of the evolutionary relationships within the family Theraphosidae, in this study, we characterized the mitochondrial genome (m...

  • Review
  • Open Access
2 Citations
2,553 Views
34 Pages

The Application of Microsatellite Markers as Molecular Tools for Studying Genomic Variability in Vertebrate Populations

  • Roman O. Kulibaba,
  • Kornsorn Srikulnath,
  • Worapong Singchat,
  • Yuriy V. Liashenko,
  • Darren K. Griffin and
  • Michael N. Romanov

Vertebrate molecular genetic research methods typically employ single genetic loci (monolocus markers) and those involving a variable number of loci (multilocus markers). The former often employ microsatellites that ensure accuracy in establishing in...

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Curr. Issues Mol. Biol. - ISSN 1467-3045